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The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling.

Abstract

Lipid derived mediators contribute to inflammation and the sensing of pain. The contributions of omega-6 derived prostanoids in enhancing inflammation and pain sensation are well known. Less well explored are the opposing anti-inflammatory and analgesic effects of the omega-6 derived epoxyeicosatrienoic acids. Far less has been described about the epoxidized metabolites derived from omega-3 long chain fatty acids. The epoxide metabolites are turned over rapidly with enzymatic hydrolysis by the soluble epoxide hydrolase being the major elimination pathway. Despite this, the overall understanding of the role of lipid mediators in the pathology of chronic pain is growing. Here, we review the role of long chain fatty acids and their metabolites in alleviating both acute and chronic pain conditions. We focus specifically on the epoxidized metabolites of omega-6 and omega-3 long chain fatty acids as well as a novel strategy to modulate their activity in vivo.

Authors+Show Affiliations

Department of Entomology and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, United States.Department of Entomology and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, United States.Department of Entomology and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, United States.Department of Entomology and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, United States. Electronic address: bdhammock@ucdavis.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25240260

Citation

Wagner, Karen, et al. "The Role of Long Chain Fatty Acids and Their Epoxide Metabolites in Nociceptive Signaling." Prostaglandins & Other Lipid Mediators, vol. 113-115, 2014, pp. 2-12.
Wagner K, Vito S, Inceoglu B, et al. The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins Other Lipid Mediat. 2014;113-115:2-12.
Wagner, K., Vito, S., Inceoglu, B., & Hammock, B. D. (2014). The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins & Other Lipid Mediators, 113-115, pp. 2-12. doi:10.1016/j.prostaglandins.2014.09.001.
Wagner K, et al. The Role of Long Chain Fatty Acids and Their Epoxide Metabolites in Nociceptive Signaling. Prostaglandins Other Lipid Mediat. 2014;113-115:2-12. PubMed PMID: 25240260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. AU - Wagner,Karen, AU - Vito,Steve, AU - Inceoglu,Bora, AU - Hammock,Bruce D, Y1 - 2014/09/18/ PY - 2014/07/10/received PY - 2014/08/27/revised PY - 2014/09/03/accepted PY - 2014/9/22/entrez PY - 2014/9/23/pubmed PY - 2015/8/19/medline KW - EpDPEs) KW - Epoxy fatty acids (EpFAs) KW - Epoxydocosapentanoic acids (EDP KW - Epoxyeicosatrienoic acids (EETs) KW - Omega-3 fatty acids KW - Pain KW - Soluble epoxide hydrolase (sEH) SP - 2 EP - 12 JF - Prostaglandins & other lipid mediators JO - Prostaglandins Other Lipid Mediat. VL - 113-115 N2 - Lipid derived mediators contribute to inflammation and the sensing of pain. The contributions of omega-6 derived prostanoids in enhancing inflammation and pain sensation are well known. Less well explored are the opposing anti-inflammatory and analgesic effects of the omega-6 derived epoxyeicosatrienoic acids. Far less has been described about the epoxidized metabolites derived from omega-3 long chain fatty acids. The epoxide metabolites are turned over rapidly with enzymatic hydrolysis by the soluble epoxide hydrolase being the major elimination pathway. Despite this, the overall understanding of the role of lipid mediators in the pathology of chronic pain is growing. Here, we review the role of long chain fatty acids and their metabolites in alleviating both acute and chronic pain conditions. We focus specifically on the epoxidized metabolites of omega-6 and omega-3 long chain fatty acids as well as a novel strategy to modulate their activity in vivo. SN - 1098-8823 UR - https://www.unboundmedicine.com/medline/citation/25240260/The_role_of_long_chain_fatty_acids_and_their_epoxide_metabolites_in_nociceptive_signaling_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1098-8823(14)00044-6 DB - PRIME DP - Unbound Medicine ER -