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Phloroglucinols from anti-microbial deposit-resins of Australian stingless bees (Tetragonula carbonaria).
Phytother Res 2015; 29(1):48-58PR

Abstract

Stingless bees accumulate deposits of plant resins that are mixed with beeswax to produce propolis. Previous studies have reported anti-microbial constituents of stingless bee (Tetragonula carbonaria) propolis from East Australia, but several components remained to be characterized. In the search of natural products yet unreported for Australian propolis, four bee deposit-resins of T. carbonaria bees were analysed by gas and liquid chromatography mass spectrometry with accurate mass measurements. Ethanolic extracts of the deposit-resins were tested in vitro against Staphylococcus aureus ATCC 25983 and Pseudomonas aeruginosa ATCC 27853 by the agar diffusion method. Phloroglucinols, flavonoids and isoprenoids were identified in samples. The crude extracts showed strong anti-staphylococcal effects but were less active against the Gram-negative bacterium. The diagnostic data enabled the identification of markers that can be used for profiling other Australian propolis sources and to target the isolation of bioactive phloroglucinols in future studies against antibiotic resistant S. aureus strains.

Authors+Show Affiliations

Genecology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25230727

Citation

Massaro, C Flavia, et al. "Phloroglucinols From Anti-microbial Deposit-resins of Australian Stingless Bees (Tetragonula Carbonaria)." Phytotherapy Research : PTR, vol. 29, no. 1, 2015, pp. 48-58.
Massaro CF, Smyth TJ, Smyth WF, et al. Phloroglucinols from anti-microbial deposit-resins of Australian stingless bees (Tetragonula carbonaria). Phytother Res. 2015;29(1):48-58.
Massaro, C. F., Smyth, T. J., Smyth, W. F., Heard, T., Leonhardt, S. D., Katouli, M., ... Brooks, P. (2015). Phloroglucinols from anti-microbial deposit-resins of Australian stingless bees (Tetragonula carbonaria). Phytotherapy Research : PTR, 29(1), pp. 48-58. doi:10.1002/ptr.5225.
Massaro CF, et al. Phloroglucinols From Anti-microbial Deposit-resins of Australian Stingless Bees (Tetragonula Carbonaria). Phytother Res. 2015;29(1):48-58. PubMed PMID: 25230727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phloroglucinols from anti-microbial deposit-resins of Australian stingless bees (Tetragonula carbonaria). AU - Massaro,C Flavia, AU - Smyth,Thomas J, AU - Smyth,W Franklin, AU - Heard,Tim, AU - Leonhardt,Sara D, AU - Katouli,Mohammad, AU - Wallace,Helen M, AU - Brooks,Peter, Y1 - 2014/09/18/ PY - 2014/03/04/received PY - 2014/08/07/revised PY - 2014/08/21/accepted PY - 2014/9/19/entrez PY - 2014/9/19/pubmed PY - 2015/3/31/medline KW - Myrtaceae KW - Staphylococcus aureus KW - dereplication KW - flavonoids KW - propolis KW - triketones SP - 48 EP - 58 JF - Phytotherapy research : PTR JO - Phytother Res VL - 29 IS - 1 N2 - Stingless bees accumulate deposits of plant resins that are mixed with beeswax to produce propolis. Previous studies have reported anti-microbial constituents of stingless bee (Tetragonula carbonaria) propolis from East Australia, but several components remained to be characterized. In the search of natural products yet unreported for Australian propolis, four bee deposit-resins of T. carbonaria bees were analysed by gas and liquid chromatography mass spectrometry with accurate mass measurements. Ethanolic extracts of the deposit-resins were tested in vitro against Staphylococcus aureus ATCC 25983 and Pseudomonas aeruginosa ATCC 27853 by the agar diffusion method. Phloroglucinols, flavonoids and isoprenoids were identified in samples. The crude extracts showed strong anti-staphylococcal effects but were less active against the Gram-negative bacterium. The diagnostic data enabled the identification of markers that can be used for profiling other Australian propolis sources and to target the isolation of bioactive phloroglucinols in future studies against antibiotic resistant S. aureus strains. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/25230727/Phloroglucinols_from_anti_microbial_deposit_resins_of_Australian_stingless_bees__Tetragonula_carbonaria__ L2 - https://doi.org/10.1002/ptr.5225 DB - PRIME DP - Unbound Medicine ER -