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Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships.
Nat Prod Res. 2015; 29(1):98-101.NP

Abstract

Extensive chromatographic isolation and purification of the extracts of the stem bark of Calophyllum inophyllum and Calophyllum soulattri have resulted in 11 xanthones. C. inophyllum gave inophinnin (1), inophinone (2), pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7) and 4-hydroxyxanthone (8), while C. soulattri afforded soulattrin (3), phylattrin (4), caloxanthone C (9), brasixanthone B (10) and trapezifolixanthone (11). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D NMR, GC-MS, IR and UV. Cytotoxicity screening (MTT assay) carried out in vitro on all the xanthones using five human cancer cell lines indicated good activities for some of these xanthones. The structure-activity relationship study revealed that the inhibitory activities exhibited by these xanthone derivatives to be closely related to the existence and nature of the pyrano and the prenyl substituent groups on their skeleton.

Authors+Show Affiliations

a School of Biosciences, Taylor's University , Lakeside Campus, 47500 Subang Jaya , Selangor , Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25229947

Citation

Mah, Siau Hui, et al. "Calophyllum Inophyllum and Calophyllum Soulattri Source of Anti-proliferative Xanthones and Their Structure-activity Relationships." Natural Product Research, vol. 29, no. 1, 2015, pp. 98-101.
Mah SH, Ee GC, Teh SS, et al. Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships. Nat Prod Res. 2015;29(1):98-101.
Mah, S. H., Ee, G. C., Teh, S. S., & Sukari, M. A. (2015). Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships. Natural Product Research, 29(1), 98-101. https://doi.org/10.1080/14786419.2014.959949
Mah SH, et al. Calophyllum Inophyllum and Calophyllum Soulattri Source of Anti-proliferative Xanthones and Their Structure-activity Relationships. Nat Prod Res. 2015;29(1):98-101. PubMed PMID: 25229947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships. AU - Mah,Siau Hui, AU - Ee,Gwendoline Cheng Lian, AU - Teh,Soek Sin, AU - Sukari,Mohd Aspollah, Y1 - 2014/09/17/ PY - 2014/9/18/entrez PY - 2014/9/18/pubmed PY - 2015/3/31/medline KW - Calophyllum KW - cytotoxicity KW - structure–activity relationship KW - xanthone SP - 98 EP - 101 JF - Natural product research JO - Nat Prod Res VL - 29 IS - 1 N2 - Extensive chromatographic isolation and purification of the extracts of the stem bark of Calophyllum inophyllum and Calophyllum soulattri have resulted in 11 xanthones. C. inophyllum gave inophinnin (1), inophinone (2), pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7) and 4-hydroxyxanthone (8), while C. soulattri afforded soulattrin (3), phylattrin (4), caloxanthone C (9), brasixanthone B (10) and trapezifolixanthone (11). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D NMR, GC-MS, IR and UV. Cytotoxicity screening (MTT assay) carried out in vitro on all the xanthones using five human cancer cell lines indicated good activities for some of these xanthones. The structure-activity relationship study revealed that the inhibitory activities exhibited by these xanthone derivatives to be closely related to the existence and nature of the pyrano and the prenyl substituent groups on their skeleton. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/25229947/Calophyllum_inophyllum_and_Calophyllum_soulattri_source_of_anti_proliferative_xanthones_and_their_structure_activity_relationships_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2014.959949 DB - PRIME DP - Unbound Medicine ER -