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The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia.
Vet Parasitol. 2014 Oct 15; 205(3-4):575-80.VP

Abstract

This study was performed to estimate the prevalence of patent Parascaris equorum infections and determine the efficacy of ivermectin, pyrantel and fenbendazole against P. equorum infection in foals on farms in southern Australia. Foals aged >3 months on five farms in the south-western slopes region of New South Wales were used. Faeces were collected from each foal and foals with a P. equorum faecal egg count (FEC) of >100 eggs per gram (EPG) were used to measure anthelmintic efficacy using the FEC reduction (FECR) test, after random allocation to a control group or an ivermectin, pyrantel embonate or fenbendazole treatment group. Treatment was administered on day 0 and faeces were collected on day 14 and a FEC was performed. For determination of anthelmintic efficacy, FECRs and lower 95% confidence intervals (LCL) were calculated using previously described methods, based on individual or group FECRs. P. equorum populations were considered susceptible when FECR was >90% and LCL >90%, suspected resistant when FECR was FECR was 80-90% and LCL <90% and resistant when FECR was <80% and LCL <90%. A Poisson distribution quality control method was applied to the data to remove suspected erroneous FECR results. Prevalence of patent P. equorum infection was 58.3% (147/252 foals) and 89 foals on 5 farms were included in the FECR study. Resistance of P. equorum to ≥ 1 anthelmintic was present on all five farms prior to and on four farms after application of the quality control method. Two farms had evidence of multiple drug resistance. Ivermectin was effective and ineffective on two and three farms, respectively. Fenbendazole was effective on two farms, equivocal on one farm and ineffective on one farm. Pyrantel embonate was effective on three farms and ineffective on one farm. These data indicate that anthelmintic-resistant P. equorum populations are present on farms in Australia and multiple drug resistance may occur on individual farms.

Authors+Show Affiliations

School of Animal & Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, New South Wales 2678, Australia.School of Animal & Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, New South Wales 2678, Australia.School of Animal & Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, New South Wales 2678, Australia.School of Animal & Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, New South Wales 2678, Australia.School of Animal & Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, New South Wales 2678, Australia.School of Animal & Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, New South Wales 2678, Australia. Electronic address: krhughes@csu.edu.au.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25224788

Citation

Armstrong, S K., et al. "The Efficacy of Ivermectin, Pyrantel and Fenbendazole Against Parascaris Equorum Infection in Foals On Farms in Australia." Veterinary Parasitology, vol. 205, no. 3-4, 2014, pp. 575-80.
Armstrong SK, Woodgate RG, Gough S, et al. The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia. Vet Parasitol. 2014;205(3-4):575-80.
Armstrong, S. K., Woodgate, R. G., Gough, S., Heller, J., Sangster, N. C., & Hughes, K. J. (2014). The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia. Veterinary Parasitology, 205(3-4), 575-80. https://doi.org/10.1016/j.vetpar.2014.08.028
Armstrong SK, et al. The Efficacy of Ivermectin, Pyrantel and Fenbendazole Against Parascaris Equorum Infection in Foals On Farms in Australia. Vet Parasitol. 2014 Oct 15;205(3-4):575-80. PubMed PMID: 25224788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia. AU - Armstrong,S K, AU - Woodgate,R G, AU - Gough,S, AU - Heller,J, AU - Sangster,N C, AU - Hughes,K J, Y1 - 2014/09/06/ PY - 2014/02/07/received PY - 2014/08/23/revised PY - 2014/08/28/accepted PY - 2014/9/17/entrez PY - 2014/9/17/pubmed PY - 2017/3/3/medline KW - Anthelmintic KW - Efficacy KW - Equine KW - Horse KW - Parascaris equorum KW - Resistance SP - 575 EP - 80 JF - Veterinary parasitology JO - Vet Parasitol VL - 205 IS - 3-4 N2 - This study was performed to estimate the prevalence of patent Parascaris equorum infections and determine the efficacy of ivermectin, pyrantel and fenbendazole against P. equorum infection in foals on farms in southern Australia. Foals aged >3 months on five farms in the south-western slopes region of New South Wales were used. Faeces were collected from each foal and foals with a P. equorum faecal egg count (FEC) of >100 eggs per gram (EPG) were used to measure anthelmintic efficacy using the FEC reduction (FECR) test, after random allocation to a control group or an ivermectin, pyrantel embonate or fenbendazole treatment group. Treatment was administered on day 0 and faeces were collected on day 14 and a FEC was performed. For determination of anthelmintic efficacy, FECRs and lower 95% confidence intervals (LCL) were calculated using previously described methods, based on individual or group FECRs. P. equorum populations were considered susceptible when FECR was >90% and LCL >90%, suspected resistant when FECR was FECR was 80-90% and LCL <90% and resistant when FECR was <80% and LCL <90%. A Poisson distribution quality control method was applied to the data to remove suspected erroneous FECR results. Prevalence of patent P. equorum infection was 58.3% (147/252 foals) and 89 foals on 5 farms were included in the FECR study. Resistance of P. equorum to ≥ 1 anthelmintic was present on all five farms prior to and on four farms after application of the quality control method. Two farms had evidence of multiple drug resistance. Ivermectin was effective and ineffective on two and three farms, respectively. Fenbendazole was effective on two farms, equivocal on one farm and ineffective on one farm. Pyrantel embonate was effective on three farms and ineffective on one farm. These data indicate that anthelmintic-resistant P. equorum populations are present on farms in Australia and multiple drug resistance may occur on individual farms. SN - 1873-2550 UR - https://www.unboundmedicine.com/medline/citation/25224788/The_efficacy_of_ivermectin_pyrantel_and_fenbendazole_against_Parascaris_equorum_infection_in_foals_on_farms_in_Australia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(14)00482-8 DB - PRIME DP - Unbound Medicine ER -