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Hypolipidemic and antioxidative effects of aqueous enzymatic extract from rice bran in rats fed a high-fat and -cholesterol diet.
Nutrients. 2014 Sep 16; 6(9):3696-710.N

Abstract

PURPOSE

The aqueous enzymatic extract from rice bran (AEERB) was rich in protein, γ-oryzanol and tocols. The aim of this study was to investigate the effects of AEERB on the regulation of lipid metabolism and the inhibition of oxidative damage.

METHODS

The antioxidant activity of AEERB in vitro was measured in terms of radical scavenging capacity, ferric reducing ability power (FRAP) and linoleic acid emulsion system-ferric thiocyanate method (FTC). Male Wistar rats were fed with a normal diet and a high-fat and high-cholesterol diet with or without AEERB. After treatment, biochemical assays of serum, liver and feces lipid levels, the antioxidant enzyme activity, malondialdehyde (MDA) and protein carbonyl were determined.

RESULT

AEERB is completely soluble in water and rich in hydrophilic and lipophilic functional ingredients. AEERB scavenged DPPH• and ABTS•+ and exhibited antioxidant activity slightly lower than that of ascorbic acid in the linoleic acid system. The administration of AEERB reduced serum lipid levels and the atherogenic index compared with those of the hyperlipidemic diet group (HD). The administration of AEERB significantly lowered liver lipid levels, inhibited hepatic 3-hydroxyl-3-methylglutaryl CoA reductase activity, and efficiently promoted the fecal excretion of total lipids and total cholesterol (TC) (p < 0.05). Dietary AEERB enhanced antioxidant status in the serum, liver and brain by increasing the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and decreasing the content of MDA and protein carbonyl.

CONCLUSIONS

The results indicated that AEERB might act as a potent hypolipidemic and antioxidant functional food.

Authors+Show Affiliations

College of Science, Northeast Agricultural University, Harbin 150030, China. wyxin0612@126.com.Department of Respiratory Medicine, Daxing Hospital Affiliated to Capital Medical University, Beijing 102600, China. yamshang@163.com.College of Food Science, Northeast Agricultural University, Harbin 150030, China. strive2011@126.com.College of Food Science, Northeast Agricultural University, Harbin 150030, China. fengjiaowang163@163.com.College of Food Science, Northeast Agricultural University, Harbin 150030, China. yuguoping@neau.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25230211

Citation

Wang, Yu-Xin, et al. "Hypolipidemic and Antioxidative Effects of Aqueous Enzymatic Extract From Rice Bran in Rats Fed a High-fat and -cholesterol Diet." Nutrients, vol. 6, no. 9, 2014, pp. 3696-710.
Wang YX, Li Y, Sun AM, et al. Hypolipidemic and antioxidative effects of aqueous enzymatic extract from rice bran in rats fed a high-fat and -cholesterol diet. Nutrients. 2014;6(9):3696-710.
Wang, Y. X., Li, Y., Sun, A. M., Wang, F. J., & Yu, G. P. (2014). Hypolipidemic and antioxidative effects of aqueous enzymatic extract from rice bran in rats fed a high-fat and -cholesterol diet. Nutrients, 6(9), 3696-710. https://doi.org/10.3390/nu6093696
Wang YX, et al. Hypolipidemic and Antioxidative Effects of Aqueous Enzymatic Extract From Rice Bran in Rats Fed a High-fat and -cholesterol Diet. Nutrients. 2014 Sep 16;6(9):3696-710. PubMed PMID: 25230211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypolipidemic and antioxidative effects of aqueous enzymatic extract from rice bran in rats fed a high-fat and -cholesterol diet. AU - Wang,Yu-Xin, AU - Li,Yang, AU - Sun,An-Min, AU - Wang,Feng-Jiao, AU - Yu,Guo-Ping, Y1 - 2014/09/16/ PY - 2014/06/05/received PY - 2014/08/04/revised PY - 2014/08/27/accepted PY - 2014/9/18/entrez PY - 2014/9/18/pubmed PY - 2015/5/12/medline SP - 3696 EP - 710 JF - Nutrients JO - Nutrients VL - 6 IS - 9 N2 - PURPOSE: The aqueous enzymatic extract from rice bran (AEERB) was rich in protein, γ-oryzanol and tocols. The aim of this study was to investigate the effects of AEERB on the regulation of lipid metabolism and the inhibition of oxidative damage. METHODS: The antioxidant activity of AEERB in vitro was measured in terms of radical scavenging capacity, ferric reducing ability power (FRAP) and linoleic acid emulsion system-ferric thiocyanate method (FTC). Male Wistar rats were fed with a normal diet and a high-fat and high-cholesterol diet with or without AEERB. After treatment, biochemical assays of serum, liver and feces lipid levels, the antioxidant enzyme activity, malondialdehyde (MDA) and protein carbonyl were determined. RESULT: AEERB is completely soluble in water and rich in hydrophilic and lipophilic functional ingredients. AEERB scavenged DPPH• and ABTS•+ and exhibited antioxidant activity slightly lower than that of ascorbic acid in the linoleic acid system. The administration of AEERB reduced serum lipid levels and the atherogenic index compared with those of the hyperlipidemic diet group (HD). The administration of AEERB significantly lowered liver lipid levels, inhibited hepatic 3-hydroxyl-3-methylglutaryl CoA reductase activity, and efficiently promoted the fecal excretion of total lipids and total cholesterol (TC) (p < 0.05). Dietary AEERB enhanced antioxidant status in the serum, liver and brain by increasing the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and decreasing the content of MDA and protein carbonyl. CONCLUSIONS: The results indicated that AEERB might act as a potent hypolipidemic and antioxidant functional food. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/25230211/Hypolipidemic_and_antioxidative_effects_of_aqueous_enzymatic_extract_from_rice_bran_in_rats_fed_a_high_fat_and__cholesterol_diet_ L2 - http://www.mdpi.com/resolver?pii=nu6093696 DB - PRIME DP - Unbound Medicine ER -