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EEG Neurofeedback therapy: Can it attenuate brain changes in TBI?
NeuroRehabilitation 2014; 35(3):481-4N

Abstract

BACKGROUND

Electroencephalogram Neurofeedback therapy (EEG-NFT) has several potential beneficial effects in terms of improving cognition and electrophysiological regulation among patients with brain injury. However, in vivo structural and functional changes remain less explored.

OBJECTIVE

The aim of the present study is to explore EEG-NFT induced in vivo changes in traumatic brain injury (TBI) patients.

METHOD

Two patients with mean age of 15 years with moderate head injury who had more than seven post concussion symptoms and poor cognitive performances (<5 percentile) were subjected to 20 sessions of EEG-NFT. The neuropsychological test scores, post concussion symptoms and MRI scan of the brain were recorded pre-post to EEG-NFT.

RESULTS

During EEG-NFT the cognitive scores and concussion symptoms improved significantly (p < 0.05). The EEG-NFT has shown significant increase in cortical grey matter (GM) volumes (p < 0.0001) and fractional anisotropy (FA) of cortical white matter (WM) tracts (p < 0.0001, voxel max 60 and above). There was a significant decrease in global, local efficiency, cost and clustering coefficient of functional connectivity (Wilcoxon Sign Rank Test p < 0.05). Interestingly there was a significant increase in thalamo-cortical connection (increase FA value) after EEG-NFT.

CONCLUSION

The EEG-NFT therapy has shown significant changes in structural and functional connectivity among young moderately injured TBI patients.

Authors+Show Affiliations

Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.Department of Clinical Psychology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.Department of Clinical Psychology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25238859

Citation

Munivenkatappa, Ashok, et al. "EEG Neurofeedback Therapy: Can It Attenuate Brain Changes in TBI?" NeuroRehabilitation, vol. 35, no. 3, 2014, pp. 481-4.
Munivenkatappa A, Rajeswaran J, Indira Devi B, et al. EEG Neurofeedback therapy: Can it attenuate brain changes in TBI? NeuroRehabilitation. 2014;35(3):481-4.
Munivenkatappa, A., Rajeswaran, J., Indira Devi, B., Bennet, N., & Upadhyay, N. (2014). EEG Neurofeedback therapy: Can it attenuate brain changes in TBI? NeuroRehabilitation, 35(3), pp. 481-4. doi:10.3233/NRE-141140.
Munivenkatappa A, et al. EEG Neurofeedback Therapy: Can It Attenuate Brain Changes in TBI. NeuroRehabilitation. 2014;35(3):481-4. PubMed PMID: 25238859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - EEG Neurofeedback therapy: Can it attenuate brain changes in TBI? AU - Munivenkatappa,Ashok, AU - Rajeswaran,Jamuna, AU - Indira Devi,Bhagavatula, AU - Bennet,Niranjana, AU - Upadhyay,Neeraj, PY - 2014/9/21/entrez PY - 2014/9/23/pubmed PY - 2015/6/27/medline KW - EEG-NFT KW - MRI scan KW - TBI KW - in vivo changes KW - neuropsychological scores SP - 481 EP - 4 JF - NeuroRehabilitation JO - NeuroRehabilitation VL - 35 IS - 3 N2 - BACKGROUND: Electroencephalogram Neurofeedback therapy (EEG-NFT) has several potential beneficial effects in terms of improving cognition and electrophysiological regulation among patients with brain injury. However, in vivo structural and functional changes remain less explored. OBJECTIVE: The aim of the present study is to explore EEG-NFT induced in vivo changes in traumatic brain injury (TBI) patients. METHOD: Two patients with mean age of 15 years with moderate head injury who had more than seven post concussion symptoms and poor cognitive performances (<5 percentile) were subjected to 20 sessions of EEG-NFT. The neuropsychological test scores, post concussion symptoms and MRI scan of the brain were recorded pre-post to EEG-NFT. RESULTS: During EEG-NFT the cognitive scores and concussion symptoms improved significantly (p < 0.05). The EEG-NFT has shown significant increase in cortical grey matter (GM) volumes (p < 0.0001) and fractional anisotropy (FA) of cortical white matter (WM) tracts (p < 0.0001, voxel max 60 and above). There was a significant decrease in global, local efficiency, cost and clustering coefficient of functional connectivity (Wilcoxon Sign Rank Test p < 0.05). Interestingly there was a significant increase in thalamo-cortical connection (increase FA value) after EEG-NFT. CONCLUSION: The EEG-NFT therapy has shown significant changes in structural and functional connectivity among young moderately injured TBI patients. SN - 1878-6448 UR - https://www.unboundmedicine.com/medline/citation/25238859/EEG_Neurofeedback_therapy:_Can_it_attenuate_brain_changes_in_TBI L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/NRE-141140 DB - PRIME DP - Unbound Medicine ER -