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Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly.
Nutrients. 2014 Sep 12; 6(9):3624-40.N

Abstract

Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥ 60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly.

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Authors+Show Affiliations

Baierle M
Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre 90610000, RS, Brazil. mariliabaierle@yahoo.com.br.
Vencato PH
Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre 90610000, RS, Brazil. patriciavencato@gmail.com.
Oldenburg L
Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre 90610000, RS, Brazil. luoldenburg@yahoo.com.br.
Bordignon S
Institute of Psychology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90035003, RS, Brazil. su.suelen@gmail.com.
Zibetti M
Institute of Psychology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90035003, RS, Brazil. mugazibetti@gmail.com.
Trentini CM
Institute of Psychology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90035003, RS, Brazil. clarissatrentini@terra.com.br.
Duarte MM
Department of Health Sciences, Lutheran University of Brazil, Santa Maria 97020001, RS, Brazil. duartmm@hotmail.com.
Veit JC
Department of Alimentary Technology and Science, Federal University of Santa Maria (UFSM), Santa Maria 97105900, RS, Brazil. juliana_veit@hotmail.com.
Somacal S
Department of Alimentary Technology and Science, Federal University of Santa Maria (UFSM), Santa Maria 97105900, RS, Brazil. s_somacal@hotmail.com.
Emanuelli T
Department of Alimentary Technology and Science, Federal University of Santa Maria (UFSM), Santa Maria 97105900, RS, Brazil. tatiemanuelli@gmail.com.
Grune T
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Jena 07743, Germany. tilman.grune@uni-jena.de.
Breusing N
Department of Applied Nutritional Science and Dietetics, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart 70593, Germany. breusing@uni-hohenheim.de.
Garcia SC
Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre 90610000, RS, Brazil. solange.garcia@ufrgs.br.

MeSH

AgedAged, 80 and overAlzheimer DiseaseC-Reactive ProteinCardiovascular DiseasesCase-Control StudiesCognitionCognition DisordersDementiaDietDocosahexaenoic AcidsFatty Acids, Omega-3Fatty Acids, Omega-6Fatty Acids, UnsaturatedFemaleGeriatric AssessmentHomocysteineHumansLipidsMaleMemoryNutritional StatusRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25221976

Clinical Trial Links

Can Lifestyle Changes Reverse Early-Stage Alzheimer's Disease

Citation

Baierle, Marília, et al. "Fatty Acid Status and Its Relationship to Cognitive Decline and Homocysteine Levels in the Elderly." Nutrients, vol. 6, no. 9, 2014, pp. 3624-40.
Baierle M, Vencato PH, Oldenburg L, et al. Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly. Nutrients. 2014;6(9):3624-40.
Baierle, M., Vencato, P. H., Oldenburg, L., Bordignon, S., Zibetti, M., Trentini, C. M., Duarte, M. M., Veit, J. C., Somacal, S., Emanuelli, T., Grune, T., Breusing, N., & Garcia, S. C. (2014). Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly. Nutrients, 6(9), 3624-40. https://doi.org/10.3390/nu6093624
Baierle M, et al. Fatty Acid Status and Its Relationship to Cognitive Decline and Homocysteine Levels in the Elderly. Nutrients. 2014 Sep 12;6(9):3624-40. PubMed PMID: 25221976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly. AU - Baierle,Marília, AU - Vencato,Patrícia H, AU - Oldenburg,Luiza, AU - Bordignon,Suelen, AU - Zibetti,Murilo, AU - Trentini,Clarissa M, AU - Duarte,Marta M M F, AU - Veit,Juliana C, AU - Somacal,Sabrina, AU - Emanuelli,Tatiana, AU - Grune,Tilman, AU - Breusing,Nicolle, AU - Garcia,Solange C, Y1 - 2014/09/12/ PY - 2014/05/24/received PY - 2014/07/11/revised PY - 2014/08/28/accepted PY - 2014/9/16/entrez PY - 2014/9/16/pubmed PY - 2015/5/12/medline SP - 3624 EP - 40 JF - Nutrients JO - Nutrients VL - 6 IS - 9 N2 - Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥ 60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/25221976/Fatty_acid_status_and_its_relationship_to_cognitive_decline_and_homocysteine_levels_in_the_elderly_ DB - PRIME DP - Unbound Medicine ER -