Tags

Type your tag names separated by a space and hit enter

Dietary sodium restriction: a neglected therapeutic opportunity in chronic kidney disease.
Curr Opin Nephrol Hypertens. 2014 Nov; 23(6):533-40.CO

Abstract

PURPOSE OF REVIEW

Restriction of dietary sodium is recommended at a population level as well as for groups at high cardiovascular risk, and chronic kidney disease (CKD). This review addresses recent evidence for the protective effect of dietary sodium restriction in CKD patients specifically.

RECENT FINDINGS

Sodium intake in CKD populations is generally high, and often above population average. Recent data demonstrated that moderately lower sodium intake in CKD patients is associated with substantially better long-term outcome of renin-angiotensin-aldosterone system (RAAS)-blockade, in diabetic and nondiabetic CKD, related to better effects of RAAS-blockade on proteinuria, independent of blood pressure. This is in line with better short-term efficacy of RAAS-blockade during moderate sodium restriction in diabetic and nondiabetic CKD. This effect of sodium restriction is likely mediated by its effects on volume status. Sustainable sodium restriction can be achieved by approaches on the basis of behavioral sciences.

SUMMARY

Moderate restriction of dietary sodium can substantially improve the protective effects of RAAS-blockade in CKD, by specific renal effects apparent from proteinuria reduction. The latter precludes straightforward extrapolation of data from nonrenal populations to CKD. Concerns regarding the adverse effects of a very low sodium intake should not distract from the protective effects of moderate sodium restriction. Prospective studies should assess the efficacy and sustainability of different strategies to target high sodium intake in CKD, along with measures at population level.

VIDEO ABSTRACT

http://links.lww.com/CONH/A14.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25222815

Citation

Humalda, Jelmer K., and Gerjan Navis. "Dietary Sodium Restriction: a Neglected Therapeutic Opportunity in Chronic Kidney Disease." Current Opinion in Nephrology and Hypertension, vol. 23, no. 6, 2014, pp. 533-40.
Humalda JK, Navis G. Dietary sodium restriction: a neglected therapeutic opportunity in chronic kidney disease. Curr Opin Nephrol Hypertens. 2014;23(6):533-40.
Humalda, J. K., & Navis, G. (2014). Dietary sodium restriction: a neglected therapeutic opportunity in chronic kidney disease. Current Opinion in Nephrology and Hypertension, 23(6), 533-40. https://doi.org/10.1097/MNH.0000000000000073
Humalda JK, Navis G. Dietary Sodium Restriction: a Neglected Therapeutic Opportunity in Chronic Kidney Disease. Curr Opin Nephrol Hypertens. 2014;23(6):533-40. PubMed PMID: 25222815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary sodium restriction: a neglected therapeutic opportunity in chronic kidney disease. AU - Humalda,Jelmer K, AU - Navis,Gerjan, PY - 2014/9/16/entrez PY - 2014/9/16/pubmed PY - 2015/6/11/medline SP - 533 EP - 40 JF - Current opinion in nephrology and hypertension JO - Curr Opin Nephrol Hypertens VL - 23 IS - 6 N2 - PURPOSE OF REVIEW: Restriction of dietary sodium is recommended at a population level as well as for groups at high cardiovascular risk, and chronic kidney disease (CKD). This review addresses recent evidence for the protective effect of dietary sodium restriction in CKD patients specifically. RECENT FINDINGS: Sodium intake in CKD populations is generally high, and often above population average. Recent data demonstrated that moderately lower sodium intake in CKD patients is associated with substantially better long-term outcome of renin-angiotensin-aldosterone system (RAAS)-blockade, in diabetic and nondiabetic CKD, related to better effects of RAAS-blockade on proteinuria, independent of blood pressure. This is in line with better short-term efficacy of RAAS-blockade during moderate sodium restriction in diabetic and nondiabetic CKD. This effect of sodium restriction is likely mediated by its effects on volume status. Sustainable sodium restriction can be achieved by approaches on the basis of behavioral sciences. SUMMARY: Moderate restriction of dietary sodium can substantially improve the protective effects of RAAS-blockade in CKD, by specific renal effects apparent from proteinuria reduction. The latter precludes straightforward extrapolation of data from nonrenal populations to CKD. Concerns regarding the adverse effects of a very low sodium intake should not distract from the protective effects of moderate sodium restriction. Prospective studies should assess the efficacy and sustainability of different strategies to target high sodium intake in CKD, along with measures at population level. VIDEO ABSTRACT: http://links.lww.com/CONH/A14. SN - 1473-6543 UR - https://www.unboundmedicine.com/medline/citation/25222815/Dietary_sodium_restriction:_a_neglected_therapeutic_opportunity_in_chronic_kidney_disease_ L2 - https://doi.org/10.1097/MNH.0000000000000073 DB - PRIME DP - Unbound Medicine ER -