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Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons.

Abstract

OBJECTIVES

We examined whether accordance to the DASH (Dietary Approach to Stop Hypertension) and Mediterranean diets is associated with slower cognitive decline in a prospective Chicago cohort study of older persons, the Memory and Aging Project.

METHODS

The sample comprised 826 Memory and Aging Project participants (aged 81.5 ± 7.1 years) who completed a 144-item food frequency questionnaire at baseline and 2 or more cognitive assessments over 4.1 years. Dietary scores were computed for accordance to the DASH diet (0-10) and the Mediterranean diet (MedDietScore) (0-55). For both, higher scores reflect greater accordance. Both patterns share at least 3 common food components. Cognitive function was assessed annually with 19 cognitive tests from which global cognitive scores and summary measures are computed.

RESULTS

The mean global cognitive score at baseline was 0.12 (range, -3.23 to 1.60) with an overall mean annual change in score of -0.08 standardized units. Only 13 participants had possible dementia. The mean DASH score was 4.1 (range, 1.0-8.5) and the MedDietScore was 31.3 (range, 18-46). In mixed models adjusted for covariates, a 1-unit difference in DASH score was associated with a slower rate of global cognitive decline by 0.007 standardized units (standard error of estimate = 0.003, p = 0.03). Similarly, a 1-unit-higher MedDietScore was associated with a slower rate of global cognitive decline by 0.002 standardized units (standard error of estimate = 0.001, p = 0.01).

CONCLUSIONS

These findings support the hypothesis that both the DASH and Mediterranean diet patterns are associated with slower rates of cognitive decline in the same cohort of older persons.

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    ,

    From the Department of Clinical Nutrition (C.C.T.), Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine (H.L., Y.W., M.C.M.), Rush Alzheimer Disease Center and Department of Neurology (L.B., J.A.S., D.A.B.), and Department of Pathology (J.A.S., D.A.B.), Rush University Medical Center, Chicago, IL. ctangney@rush.edu.

    ,

    From the Department of Clinical Nutrition (C.C.T.), Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine (H.L., Y.W., M.C.M.), Rush Alzheimer Disease Center and Department of Neurology (L.B., J.A.S., D.A.B.), and Department of Pathology (J.A.S., D.A.B.), Rush University Medical Center, Chicago, IL.

    ,

    From the Department of Clinical Nutrition (C.C.T.), Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine (H.L., Y.W., M.C.M.), Rush Alzheimer Disease Center and Department of Neurology (L.B., J.A.S., D.A.B.), and Department of Pathology (J.A.S., D.A.B.), Rush University Medical Center, Chicago, IL.

    ,

    From the Department of Clinical Nutrition (C.C.T.), Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine (H.L., Y.W., M.C.M.), Rush Alzheimer Disease Center and Department of Neurology (L.B., J.A.S., D.A.B.), and Department of Pathology (J.A.S., D.A.B.), Rush University Medical Center, Chicago, IL.

    ,

    From the Department of Clinical Nutrition (C.C.T.), Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine (H.L., Y.W., M.C.M.), Rush Alzheimer Disease Center and Department of Neurology (L.B., J.A.S., D.A.B.), and Department of Pathology (J.A.S., D.A.B.), Rush University Medical Center, Chicago, IL.

    ,

    From the Department of Clinical Nutrition (C.C.T.), Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine (H.L., Y.W., M.C.M.), Rush Alzheimer Disease Center and Department of Neurology (L.B., J.A.S., D.A.B.), and Department of Pathology (J.A.S., D.A.B.), Rush University Medical Center, Chicago, IL.

    From the Department of Clinical Nutrition (C.C.T.), Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine (H.L., Y.W., M.C.M.), Rush Alzheimer Disease Center and Department of Neurology (L.B., J.A.S., D.A.B.), and Department of Pathology (J.A.S., D.A.B.), Rush University Medical Center, Chicago, IL.

    Source

    Neurology 83:16 2014 Oct 14 pg 1410-6

    MeSH

    Aged, 80 and over
    Aging
    Chicago
    Cognition
    Cognition Disorders
    Dementia
    Diet
    Diet, Mediterranean
    Disease Progression
    Feeding Behavior
    Female
    Humans
    Male
    Prospective Studies
    Psychological Tests
    Surveys and Questionnaires
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    25230996

    Citation

    Tangney, Christy C., et al. "Relation of DASH- and Mediterranean-like Dietary Patterns to Cognitive Decline in Older Persons." Neurology, vol. 83, no. 16, 2014, pp. 1410-6.
    Tangney CC, Li H, Wang Y, et al. Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology. 2014;83(16):1410-6.
    Tangney, C. C., Li, H., Wang, Y., Barnes, L., Schneider, J. A., Bennett, D. A., & Morris, M. C. (2014). Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology, 83(16), pp. 1410-6. doi:10.1212/WNL.0000000000000884.
    Tangney CC, et al. Relation of DASH- and Mediterranean-like Dietary Patterns to Cognitive Decline in Older Persons. Neurology. 2014 Oct 14;83(16):1410-6. PubMed PMID: 25230996.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. AU - Tangney,Christy C, AU - Li,Hong, AU - Wang,Yamin, AU - Barnes,Lisa, AU - Schneider,Julie A, AU - Bennett,David A, AU - Morris,Martha C, Y1 - 2014/09/17/ PY - 2014/9/19/entrez PY - 2014/9/19/pubmed PY - 2014/12/15/medline SP - 1410 EP - 6 JF - Neurology JO - Neurology VL - 83 IS - 16 N2 - OBJECTIVES: We examined whether accordance to the DASH (Dietary Approach to Stop Hypertension) and Mediterranean diets is associated with slower cognitive decline in a prospective Chicago cohort study of older persons, the Memory and Aging Project. METHODS: The sample comprised 826 Memory and Aging Project participants (aged 81.5 ± 7.1 years) who completed a 144-item food frequency questionnaire at baseline and 2 or more cognitive assessments over 4.1 years. Dietary scores were computed for accordance to the DASH diet (0-10) and the Mediterranean diet (MedDietScore) (0-55). For both, higher scores reflect greater accordance. Both patterns share at least 3 common food components. Cognitive function was assessed annually with 19 cognitive tests from which global cognitive scores and summary measures are computed. RESULTS: The mean global cognitive score at baseline was 0.12 (range, -3.23 to 1.60) with an overall mean annual change in score of -0.08 standardized units. Only 13 participants had possible dementia. The mean DASH score was 4.1 (range, 1.0-8.5) and the MedDietScore was 31.3 (range, 18-46). In mixed models adjusted for covariates, a 1-unit difference in DASH score was associated with a slower rate of global cognitive decline by 0.007 standardized units (standard error of estimate = 0.003, p = 0.03). Similarly, a 1-unit-higher MedDietScore was associated with a slower rate of global cognitive decline by 0.002 standardized units (standard error of estimate = 0.001, p = 0.01). CONCLUSIONS: These findings support the hypothesis that both the DASH and Mediterranean diet patterns are associated with slower rates of cognitive decline in the same cohort of older persons. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/25230996/Relation_of_DASH__and_Mediterranean_like_dietary_patterns_to_cognitive_decline_in_older_persons_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=25230996 DB - PRIME DP - Unbound Medicine ER -