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Nut consumption has favorable effects on lipid profiles of Korean women with metabolic syndrome.
Nutr Res. 2014 Sep; 34(9):814-20.NR

Abstract

Nut consumption has been studied for its cardioprotective effects. However, the findings of clinical intervention studies are inconsistent; and no intervention studies have been conducted in the Korean population. We hypothesized that nut supplementation may have favorable influence on metabolic markers. Therefore, this study aimed to investigate the effects of nut consumption on metabolic parameters and biomarkers related to inflammation, oxidative stress, and endothelial function in Korean adults with metabolic syndrome. To this end, we designed a randomized, parallel, controlled dietary intervention study (ClinicalTrials.gov NCT02023749). Subjects with metabolic syndrome and a body mass index of at least 23 kg/m(2) were randomized to the Control group and the Nut group, which received supplementation with 30 g/d of mixed nuts (walnuts, peanuts, and pine nuts) for 6 weeks. Sixty volunteers were included in the final analysis. Metabolic markers were evaluated at baseline and at the end of the study. Total cholesterol and non-high-density lipoprotein cholesterol levels significantly improved in the Nut group compared to those in the Control group (P = .023 and P = .016, respectively) in women. Biomarkers related to inflammation, oxidative stress, and endothelial function did not significantly change from baseline in either group. Thus, supplementing a usual diet with mixed nuts for 6 weeks had favorable effects on several lipid parameters in Korean women with metabolic syndrome. These findings present a possible mechanism for the cardioprotective effects of nut consumption.

Authors+Show Affiliations

Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.Department of Family Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea. Electronic address: namgaaa@hanmail.net.Department of Endocrinology and Metabolism, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea.Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.Department of Endocrinology and Metabolism, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea.Department of Family Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea.Department of Endocrinology and Metabolism, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea. Electronic address: nhkendo@gmail.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25238912

Citation

Lee, Young Joo, et al. "Nut Consumption Has Favorable Effects On Lipid Profiles of Korean Women With Metabolic Syndrome." Nutrition Research (New York, N.Y.), vol. 34, no. 9, 2014, pp. 814-20.
Lee YJ, Nam GE, Seo JA, et al. Nut consumption has favorable effects on lipid profiles of Korean women with metabolic syndrome. Nutr Res. 2014;34(9):814-20.
Lee, Y. J., Nam, G. E., Seo, J. A., Yoon, T., Seo, I., Lee, J. H., Im, D., Bahn, K. N., Jeong, S. A., Kang, T. S., Ahn, J. H., Kim, D. H., & Kim, N. H. (2014). Nut consumption has favorable effects on lipid profiles of Korean women with metabolic syndrome. Nutrition Research (New York, N.Y.), 34(9), 814-20. https://doi.org/10.1016/j.nutres.2014.08.011
Lee YJ, et al. Nut Consumption Has Favorable Effects On Lipid Profiles of Korean Women With Metabolic Syndrome. Nutr Res. 2014;34(9):814-20. PubMed PMID: 25238912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nut consumption has favorable effects on lipid profiles of Korean women with metabolic syndrome. AU - Lee,Young Joo, AU - Nam,Ga Eun, AU - Seo,Ji A, AU - Yoon,Taehyung, AU - Seo,Ilwon, AU - Lee,Jin Hee, AU - Im,Donggil, AU - Bahn,Kyeong-Nyeo, AU - Jeong,Si An, AU - Kang,Tae Seok, AU - Ahn,Jae Hee, AU - Kim,Do Hoon, AU - Kim,Nan Hee, Y1 - 2014/08/30/ PY - 2014/04/30/received PY - 2014/08/24/revised PY - 2014/08/26/accepted PY - 2014/9/21/entrez PY - 2014/9/23/pubmed PY - 2015/5/26/medline KW - Endothelial function KW - Inflammation KW - Lipid profile KW - Metabolic syndrome KW - Nuts KW - Oxidative stress SP - 814 EP - 20 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 34 IS - 9 N2 - Nut consumption has been studied for its cardioprotective effects. However, the findings of clinical intervention studies are inconsistent; and no intervention studies have been conducted in the Korean population. We hypothesized that nut supplementation may have favorable influence on metabolic markers. Therefore, this study aimed to investigate the effects of nut consumption on metabolic parameters and biomarkers related to inflammation, oxidative stress, and endothelial function in Korean adults with metabolic syndrome. To this end, we designed a randomized, parallel, controlled dietary intervention study (ClinicalTrials.gov NCT02023749). Subjects with metabolic syndrome and a body mass index of at least 23 kg/m(2) were randomized to the Control group and the Nut group, which received supplementation with 30 g/d of mixed nuts (walnuts, peanuts, and pine nuts) for 6 weeks. Sixty volunteers were included in the final analysis. Metabolic markers were evaluated at baseline and at the end of the study. Total cholesterol and non-high-density lipoprotein cholesterol levels significantly improved in the Nut group compared to those in the Control group (P = .023 and P = .016, respectively) in women. Biomarkers related to inflammation, oxidative stress, and endothelial function did not significantly change from baseline in either group. Thus, supplementing a usual diet with mixed nuts for 6 weeks had favorable effects on several lipid parameters in Korean women with metabolic syndrome. These findings present a possible mechanism for the cardioprotective effects of nut consumption. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/25238912/Nut_consumption_has_favorable_effects_on_lipid_profiles_of_Korean_women_with_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(14)00160-2 DB - PRIME DP - Unbound Medicine ER -