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Calcium supplementation and bone mineral accretion in Chinese adolescents aged 12-14 years: a 12-month, dose-response, randomised intervention trial.
Br J Nutr. 2014 Nov 14; 112(9):1510-20.BJ

Abstract

A 12-month, dose-response, randomised, intervention trial was conducted to determine adequate Ca intake levels for Chinese adolescents by investigating the effect of Ca supplementation on bone mineral accretion. A total of 220 Han adolescents (111 girls and 109 boys) aged 12-14 years were recruited. All subjects were randomly divided into three groups. The bone mineral content (BMC) and bone mineral density (BMD) of the whole body, lumbar spine (L1-L4), left hip and femoral neck were measured by dual-energy X-ray absorptiometry. Girls in the high-Ca group (actual Ca intake: 1243 (sd 193) mg/d) exhibited greater increases in the femoral neck BMC compared with those in the low-Ca group (9·7 v. 6·4 %, P =0·04) over the 1-year intervention period. The increases in femoral neck BMC were greater in boys in the high-Ca and medium-Ca groups (actual Ca intake: 985 (sd 168) mg/d) than in those in the low-Ca group (15·7 v. 11·7 %, P =0·03; 15·8 v. 11·7 %, P =0·03). Ca supplementation had significant effects on the whole-body BMC and BMD in subjects with physical activity levels>34·86 metabolic equivalents and on the spine BMD and BMC and BMD of most sites in subjects with Tanner stage < 3. Increasing Ca intake levels with Ca supplementation enhanced femoral neck mineral acquisition in Chinese adolescents. Furthermore, high physical activity levels and low Tanner stage appeared to significantly contribute to the effect of Ca supplementation on bone mass. Whether this is a lasting beneficial effect leading to the optimisation of peak bone mass needs to be determined in other long-term prospective studies.

Authors+Show Affiliations

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.Key Lab of Trace Element Nutrition of Ministry of Health, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention,Beijing100021,People's Republic of China.Key Lab of Trace Element Nutrition of Ministry of Health, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention,Beijing100021,People's Republic of China.Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25231730

Citation

Ma, Xiao-ming, et al. "Calcium Supplementation and Bone Mineral Accretion in Chinese Adolescents Aged 12-14 Years: a 12-month, Dose-response, Randomised Intervention Trial." The British Journal of Nutrition, vol. 112, no. 9, 2014, pp. 1510-20.
Ma XM, Huang ZW, Yang XG, et al. Calcium supplementation and bone mineral accretion in Chinese adolescents aged 12-14 years: a 12-month, dose-response, randomised intervention trial. Br J Nutr. 2014;112(9):1510-20.
Ma, X. M., Huang, Z. W., Yang, X. G., & Su, Y. X. (2014). Calcium supplementation and bone mineral accretion in Chinese adolescents aged 12-14 years: a 12-month, dose-response, randomised intervention trial. The British Journal of Nutrition, 112(9), 1510-20. https://doi.org/10.1017/S0007114514002384
Ma XM, et al. Calcium Supplementation and Bone Mineral Accretion in Chinese Adolescents Aged 12-14 Years: a 12-month, Dose-response, Randomised Intervention Trial. Br J Nutr. 2014 Nov 14;112(9):1510-20. PubMed PMID: 25231730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium supplementation and bone mineral accretion in Chinese adolescents aged 12-14 years: a 12-month, dose-response, randomised intervention trial. AU - Ma,Xiao-ming, AU - Huang,Zhen-wu, AU - Yang,Xiao-guang, AU - Su,Yi-xiang, Y1 - 2014/09/18/ PY - 2014/9/19/entrez PY - 2014/9/19/pubmed PY - 2015/2/24/medline SP - 1510 EP - 20 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 112 IS - 9 N2 - A 12-month, dose-response, randomised, intervention trial was conducted to determine adequate Ca intake levels for Chinese adolescents by investigating the effect of Ca supplementation on bone mineral accretion. A total of 220 Han adolescents (111 girls and 109 boys) aged 12-14 years were recruited. All subjects were randomly divided into three groups. The bone mineral content (BMC) and bone mineral density (BMD) of the whole body, lumbar spine (L1-L4), left hip and femoral neck were measured by dual-energy X-ray absorptiometry. Girls in the high-Ca group (actual Ca intake: 1243 (sd 193) mg/d) exhibited greater increases in the femoral neck BMC compared with those in the low-Ca group (9·7 v. 6·4 %, P =0·04) over the 1-year intervention period. The increases in femoral neck BMC were greater in boys in the high-Ca and medium-Ca groups (actual Ca intake: 985 (sd 168) mg/d) than in those in the low-Ca group (15·7 v. 11·7 %, P =0·03; 15·8 v. 11·7 %, P =0·03). Ca supplementation had significant effects on the whole-body BMC and BMD in subjects with physical activity levels>34·86 metabolic equivalents and on the spine BMD and BMC and BMD of most sites in subjects with Tanner stage < 3. Increasing Ca intake levels with Ca supplementation enhanced femoral neck mineral acquisition in Chinese adolescents. Furthermore, high physical activity levels and low Tanner stage appeared to significantly contribute to the effect of Ca supplementation on bone mass. Whether this is a lasting beneficial effect leading to the optimisation of peak bone mass needs to be determined in other long-term prospective studies. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25231730/Calcium_supplementation_and_bone_mineral_accretion_in_Chinese_adolescents_aged_12_14_years:_a_12_month_dose_response_randomised_intervention_trial_ L2 - https://www.cambridge.org/core/product/identifier/S0007114514002384/type/journal_article DB - PRIME DP - Unbound Medicine ER -