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The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in Southwest of Iran.
Reprod Biol Endocrinol. 2014 Sep 16; 12:89.RB

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is a common endocrinopathy, associated with metabolic abnormalities. Metabolic features of various phenotypes of this syndrome are still debatable. The aim of present study hence was to evaluate the metabolic and hormonal features of PCOS phenotypes in comparison to a group of healthy control.

METHODS

A total of 646 reproductive-aged women were randomly selected using the stratified, multistage probability cluster sampling method. The subjects were divided into five phenotypes: A (oligo/anovulation + hyperandrogenism + polycystic ovaries), B (oligo/anovulation + hyperandrogenism), C (hyperandrogenism + polycystic ovaries) and D (oligo/anovulation + polycystic ovaries). Hormonal and metabolic profiles and the prevalence of metabolic syndrome among these groups were compared using ANCOVA adjusted for age and body mass index.

RESULTS

Among women with PCOS (n = 85), those of groups A and C had higher serum levels of insulin and homeostatic model assessment for insulin resistance (HOMA-IR), compared to PCOS women of group D. Serum concentrations of cholesterol, low density lipoprotein, triglycerides and glucose in group A were higher than in other phenotypes, whereas the metabolic syndrome was more prevalent among group B.

CONCLUSIONS

Women who had all three components of the syndrome showed the highest level of metabolic disturbances indicating that metabolic screening of the severest phenotype of PCOS may be necessary.

Links

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Authors+Show Affiliations

Tehrani FR
No affiliation info available
Rashidi H
Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. hrashidi@ajums.ac.ir.
Khomami MB
No affiliation info available
Tohidi M
No affiliation info available
Azizi F
No affiliation info available

MeSH

AdultAnovulationCluster AnalysisFemaleHumansHyperandrogenismInsulin ResistanceIranMetabolic SyndromeOvaryPolycystic Ovary SyndromePrevalenceSeverity of Illness IndexUltrasonographyYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25224635

Citation

Tehrani, Fahimeh Ramezani, et al. "The Prevalence of Metabolic Disorders in Various Phenotypes of Polycystic Ovary Syndrome: a Community Based Study in Southwest of Iran." Reproductive Biology and Endocrinology : RB&E, vol. 12, 2014, p. 89.
Tehrani FR, Rashidi H, Khomami MB, et al. The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in Southwest of Iran. Reprod Biol Endocrinol. 2014;12:89.
Tehrani, F. R., Rashidi, H., Khomami, M. B., Tohidi, M., & Azizi, F. (2014). The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in Southwest of Iran. Reproductive Biology and Endocrinology : RB&E, 12, 89. https://doi.org/10.1186/1477-7827-12-89
Tehrani FR, et al. The Prevalence of Metabolic Disorders in Various Phenotypes of Polycystic Ovary Syndrome: a Community Based Study in Southwest of Iran. Reprod Biol Endocrinol. 2014 Sep 16;12:89. PubMed PMID: 25224635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in Southwest of Iran. AU - Tehrani,Fahimeh Ramezani, AU - Rashidi,Homeira, AU - Khomami,Mahnaz Bahri, AU - Tohidi,Maryam, AU - Azizi,Fereidoun, Y1 - 2014/09/16/ PY - 2014/06/08/received PY - 2014/08/26/accepted PY - 2014/9/17/entrez PY - 2014/9/17/pubmed PY - 2015/3/31/medline SP - 89 EP - 89 JF - Reproductive biology and endocrinology : RB&E JO - Reprod Biol Endocrinol VL - 12 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrinopathy, associated with metabolic abnormalities. Metabolic features of various phenotypes of this syndrome are still debatable. The aim of present study hence was to evaluate the metabolic and hormonal features of PCOS phenotypes in comparison to a group of healthy control. METHODS: A total of 646 reproductive-aged women were randomly selected using the stratified, multistage probability cluster sampling method. The subjects were divided into five phenotypes: A (oligo/anovulation + hyperandrogenism + polycystic ovaries), B (oligo/anovulation + hyperandrogenism), C (hyperandrogenism + polycystic ovaries) and D (oligo/anovulation + polycystic ovaries). Hormonal and metabolic profiles and the prevalence of metabolic syndrome among these groups were compared using ANCOVA adjusted for age and body mass index. RESULTS: Among women with PCOS (n = 85), those of groups A and C had higher serum levels of insulin and homeostatic model assessment for insulin resistance (HOMA-IR), compared to PCOS women of group D. Serum concentrations of cholesterol, low density lipoprotein, triglycerides and glucose in group A were higher than in other phenotypes, whereas the metabolic syndrome was more prevalent among group B. CONCLUSIONS: Women who had all three components of the syndrome showed the highest level of metabolic disturbances indicating that metabolic screening of the severest phenotype of PCOS may be necessary. SN - 1477-7827 UR - https://www.unboundmedicine.com/medline/citation/25224635/The_prevalence_of_metabolic_disorders_in_various_phenotypes_of_polycystic_ovary_syndrome:_a_community_based_study_in_Southwest_of_Iran_ DB - PRIME DP - Unbound Medicine ER -