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[Effect of kuntai capsule on the number of retrieved oocytes, high-quality oocytes and embryos in in vitro fertilization of poor ovarian response patients].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Aug; 34(8):917-21.ZZ

Abstract

OBJECTIVE

To observe the effect of Kuntai Capsule (KC) on the number of retrieved oocytes, the quality of high-quality oocytes and embryos in in vitro fertilization of poor ovarian response (POR) patients.

METHODS

Totally 70 POR patients preparing for in vitro fertilization-embryo transfer (IVF-ET) were randomly assigned to the observation group and the control group, 35 cases in each group. KC was administered to patients in the observation group in the preparation cycle (i.e., three menstrual cycles before IVF-ET) and during the superovulation process. Those in the control group took placebo during this period. Before and after medication the improvement of Shen yin deficiency syndrome (SYDS) was observed in the two groups. The basal follicle-stimulating hormone (bFSH), luteinizing hormone (LH), estradiol (E2), anti-Mullerian hormone (AMH), the ratio of FSH to LH, and antral follicle count (AFC) were observed. Besides, the E2 level of a single ovum on the day of HCG injection, the number of retrieved oocytes, the high-quality oocyte rate, and the high-quality embryos were observed.

RESULTS

Compared with the control group, the SYDS, decreased bFSH and LH levels, increased ACF numbers, the E2 level of a single ovum on the day of HCG injection, the number of retrieved oocytes, high-quality oocytes, and high-quality embryos were superior in the observation group (P < 0.05). There was no statistical difference in the decreased FSH/LH level (P > 0.05). E2 and AMH increased after medication of KC in the observation group, while they decreased after administration of placebos in the control group. There was statistical difference in the post-pre treatment difference of E2 and AMH between the two groups (P < 0.05).

CONCLUSION

KC could increase the number of retrieved oocytes, and elevate the quality of occytes and embryos in the IVF-ET.

Authors

Lian F
No affiliation info available
Jiang XY
No affiliation info available

MeSH

AdultDrugs, Chinese HerbalEmbryo TransferFemaleFertilization in VitroHumansOocyte RetrievalOocytesPregnancy

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

25223172

Citation

Lian, Fang, and Xiao-Yuan Jiang. "[Effect of Kuntai Capsule On the Number of Retrieved Oocytes, High-quality Oocytes and Embryos in in Vitro Fertilization of Poor Ovarian Response Patients]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 34, no. 8, 2014, pp. 917-21.
Lian F, Jiang XY. [Effect of kuntai capsule on the number of retrieved oocytes, high-quality oocytes and embryos in in vitro fertilization of poor ovarian response patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34(8):917-21.
Lian, F., & Jiang, X. Y. (2014). [Effect of kuntai capsule on the number of retrieved oocytes, high-quality oocytes and embryos in in vitro fertilization of poor ovarian response patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 34(8), 917-21.
Lian F, Jiang XY. [Effect of Kuntai Capsule On the Number of Retrieved Oocytes, High-quality Oocytes and Embryos in in Vitro Fertilization of Poor Ovarian Response Patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34(8):917-21. PubMed PMID: 25223172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of kuntai capsule on the number of retrieved oocytes, high-quality oocytes and embryos in in vitro fertilization of poor ovarian response patients]. AU - Lian,Fang, AU - Jiang,Xiao-Yuan, PY - 2014/9/17/entrez PY - 2014/9/17/pubmed PY - 2015/1/16/medline SP - 917 EP - 21 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 34 IS - 8 N2 - OBJECTIVE: To observe the effect of Kuntai Capsule (KC) on the number of retrieved oocytes, the quality of high-quality oocytes and embryos in in vitro fertilization of poor ovarian response (POR) patients. METHODS: Totally 70 POR patients preparing for in vitro fertilization-embryo transfer (IVF-ET) were randomly assigned to the observation group and the control group, 35 cases in each group. KC was administered to patients in the observation group in the preparation cycle (i.e., three menstrual cycles before IVF-ET) and during the superovulation process. Those in the control group took placebo during this period. Before and after medication the improvement of Shen yin deficiency syndrome (SYDS) was observed in the two groups. The basal follicle-stimulating hormone (bFSH), luteinizing hormone (LH), estradiol (E2), anti-Mullerian hormone (AMH), the ratio of FSH to LH, and antral follicle count (AFC) were observed. Besides, the E2 level of a single ovum on the day of HCG injection, the number of retrieved oocytes, the high-quality oocyte rate, and the high-quality embryos were observed. RESULTS: Compared with the control group, the SYDS, decreased bFSH and LH levels, increased ACF numbers, the E2 level of a single ovum on the day of HCG injection, the number of retrieved oocytes, high-quality oocytes, and high-quality embryos were superior in the observation group (P < 0.05). There was no statistical difference in the decreased FSH/LH level (P > 0.05). E2 and AMH increased after medication of KC in the observation group, while they decreased after administration of placebos in the control group. There was statistical difference in the post-pre treatment difference of E2 and AMH between the two groups (P < 0.05). CONCLUSION: KC could increase the number of retrieved oocytes, and elevate the quality of occytes and embryos in the IVF-ET. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/25223172/[Effect_of_kuntai_capsule_on_the_number_of_retrieved_oocytes_high_quality_oocytes_and_embryos_in_in_vitro_fertilization_of_poor_ovarian_response_patients]_ DB - PRIME DP - Unbound Medicine ER -