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PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease.
Surg Obes Relat Dis 2015 Jul-Aug; 11(4):888-94SO

Abstract

BACKGROUND

The patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 variant is associated with histologic disease severity in patients with nonalcoholic fatty liver disease (NAFLD); however, whether the PNPLA3 genotype has an effect on susceptibility of nonalcoholic steatohepatitis (NASH) from NAFLD among severely obese patients remains unclear. The objective of this study was to investigate the role of the PNPLA3 genotype on NASH in severely obese Asian patients with NAFLD.

METHODS

The PNPLA3 rs738409 genotype was determined in 181 severely obese patients who underwent bariatric surgery. The diagnosis of NASH and the NAFLD activity score (NAS) were determined by liver histopathology.

RESULTS

Of the 181 patients, 29 (16.0%), 60 (33.2%), and 92 (50.8%) were in the non-NAFLD, steatosis, and NASH groups, respectively. The PNPLA3 rs738409 GG genotype was associated with higher liver enzymes and a higher risk for NASH (odds ratio [OR], 3.72; 95% CI, 1.25-11.05). The GG genotype was also associated with histologic severity of NAFLD, including higher steatosis grade (OR, 9.94; 95% CI, 2.20-44.83 for patients with grade 3 steatosis) and NAS (OR, 11.49; 95% CI, 2.50-52.83 for patients with a NAS ≥5). Finally, multiple logistic regression also showed that the GG genotype was an independent risk factor for NASH (OR, 3.58; 95% CI, 1.15-11.12) in NAFLD patients.

CONCLUSION

The PNPLA3 rs738409 GG genotype increases susceptibility of NASH in severely obese Asians with NAFLD and correlates to histologic severity of NAFLD.

Authors+Show Affiliations

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; Bariatric and Metabolic International Surgery Center, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.Bariatric and Metabolic International Surgery Center, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.Department of Pathology, Lin Shin Hospital, Taichung, Taiwan.Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Hepatitis Center and Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: fish6069@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25240529

Citation

Tai, Chi-Ming, et al. "PNPLA3 Genotype Increases Susceptibility of Nonalcoholic Steatohepatitis Among Obese Patients With Nonalcoholic Fatty Liver Disease." Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery, vol. 11, no. 4, 2015, pp. 888-94.
Tai CM, Huang CK, Tu HP, et al. PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease. Surg Obes Relat Dis. 2015;11(4):888-94.
Tai, C. M., Huang, C. K., Tu, H. P., Hwang, J. C., Chang, C. Y., & Yu, M. L. (2015). PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease. Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery, 11(4), pp. 888-94. doi:10.1016/j.soard.2014.07.016.
Tai CM, et al. PNPLA3 Genotype Increases Susceptibility of Nonalcoholic Steatohepatitis Among Obese Patients With Nonalcoholic Fatty Liver Disease. Surg Obes Relat Dis. 2015;11(4):888-94. PubMed PMID: 25240529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease. AU - Tai,Chi-Ming, AU - Huang,Chih-Kun, AU - Tu,Hung-Pin, AU - Hwang,Jau-Chung, AU - Chang,Chi-Yang, AU - Yu,Ming-Lung, Y1 - 2014/08/01/ PY - 2014/05/09/received PY - 2014/07/07/revised PY - 2014/07/25/accepted PY - 2014/9/22/entrez PY - 2014/9/23/pubmed PY - 2016/5/4/medline KW - Bariatric surgery KW - Nonalcoholic fatty liver disease KW - Nonalcoholic steatohepatitis KW - Obesity KW - PNPLA3 SP - 888 EP - 94 JF - Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery JO - Surg Obes Relat Dis VL - 11 IS - 4 N2 - BACKGROUND: The patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 variant is associated with histologic disease severity in patients with nonalcoholic fatty liver disease (NAFLD); however, whether the PNPLA3 genotype has an effect on susceptibility of nonalcoholic steatohepatitis (NASH) from NAFLD among severely obese patients remains unclear. The objective of this study was to investigate the role of the PNPLA3 genotype on NASH in severely obese Asian patients with NAFLD. METHODS: The PNPLA3 rs738409 genotype was determined in 181 severely obese patients who underwent bariatric surgery. The diagnosis of NASH and the NAFLD activity score (NAS) were determined by liver histopathology. RESULTS: Of the 181 patients, 29 (16.0%), 60 (33.2%), and 92 (50.8%) were in the non-NAFLD, steatosis, and NASH groups, respectively. The PNPLA3 rs738409 GG genotype was associated with higher liver enzymes and a higher risk for NASH (odds ratio [OR], 3.72; 95% CI, 1.25-11.05). The GG genotype was also associated with histologic severity of NAFLD, including higher steatosis grade (OR, 9.94; 95% CI, 2.20-44.83 for patients with grade 3 steatosis) and NAS (OR, 11.49; 95% CI, 2.50-52.83 for patients with a NAS ≥5). Finally, multiple logistic regression also showed that the GG genotype was an independent risk factor for NASH (OR, 3.58; 95% CI, 1.15-11.12) in NAFLD patients. CONCLUSION: The PNPLA3 rs738409 GG genotype increases susceptibility of NASH in severely obese Asians with NAFLD and correlates to histologic severity of NAFLD. SN - 1878-7533 UR - https://www.unboundmedicine.com/medline/citation/25240529/PNPLA3_genotype_increases_susceptibility_of_nonalcoholic_steatohepatitis_among_obese_patients_with_nonalcoholic_fatty_liver_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1550-7289(14)00313-X DB - PRIME DP - Unbound Medicine ER -