Tags

Type your tag names separated by a space and hit enter

Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort.
BJU Int. 2015 Jul; 116(1):124-30.BI

Abstract

OBJECTIVES

To evaluate the relationship between metabolic syndrome and the frequency and severity of lower urinary tract symptoms (LUTS).

PATIENTS AND METHODS

In all, 4666 men aged 55-100 years consulting a general practitioner during a 12-day period in December 2009 have been included in this observational study. LUTS were defined according to the International Prostate Symptom Score (IPSS) and metabolic syndrome with the National Cholesterol Education Program/Adult Treatment Panel III definition. We studied the correlation between metabolic syndrome and its individual components, and the severity of LUTS (IPSS and treatment for LUTS). Analyses were adjusted for body mass index, age, and prostate-specific antigen level.

RESULTS

Metabolic syndrome was reported in 51.5% of the patients and 47% were treated for LUTS. There was a significant link between metabolic syndrome and treated LUTS (P < 0.001). The risk of being treated for LUTS also increased with an increasing number of metabolic syndrome components present. Metabolic syndrome was positively correlated with the severity of the LUTS (P < 0.001) for overall IPSS and both voiding and storage scores (P < 0.001). Each component of the metabolic syndrome (except high-density lipoprotein-cholesterol) appeared as an independent risk factor of high IPSS and of LUTS treatment in multivariate analysis. Metabolic syndrome was positively correlated with prostate volume.

CONCLUSIONS

Our results suggest a significant relationship between LUTS linked to benign prostatic hyperplasia and metabolic syndrome, in terms of frequency and severity. The risk of being treated for LUTS also increased with an increasing number of metabolic syndrome components present. The prevention of such modifiable factors by the promotion of dietary changes and regular physical activity practice may be of great importance for public health.

Authors+Show Affiliations

Urology Department, Saint-Louis Hospital, Paris, France.Urology Department, Saint-Louis Hospital, Paris, France.Endocrinology and Metabolism Department, Pitié-Salpêtrière Hospital, APHP, Paris, France.Urology Department, Saint-Louis Hospital, Paris, France.Urology Department, Saint-Louis Hospital, Paris, France.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25229124

Citation

Pashootan, Pourya, et al. "Association Between Metabolic Syndrome and Severity of Lower Urinary Tract Symptoms (LUTS): an Observational Study in a 4666 European Men Cohort." BJU International, vol. 116, no. 1, 2015, pp. 124-30.
Pashootan P, Ploussard G, Cocaul A, et al. Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort. BJU Int. 2015;116(1):124-30.
Pashootan, P., Ploussard, G., Cocaul, A., de Gouvello, A., & Desgrandchamps, F. (2015). Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort. BJU International, 116(1), 124-30. https://doi.org/10.1111/bju.12931
Pashootan P, et al. Association Between Metabolic Syndrome and Severity of Lower Urinary Tract Symptoms (LUTS): an Observational Study in a 4666 European Men Cohort. BJU Int. 2015;116(1):124-30. PubMed PMID: 25229124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort. AU - Pashootan,Pourya, AU - Ploussard,Guillaume, AU - Cocaul,Arnaud, AU - de Gouvello,Armaury, AU - Desgrandchamps,François, Y1 - 2014/12/08/ PY - 2014/9/18/entrez PY - 2014/9/18/pubmed PY - 2015/9/15/medline KW - IPSS KW - LUTS KW - benign prostatic hyperplasia KW - general practitioner KW - metabolic syndrome X KW - obesity SP - 124 EP - 30 JF - BJU international JO - BJU Int VL - 116 IS - 1 N2 - OBJECTIVES: To evaluate the relationship between metabolic syndrome and the frequency and severity of lower urinary tract symptoms (LUTS). PATIENTS AND METHODS: In all, 4666 men aged 55-100 years consulting a general practitioner during a 12-day period in December 2009 have been included in this observational study. LUTS were defined according to the International Prostate Symptom Score (IPSS) and metabolic syndrome with the National Cholesterol Education Program/Adult Treatment Panel III definition. We studied the correlation between metabolic syndrome and its individual components, and the severity of LUTS (IPSS and treatment for LUTS). Analyses were adjusted for body mass index, age, and prostate-specific antigen level. RESULTS: Metabolic syndrome was reported in 51.5% of the patients and 47% were treated for LUTS. There was a significant link between metabolic syndrome and treated LUTS (P < 0.001). The risk of being treated for LUTS also increased with an increasing number of metabolic syndrome components present. Metabolic syndrome was positively correlated with the severity of the LUTS (P < 0.001) for overall IPSS and both voiding and storage scores (P < 0.001). Each component of the metabolic syndrome (except high-density lipoprotein-cholesterol) appeared as an independent risk factor of high IPSS and of LUTS treatment in multivariate analysis. Metabolic syndrome was positively correlated with prostate volume. CONCLUSIONS: Our results suggest a significant relationship between LUTS linked to benign prostatic hyperplasia and metabolic syndrome, in terms of frequency and severity. The risk of being treated for LUTS also increased with an increasing number of metabolic syndrome components present. The prevention of such modifiable factors by the promotion of dietary changes and regular physical activity practice may be of great importance for public health. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/25229124/Association_between_metabolic_syndrome_and_severity_of_lower_urinary_tract_symptoms__LUTS_:_an_observational_study_in_a_4666_European_men_cohort_ L2 - https://doi.org/10.1111/bju.12931 DB - PRIME DP - Unbound Medicine ER -