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Asthma in inner-city children at 5-11 years of age and prenatal exposure to phthalates: the Columbia Center for Children's Environmental Health Cohort.
Environ Health Perspect. 2014 Oct; 122(10):1141-6.EH

Abstract

BACKGROUND

Studies suggest that phthalate exposures may adversely affect child respiratory health.

OBJECTIVES

We evaluated associations between asthma diagnosed in children between 5 and 11 years of age and prenatal exposures to butylbenzyl phthalate (BBzP), di-n-butyl phthalate (DnBP), di(2-ethylhexyl) phthalate (DEHP), and diethyl phthalate (DEP).

METHODS

Phthalate metabolites were measured in spot urine collected from 300 pregnant inner-city women. Children were examined by an allergist or pulmonologist based on the first parental report of wheeze, other respiratory symptoms, and/or use of asthma rescue/controller medication in the preceding 12 months on repeat follow-up questionnaires. Standardized diagnostic criteria were used to classify these children as either having or not having current asthma at the time of the physician examination. Children without any report of wheeze or the other asthma-like symptoms were classified as nonasthmatics at the time of the last negative questionnaire. Modified Poisson regression analyses were used to estimate relative risks (RR) controlling for specific gravity and potential confounders.

RESULTS

Of 300 children, 154 (51%) were examined by a physician because of reports of wheeze, other asthma-like symptoms, and/or medication use; 94 were diagnosed with current asthma and 60 without current asthma. The remaining 146 children were classified as nonasthmatic. Compared with levels in nonasthmatics, prenatal metabolites of BBzP and DnBP were associated with a history of asthma-like symptoms (p < 0.05) and with the diagnosis of current asthma: RR = 1.17 (95% CI: 1.01, 1.35) and RR = 1.25 (95% CI: 1.04, 1.51) per natural log-unit increase, respectively. Risk of current asthma was > 70% higher among children with maternal prenatal BBzP and DnBP metabolite concentrations in the third versus the first tertile.

CONCLUSION

Prenatal exposure to BBzP and DnBP may increase the risk of asthma among inner-city children. However, because this is the first such finding, results require replication.

Authors+Show Affiliations

Department of Environmental Health Sciences, Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25230320

Citation

Whyatt, Robin M., et al. "Asthma in Inner-city Children at 5-11 Years of Age and Prenatal Exposure to Phthalates: the Columbia Center for Children's Environmental Health Cohort." Environmental Health Perspectives, vol. 122, no. 10, 2014, pp. 1141-6.
Whyatt RM, Perzanowski MS, Just AC, et al. Asthma in inner-city children at 5-11 years of age and prenatal exposure to phthalates: the Columbia Center for Children's Environmental Health Cohort. Environ Health Perspect. 2014;122(10):1141-6.
Whyatt, R. M., Perzanowski, M. S., Just, A. C., Rundle, A. G., Donohue, K. M., Calafat, A. M., Hoepner, L. A., Perera, F. P., & Miller, R. L. (2014). Asthma in inner-city children at 5-11 years of age and prenatal exposure to phthalates: the Columbia Center for Children's Environmental Health Cohort. Environmental Health Perspectives, 122(10), 1141-6. https://doi.org/10.1289/ehp.1307670
Whyatt RM, et al. Asthma in Inner-city Children at 5-11 Years of Age and Prenatal Exposure to Phthalates: the Columbia Center for Children's Environmental Health Cohort. Environ Health Perspect. 2014;122(10):1141-6. PubMed PMID: 25230320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asthma in inner-city children at 5-11 years of age and prenatal exposure to phthalates: the Columbia Center for Children's Environmental Health Cohort. AU - Whyatt,Robin M, AU - Perzanowski,Matthew S, AU - Just,Allan C, AU - Rundle,Andrew G, AU - Donohue,Kathleen M, AU - Calafat,Antonia M, AU - Hoepner,Lori A, AU - Perera,Frederica P, AU - Miller,Rachel L, Y1 - 2014/09/17/ PY - 2013/09/19/received PY - 2014/07/10/accepted PY - 2014/9/18/entrez PY - 2014/9/18/pubmed PY - 2015/7/15/medline SP - 1141 EP - 6 JF - Environmental health perspectives JO - Environ Health Perspect VL - 122 IS - 10 N2 - BACKGROUND: Studies suggest that phthalate exposures may adversely affect child respiratory health. OBJECTIVES: We evaluated associations between asthma diagnosed in children between 5 and 11 years of age and prenatal exposures to butylbenzyl phthalate (BBzP), di-n-butyl phthalate (DnBP), di(2-ethylhexyl) phthalate (DEHP), and diethyl phthalate (DEP). METHODS: Phthalate metabolites were measured in spot urine collected from 300 pregnant inner-city women. Children were examined by an allergist or pulmonologist based on the first parental report of wheeze, other respiratory symptoms, and/or use of asthma rescue/controller medication in the preceding 12 months on repeat follow-up questionnaires. Standardized diagnostic criteria were used to classify these children as either having or not having current asthma at the time of the physician examination. Children without any report of wheeze or the other asthma-like symptoms were classified as nonasthmatics at the time of the last negative questionnaire. Modified Poisson regression analyses were used to estimate relative risks (RR) controlling for specific gravity and potential confounders. RESULTS: Of 300 children, 154 (51%) were examined by a physician because of reports of wheeze, other asthma-like symptoms, and/or medication use; 94 were diagnosed with current asthma and 60 without current asthma. The remaining 146 children were classified as nonasthmatic. Compared with levels in nonasthmatics, prenatal metabolites of BBzP and DnBP were associated with a history of asthma-like symptoms (p < 0.05) and with the diagnosis of current asthma: RR = 1.17 (95% CI: 1.01, 1.35) and RR = 1.25 (95% CI: 1.04, 1.51) per natural log-unit increase, respectively. Risk of current asthma was > 70% higher among children with maternal prenatal BBzP and DnBP metabolite concentrations in the third versus the first tertile. CONCLUSION: Prenatal exposure to BBzP and DnBP may increase the risk of asthma among inner-city children. However, because this is the first such finding, results require replication. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/25230320/Asthma_in_inner_city_children_at_5_11_years_of_age_and_prenatal_exposure_to_phthalates:_the_Columbia_Center_for_Children's_Environmental_Health_Cohort_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.1307670?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -