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Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China.
PLoS One. 2014; 9(9):e107181.Plos

Abstract

INTRODUCTION

Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology and outcome of severe sepsis and septic shock in mixed ICU in mainland China, as well as the independent predictors of mortality.

METHODS

We performed a 2-month prospective, observational cohort study in 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during the study period were screened and patients with severe sepsis or septic shock were included.

RESULTS

A total of 484 patients, 37.3 per 100 ICU admissions were diagnosed with severe sepsis (n = 365) or septic shock (n = 119) according to clinical criteria and included into this study. The most frequent sites of infection were the lung and abdomen. The overall ICU and hospital mortality rates were 28.7% (n = 139) and 33.5% (n = 162), respectively. In multivariate analyses, APACHE II score (odds ratio[OR], 1.068; 95% confidential interval[CI], 1.027-1.109), presence of ARDS (OR, 2.676; 95%CI, 1.691-4.235), bloodstream infection (OR, 2.520; 95%CI, 1.142-5.564) and comorbidity of cancer (OR, 2.246; 95%CI, 1.141-4.420) were significantly associated with mortality.

CONCLUSIONS

Our results indicated that severe sepsis and septic shock were common complications in ICU patients and with high mortality in China, and can be of help to know more about severe sepsis and septic shock in China and to improve characterization and risk stratification in these patients.

Authors+Show Affiliations

Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.Department of Emergency Medicine and Medical ICU, The First Affiliated Hospital of Kunming Medical University, Kunming, China.Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.Department of Critical Care Medicine, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China.Department of Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Department of Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China.Department of Critical Care Medicine, Peking University People's Hospital, Beijing, China.Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China.Department of Critical Care Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China.Department of Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.Department of Critical Care Medicine, Hebei Medical University Fourth Hospital, Shijiazhuang, China.Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, China.Department of Emergency and Intensive Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, Beijing, China.Department of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.Emergency ICU, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.Department of Critical Care Medicine, Guangdong General Hospital, Guangzhou, China.Department of Critical Care Medicine, Hainan Provincial People's Hospital, Haikou, China.Department of Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China.Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25226033

Citation

Zhou, Jianfang, et al. "Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China." PloS One, vol. 9, no. 9, 2014, pp. e107181.
Zhou J, Qian C, Zhao M, et al. Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China. PLoS One. 2014;9(9):e107181.
Zhou, J., Qian, C., Zhao, M., Yu, X., Kang, Y., Ma, X., Ai, Y., Xu, Y., Liu, D., An, Y., Wu, D., Sun, R., Li, S., Hu, Z., Cao, X., Zhou, F., Jiang, L., Lin, J., Mao, E., ... Du, B. (2014). Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China. PloS One, 9(9), e107181. https://doi.org/10.1371/journal.pone.0107181
Zhou J, et al. Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China. PLoS One. 2014;9(9):e107181. PubMed PMID: 25226033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China. AU - Zhou,Jianfang, AU - Qian,Chuanyun, AU - Zhao,Mingyan, AU - Yu,Xiangyou, AU - Kang,Yan, AU - Ma,Xiaochun, AU - Ai,Yuhang, AU - Xu,Yuan, AU - Liu,Dexin, AU - An,Youzhong, AU - Wu,Dawei, AU - Sun,Renhua, AU - Li,Shusheng, AU - Hu,Zhenjie, AU - Cao,Xiangyuan, AU - Zhou,Fachun, AU - Jiang,Li, AU - Lin,Jiandong, AU - Mao,Enqiang, AU - Qin,Tiehe, AU - He,Zhenyang, AU - Zhou,Lihua, AU - Du,Bin, AU - ,, Y1 - 2014/09/16/ PY - 2014/04/17/received PY - 2014/08/07/accepted PY - 2014/9/17/entrez PY - 2014/9/17/pubmed PY - 2015/5/28/medline SP - e107181 EP - e107181 JF - PloS one JO - PLoS One VL - 9 IS - 9 N2 - INTRODUCTION: Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology and outcome of severe sepsis and septic shock in mixed ICU in mainland China, as well as the independent predictors of mortality. METHODS: We performed a 2-month prospective, observational cohort study in 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during the study period were screened and patients with severe sepsis or septic shock were included. RESULTS: A total of 484 patients, 37.3 per 100 ICU admissions were diagnosed with severe sepsis (n = 365) or septic shock (n = 119) according to clinical criteria and included into this study. The most frequent sites of infection were the lung and abdomen. The overall ICU and hospital mortality rates were 28.7% (n = 139) and 33.5% (n = 162), respectively. In multivariate analyses, APACHE II score (odds ratio[OR], 1.068; 95% confidential interval[CI], 1.027-1.109), presence of ARDS (OR, 2.676; 95%CI, 1.691-4.235), bloodstream infection (OR, 2.520; 95%CI, 1.142-5.564) and comorbidity of cancer (OR, 2.246; 95%CI, 1.141-4.420) were significantly associated with mortality. CONCLUSIONS: Our results indicated that severe sepsis and septic shock were common complications in ICU patients and with high mortality in China, and can be of help to know more about severe sepsis and septic shock in China and to improve characterization and risk stratification in these patients. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25226033/Epidemiology_and_outcome_of_severe_sepsis_and_septic_shock_in_intensive_care_units_in_mainland_China_ L2 - https://dx.plos.org/10.1371/journal.pone.0107181 DB - PRIME DP - Unbound Medicine ER -