TY - JOUR T1 - Electrical measurement of the hydration state of the skin surface in vivo. A1 - Tagami,H, PY - 2014/06/11/accepted PY - 2014/9/20/entrez PY - 2014/9/23/pubmed PY - 2015/6/5/medline SP - 29 EP - 33 JF - The British journal of dermatology JO - Br J Dermatol VL - 171 Suppl 3 N2 - Healthy skin surface is smooth and soft, because it is covered by the properly hydrated stratum corneum (SC), an extremely thin and soft barrier membrane produced by the underlying normal epidermis. By contrast, the skin surfaces covering pathological lesions exhibit dry and scaly changes and the SC shows poor barrier function. The SC barrier function has been assessed in vivo by instrumentally measuring transepidermal water loss (TEWL). However, there was a lack of any appropriate method for evaluating the hydration state of the skin surface in vivo until 1980 when we reported the feasibility of employing high-frequency conductance or capacitance to evaluate it quickly and accurately. With such measurements, we can assess easily the moisturizing efficacy of various topical agents in vivo as well as the distribution pattern of water in the SC by combining it with a serial tape-stripping procedure of the skin surface. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/25234175/Electrical_measurement_of_the_hydration_state_of_the_skin_surface_in_vivo_ L2 - https://doi.org/10.1111/bjd.13245 DB - PRIME DP - Unbound Medicine ER -