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The effect of Zuccagnia punctata, an Argentine medicinal plant, on virulence factors from candida species.
Nat Prod Commun. 2014 Jul; 9(7):933-6.NP

Abstract

Zuccagnia punctata Cav. has been used as a traditional medicine in Argentina for the treatment of bacterial and fungal infections. In this study, we evaluated the ability of Z. punctata extract (ZpE) and compounds isolated from it to inhibit the growth and virulence factors of Candida species. ZpE showed inhibitory activity against planktonic cells of all assayed Candida species with MIC values of 400 microg/mL and with MFC values between 400 and 1,200 microg/mL. The principal identified compounds by HPLC-MS/MS and UV-VIS were chalcones (2',4'-dihydroxy-3'-methoxychalcone, 2',4'- dihydroxychalcone), flavones (galangin, 3,7-dihydroxyflavone and chrysin) and flavanones (naringenin, 7-hydroxyflavanone and pinocembrine). These compounds were more effective as inhibitors than the extracts upon biofilm formation as well as on preformed Candida biofilm and yeast germ tube formation. Furthermore, ZpE and chalcones are able to inhibit exoenzymes, which are responsible for the invasion mechanisms of the pathogens. All these effects could moderate colonization, thereby suppressing the pathogen invasive potential. Our results indicate that ZpE and chalcones could be used in antifungal therapy.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25230496

Citation

Gabriela, Nuño, et al. "The Effect of Zuccagnia Punctata, an Argentine Medicinal Plant, On Virulence Factors From Candida Species." Natural Product Communications, vol. 9, no. 7, 2014, pp. 933-6.
Gabriela N, Rosa AM, Catiana ZI, et al. The effect of Zuccagnia punctata, an Argentine medicinal plant, on virulence factors from candida species. Nat Prod Commun. 2014;9(7):933-6.
Gabriela, N., Rosa, A. M., Catiana, Z. I., Soledad, C., Mabel, O. R., Esteban, S. J., Veronica, B., Daniel, W., & Ines, I. M. (2014). The effect of Zuccagnia punctata, an Argentine medicinal plant, on virulence factors from candida species. Natural Product Communications, 9(7), 933-6.
Gabriela N, et al. The Effect of Zuccagnia Punctata, an Argentine Medicinal Plant, On Virulence Factors From Candida Species. Nat Prod Commun. 2014;9(7):933-6. PubMed PMID: 25230496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of Zuccagnia punctata, an Argentine medicinal plant, on virulence factors from candida species. AU - Gabriela,Nuño, AU - Rosa,Alberto María, AU - Catiana,Zampini Iris, AU - Soledad,Cuello, AU - Mabel,Ordoñez Roxana, AU - Esteban,Sayago Jorge, AU - Veronica,Baroni, AU - Daniel,Wunderlin, AU - Ines,Isla María, PY - 2014/9/19/entrez PY - 2014/9/19/pubmed PY - 2014/10/31/medline SP - 933 EP - 6 JF - Natural product communications JO - Nat Prod Commun VL - 9 IS - 7 N2 - Zuccagnia punctata Cav. has been used as a traditional medicine in Argentina for the treatment of bacterial and fungal infections. In this study, we evaluated the ability of Z. punctata extract (ZpE) and compounds isolated from it to inhibit the growth and virulence factors of Candida species. ZpE showed inhibitory activity against planktonic cells of all assayed Candida species with MIC values of 400 microg/mL and with MFC values between 400 and 1,200 microg/mL. The principal identified compounds by HPLC-MS/MS and UV-VIS were chalcones (2',4'-dihydroxy-3'-methoxychalcone, 2',4'- dihydroxychalcone), flavones (galangin, 3,7-dihydroxyflavone and chrysin) and flavanones (naringenin, 7-hydroxyflavanone and pinocembrine). These compounds were more effective as inhibitors than the extracts upon biofilm formation as well as on preformed Candida biofilm and yeast germ tube formation. Furthermore, ZpE and chalcones are able to inhibit exoenzymes, which are responsible for the invasion mechanisms of the pathogens. All these effects could moderate colonization, thereby suppressing the pathogen invasive potential. Our results indicate that ZpE and chalcones could be used in antifungal therapy. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/25230496/The_effect_of_Zuccagnia_punctata_an_Argentine_medicinal_plant_on_virulence_factors_from_candida_species_ DB - PRIME DP - Unbound Medicine ER -