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The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients.
Pancreatology 2014 Nov-Dec; 14(6):490-6P

Abstract

OBJECTIVES

A nationwide survey was conducted to clarify the epidemiological features of patients with chronic pancreatitis (CP) in Japan.

METHODS

In the first survey, both the prevalence and the incidence of CP in 2011 were estimated. In the second survey, the clinicoepidemiological features of the patients were clarified by mailed questionnaires. Patients were diagnosed by the Japanese diagnostic criteria for chronic pancreatitis 2009.

RESULTS

The estimated annual prevalence and incidence of CP in 2011 were 52.4/100,000 and 14.0/100,000, respectively. The sex ratio (male/female) of patients was 4.6, with a mean age of 62.3 years. Alcoholic (67.5%) was the most common and idiopathic (20.0%) was the second most common cause of CP. Comorbidity with diabetes mellitus (DM) and pancreatic calcifications (PC) occurred more frequent in ever smokers independently of their drinking status. Among patients without drinking habit, the incidences of DM and PC were significantly higher in ever smokers than in never smokers. The multiple logistic regression analysis revealed smoking was an independent factor of DM and PC in CP patients: DM, Odds ratio (OR) 1.644, 95% confidence interval (CI) 1.202 to 2.247 (P = 0.002): PC, OR 2.010, 95% CI 1.458 to 2.773 (P < 0.001). On the other hand, smoking was not identified as an independent factor for the appearance of abdominal pain by this analysis.

CONCLUSION

The prevalence of Japanese patients with CP has been increasing. Smoking was identified as an independent factor related to DM and PC in Japanese CP patients.

Authors+Show Affiliations

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. Electronic address: tshimosegawa@int3.med.tohoku.ac.jp.Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.Department of Gastroenterology, Sendai Medical Center, Sendai, Miyagi, Japan.Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.Molecular Epidemiology, Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25224249

Citation

Hirota, Morihisa, et al. "The Seventh Nationwide Epidemiological Survey for Chronic Pancreatitis in Japan: Clinical Significance of Smoking Habit in Japanese Patients." Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], vol. 14, no. 6, 2014, pp. 490-6.
Hirota M, Shimosegawa T, Masamune A, et al. The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients. Pancreatology. 2014;14(6):490-6.
Hirota, M., Shimosegawa, T., Masamune, A., Kikuta, K., Kume, K., Hamada, S., ... Kuriyama, S. (2014). The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients. Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], 14(6), pp. 490-6. doi:10.1016/j.pan.2014.08.008.
Hirota M, et al. The Seventh Nationwide Epidemiological Survey for Chronic Pancreatitis in Japan: Clinical Significance of Smoking Habit in Japanese Patients. Pancreatology. 2014;14(6):490-6. PubMed PMID: 25224249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients. AU - Hirota,Morihisa, AU - Shimosegawa,Tooru, AU - Masamune,Atsushi, AU - Kikuta,Kazuhiro, AU - Kume,Kiyoshi, AU - Hamada,Shin, AU - Kanno,Atsushi, AU - Kimura,Kenji, AU - Tsuji,Ichiro, AU - Kuriyama,Shinichi, AU - ,, Y1 - 2014/09/03/ PY - 2014/06/11/received PY - 2014/08/23/revised PY - 2014/08/26/accepted PY - 2014/9/17/entrez PY - 2014/9/17/pubmed PY - 2015/8/8/medline KW - Alcoholic KW - Chronic pancreatitis KW - Early stage KW - Epidemiology KW - Prevalence KW - Smoking SP - 490 EP - 6 JF - Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] JO - Pancreatology VL - 14 IS - 6 N2 - OBJECTIVES: A nationwide survey was conducted to clarify the epidemiological features of patients with chronic pancreatitis (CP) in Japan. METHODS: In the first survey, both the prevalence and the incidence of CP in 2011 were estimated. In the second survey, the clinicoepidemiological features of the patients were clarified by mailed questionnaires. Patients were diagnosed by the Japanese diagnostic criteria for chronic pancreatitis 2009. RESULTS: The estimated annual prevalence and incidence of CP in 2011 were 52.4/100,000 and 14.0/100,000, respectively. The sex ratio (male/female) of patients was 4.6, with a mean age of 62.3 years. Alcoholic (67.5%) was the most common and idiopathic (20.0%) was the second most common cause of CP. Comorbidity with diabetes mellitus (DM) and pancreatic calcifications (PC) occurred more frequent in ever smokers independently of their drinking status. Among patients without drinking habit, the incidences of DM and PC were significantly higher in ever smokers than in never smokers. The multiple logistic regression analysis revealed smoking was an independent factor of DM and PC in CP patients: DM, Odds ratio (OR) 1.644, 95% confidence interval (CI) 1.202 to 2.247 (P = 0.002): PC, OR 2.010, 95% CI 1.458 to 2.773 (P < 0.001). On the other hand, smoking was not identified as an independent factor for the appearance of abdominal pain by this analysis. CONCLUSION: The prevalence of Japanese patients with CP has been increasing. Smoking was identified as an independent factor related to DM and PC in Japanese CP patients. SN - 1424-3911 UR - https://www.unboundmedicine.com/medline/citation/25224249/The_seventh_nationwide_epidemiological_survey_for_chronic_pancreatitis_in_Japan:_clinical_significance_of_smoking_habit_in_Japanese_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1424-3903(14)00970-3 DB - PRIME DP - Unbound Medicine ER -