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Repeatability of peripapillary retinal nerve fiber layer and inner retinal thickness among two spectral domain optical coherence tomography devices.
Invest Ophthalmol Vis Sci. 2014 Sep 16; 55(10):6536-46.IO

Abstract

PURPOSE

To compare measurement of macular inner retina and peripapillary retinal nerve fiber layer (pRNFL) thickness using two spectral-domain optical coherence tomography (SD-OCT) devices in glaucoma patients, patients with ocular hypertension, idiopathic and atypical Parkinson disease, and healthy controls.

METHODS

A total of 171 eyes of 146 participants underwent successful pRNFL and macular scanning and automated measurement of ganglion cell layer+inner plexiform layer (GCL-IPL) using Cirrus HD-OCT or retinal nerve fiber layer+GCL-IPL (RNFL-GCL-IPL) using RTVue-100. Macular RNFL was added to the GCL-IPL thickness measured by Cirrus and was compared to the RNFL-GCL-IPL thickness of the RTVue in the corresponding Cirrus sectors. Intraclass correlation coefficient (ICC) was calculated to determine repeatability of three consecutive measurements; ICC and Bland-Altman analysis to assess agreement between OCTs; Pearson's correlation coefficient to assess strength of linear correlation.

RESULTS

Repeatability of average macular RNFL-GCL-IPL thickness measurement was excellent with an ICC of 0.998 for Cirrus and 0.995 for RTVue. Repeatability was also good for average pRNFL thickness measurements. Both instruments demonstrated a good consistency in measurements with ICC values ranging from 0.844 to 0.862 for macular RNFL-GCL-IPL and 0.718 to 0.958 for pRNFL thickness.

CONCLUSIONS

Measurement of pRNFL and macular RNFL-GCL-IPL thickness has a high degree of repeatability for both OCT devices. Despite a high correlation between measurements of the two OCT devices and fair to excellent ICC values representing a high consistency in the measurements of the two devices, RTVue measured a thicker macular RNFL-GCL-IPL and pRNFL thickness.

Authors+Show Affiliations

Department of Ophthalmology, University of Würzburg, Germany.Institute of Clinical Epidemiology and Biometry, University of Würzburg, Germany Comprehensive Heart Failure Center, University of Würzburg, Germany.Institute of Clinical Epidemiology and Biometry, University of Würzburg, Germany.Department of Ophthalmology, University of Würzburg, Germany.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25228545

Citation

Matlach, Juliane, et al. "Repeatability of Peripapillary Retinal Nerve Fiber Layer and Inner Retinal Thickness Among Two Spectral Domain Optical Coherence Tomography Devices." Investigative Ophthalmology & Visual Science, vol. 55, no. 10, 2014, pp. 6536-46.
Matlach J, Wagner M, Malzahn U, et al. Repeatability of peripapillary retinal nerve fiber layer and inner retinal thickness among two spectral domain optical coherence tomography devices. Invest Ophthalmol Vis Sci. 2014;55(10):6536-46.
Matlach, J., Wagner, M., Malzahn, U., & Göbel, W. (2014). Repeatability of peripapillary retinal nerve fiber layer and inner retinal thickness among two spectral domain optical coherence tomography devices. Investigative Ophthalmology & Visual Science, 55(10), 6536-46. https://doi.org/10.1167/iovs.14-15072
Matlach J, et al. Repeatability of Peripapillary Retinal Nerve Fiber Layer and Inner Retinal Thickness Among Two Spectral Domain Optical Coherence Tomography Devices. Invest Ophthalmol Vis Sci. 2014 Sep 16;55(10):6536-46. PubMed PMID: 25228545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeatability of peripapillary retinal nerve fiber layer and inner retinal thickness among two spectral domain optical coherence tomography devices. AU - Matlach,Juliane, AU - Wagner,Martin, AU - Malzahn,Uwe, AU - Göbel,Winfried, Y1 - 2014/09/16/ PY - 2014/9/18/entrez PY - 2014/9/18/pubmed PY - 2014/12/23/medline KW - Cirrus KW - OCT KW - RNFL KW - RTVue KW - agreement KW - ganglion cell layer KW - inner retina KW - repeatability SP - 6536 EP - 46 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 55 IS - 10 N2 - PURPOSE: To compare measurement of macular inner retina and peripapillary retinal nerve fiber layer (pRNFL) thickness using two spectral-domain optical coherence tomography (SD-OCT) devices in glaucoma patients, patients with ocular hypertension, idiopathic and atypical Parkinson disease, and healthy controls. METHODS: A total of 171 eyes of 146 participants underwent successful pRNFL and macular scanning and automated measurement of ganglion cell layer+inner plexiform layer (GCL-IPL) using Cirrus HD-OCT or retinal nerve fiber layer+GCL-IPL (RNFL-GCL-IPL) using RTVue-100. Macular RNFL was added to the GCL-IPL thickness measured by Cirrus and was compared to the RNFL-GCL-IPL thickness of the RTVue in the corresponding Cirrus sectors. Intraclass correlation coefficient (ICC) was calculated to determine repeatability of three consecutive measurements; ICC and Bland-Altman analysis to assess agreement between OCTs; Pearson's correlation coefficient to assess strength of linear correlation. RESULTS: Repeatability of average macular RNFL-GCL-IPL thickness measurement was excellent with an ICC of 0.998 for Cirrus and 0.995 for RTVue. Repeatability was also good for average pRNFL thickness measurements. Both instruments demonstrated a good consistency in measurements with ICC values ranging from 0.844 to 0.862 for macular RNFL-GCL-IPL and 0.718 to 0.958 for pRNFL thickness. CONCLUSIONS: Measurement of pRNFL and macular RNFL-GCL-IPL thickness has a high degree of repeatability for both OCT devices. Despite a high correlation between measurements of the two OCT devices and fair to excellent ICC values representing a high consistency in the measurements of the two devices, RTVue measured a thicker macular RNFL-GCL-IPL and pRNFL thickness. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/25228545/Repeatability_of_peripapillary_retinal_nerve_fiber_layer_and_inner_retinal_thickness_among_two_spectral_domain_optical_coherence_tomography_devices_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-15072 DB - PRIME DP - Unbound Medicine ER -