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Biological mechanisms linking Alzheimer's disease and type-2 diabetes mellitus.

Abstract

The emerging data suggest that type 2 diabetes mellitus (T2DM) can contribute significantly to the onset or progression of Alzheimer's disease (AD) either directly or as a cofactor. Various in vitro and in vivo animal and human clinical studies have provided evidence that T2DM is a major risk factor in the pathology of AD and the two diseases share common biological mechanisms at the molecular level. The biological mechanisms that are common in the pathology of both T2DM and AD include insulin resistance, impaired glucose metabolism, β-amyloid formation, oxidative stress, and the presence of advanced glycation end products. With better understanding of the degree of association between AD and T2DM and the underlying molecular mechanisms explaining this relationship, it is hoped that researchers will be able to develop effective therapeutic interventions to treat or control T2DM and, as a consequence, delay the onset or progression of AD.

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  • Authors+Show Affiliations

    , ,

    Department of Biochemistry, College of Science, King Abdulaziz University, Jeddah, Saudi Arabia. gmushtaq2001@gmail.com.

    Source

    MeSH

    Alzheimer Disease
    Amyloid beta-Peptides
    Animals
    Diabetes Mellitus, Type 2
    Glucose
    Humans
    Insulin Resistance
    Oxidative Stress
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    25230227

    Citation

    Mushtaq, Gohar, et al. "Biological Mechanisms Linking Alzheimer's Disease and Type-2 Diabetes Mellitus." CNS & Neurological Disorders Drug Targets, vol. 13, no. 7, 2014, pp. 1192-201.
    Mushtaq G, Khan JA, Kamal MA. Biological mechanisms linking Alzheimer's disease and type-2 diabetes mellitus. CNS Neurol Disord Drug Targets. 2014;13(7):1192-201.
    Mushtaq, G., Khan, J. A., & Kamal, M. A. (2014). Biological mechanisms linking Alzheimer's disease and type-2 diabetes mellitus. CNS & Neurological Disorders Drug Targets, 13(7), pp. 1192-201.
    Mushtaq G, Khan JA, Kamal MA. Biological Mechanisms Linking Alzheimer's Disease and Type-2 Diabetes Mellitus. CNS Neurol Disord Drug Targets. 2014;13(7):1192-201. PubMed PMID: 25230227.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Biological mechanisms linking Alzheimer's disease and type-2 diabetes mellitus. AU - Mushtaq,Gohar, AU - Khan,Jalaluddin A, AU - Kamal,Mohammad A, PY - 2014/03/07/received PY - 2014/04/11/revised PY - 2014/04/12/accepted PY - 2014/9/18/entrez PY - 2014/9/18/pubmed PY - 2015/7/15/medline SP - 1192 EP - 201 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 13 IS - 7 N2 - The emerging data suggest that type 2 diabetes mellitus (T2DM) can contribute significantly to the onset or progression of Alzheimer's disease (AD) either directly or as a cofactor. Various in vitro and in vivo animal and human clinical studies have provided evidence that T2DM is a major risk factor in the pathology of AD and the two diseases share common biological mechanisms at the molecular level. The biological mechanisms that are common in the pathology of both T2DM and AD include insulin resistance, impaired glucose metabolism, β-amyloid formation, oxidative stress, and the presence of advanced glycation end products. With better understanding of the degree of association between AD and T2DM and the underlying molecular mechanisms explaining this relationship, it is hoped that researchers will be able to develop effective therapeutic interventions to treat or control T2DM and, as a consequence, delay the onset or progression of AD. SN - 1996-3181 UR - https://www.unboundmedicine.com/medline/citation/25230227/Biological_mechanisms_linking_Alzheimer's_disease_and_type_2_diabetes_mellitus_ L2 - http://www.eurekaselect.com/124695/article DB - PRIME DP - Unbound Medicine ER -