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Ondansetron attenuates the decrease in blood pressure due to spinal anesthesia in the elderly: a double blind, placebo-controlled study.
Minerva Anestesiol 2015; 81(6):598-607MA

Abstract

BACKGROUND

Ondansetron was effectively used to prevent spinal anesthesia-induced hypotension in the general population and women anesthetised for cesarean section. The aim of this study was to test the hypothesis that blocking type 3 serotonin receptors with intravenous ondansetron administration reduces hypotension and bradycardia induced by spinal anesthesia in elderly patients.

METHODS

Fifty-three patients participated in the study with 26 in the ondansetron group (received 8 mg intravenous ondansetron) and 27 in the placebo group (received 0.9% NaCl solution). The heart rate and arterial blood pressure were measured every 5 minutes after spinal anaesthesia, which was performed with 2.5 to 3 mL of 0.5% hyperbaric bupivacaine solution.

RESULTS

Decreases in both the heart rate and mean systolic, as well as diastolic, arterial pressure compared to the baseline values were noted in both groups. The minimum diastolic and mean blood pressure values obtained over a 20-minute observation period were significantly higher in the ondansetron group. There were no significant differences in the systolic blood pressure and heart rate values between the groups.

CONCLUSION

Administration of intravenous ondansetron prior to spinal anesthesia in geriatric patients attenuates the drop in the diastolic and mean arterial pressure without substantially affecting the systolic blood pressure.

Authors+Show Affiliations

Department of Anesthesiology and Intensive Therapy, Medical University of Gdańsk, Gdańsk, Poland - r.owczuk@gumed.edu.pl.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25220555

Citation

Owczuk, R, et al. "Ondansetron Attenuates the Decrease in Blood Pressure Due to Spinal Anesthesia in the Elderly: a Double Blind, Placebo-controlled Study." Minerva Anestesiologica, vol. 81, no. 6, 2015, pp. 598-607.
Owczuk R, Wenski W, Twardowski P, et al. Ondansetron attenuates the decrease in blood pressure due to spinal anesthesia in the elderly: a double blind, placebo-controlled study. Minerva Anestesiol. 2015;81(6):598-607.
Owczuk, R., Wenski, W., Twardowski, P., Dylczyk-Sommer, A., Sawicka, W., Wujtewicz, M. A., ... Wujtewicz, M. (2015). Ondansetron attenuates the decrease in blood pressure due to spinal anesthesia in the elderly: a double blind, placebo-controlled study. Minerva Anestesiologica, 81(6), pp. 598-607.
Owczuk R, et al. Ondansetron Attenuates the Decrease in Blood Pressure Due to Spinal Anesthesia in the Elderly: a Double Blind, Placebo-controlled Study. Minerva Anestesiol. 2015;81(6):598-607. PubMed PMID: 25220555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ondansetron attenuates the decrease in blood pressure due to spinal anesthesia in the elderly: a double blind, placebo-controlled study. AU - Owczuk,R, AU - Wenski,W, AU - Twardowski,P, AU - Dylczyk-Sommer,A, AU - Sawicka,W, AU - Wujtewicz,M A, AU - Marciniak,A, AU - Polak-Krzemińska,A, AU - Jasiński,T, AU - Wujtewicz,M, PY - 2014/9/16/entrez PY - 2014/9/16/pubmed PY - 2016/12/15/medline SP - 598 EP - 607 JF - Minerva anestesiologica JO - Minerva Anestesiol VL - 81 IS - 6 N2 - BACKGROUND: Ondansetron was effectively used to prevent spinal anesthesia-induced hypotension in the general population and women anesthetised for cesarean section. The aim of this study was to test the hypothesis that blocking type 3 serotonin receptors with intravenous ondansetron administration reduces hypotension and bradycardia induced by spinal anesthesia in elderly patients. METHODS: Fifty-three patients participated in the study with 26 in the ondansetron group (received 8 mg intravenous ondansetron) and 27 in the placebo group (received 0.9% NaCl solution). The heart rate and arterial blood pressure were measured every 5 minutes after spinal anaesthesia, which was performed with 2.5 to 3 mL of 0.5% hyperbaric bupivacaine solution. RESULTS: Decreases in both the heart rate and mean systolic, as well as diastolic, arterial pressure compared to the baseline values were noted in both groups. The minimum diastolic and mean blood pressure values obtained over a 20-minute observation period were significantly higher in the ondansetron group. There were no significant differences in the systolic blood pressure and heart rate values between the groups. CONCLUSION: Administration of intravenous ondansetron prior to spinal anesthesia in geriatric patients attenuates the drop in the diastolic and mean arterial pressure without substantially affecting the systolic blood pressure. SN - 1827-1596 UR - https://www.unboundmedicine.com/medline/citation/25220555/Ondansetron_attenuates_the_decrease_in_blood_pressure_due_to_spinal_anesthesia_in_the_elderly:_a_double_blind_placebo_controlled_study_ L2 - http://www.minervamedica.it/index2.t?show=R02Y2015N06A0598 DB - PRIME DP - Unbound Medicine ER -