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Meloxicam-loaded nanocapsules have antinociceptive and antiedematogenic effects in acute models of nociception.
Life Sci. 2014 Oct 12; 115(1-2):36-43.LS

Abstract

AIMS

The development of new treatments for inflammation and pain continues to be of high interest, since long-acting effect is critical for patients. The present study investigated whether the polymeric nanocapsules, a drug delivery system, have pharmacological effect on acute nociceptive and inflammatory models in mice.

MAIN METHODS

Swiss mice (20-25 g) were previously pre-treated with meloxicam-loaded nanocapsules (M-NC) or free meloxicam (M-F) or suspension without drug (B-NC), at a dose of 5 mg/kg (per oral) at different times (0.5-120 h). Antinociceptive and antiedematogenic effects were evaluated by chemical (acetic acid-induced abdominal writhing, nociception and paw edema induced by formalin and glutamate, croton oil-induced ear edema) and thermal (tail immersion and hot-plate) tests.

KEY FINDINGS

M-NC reduced the licking time- and paw edema-induced by glutamate and formalin, while M-F did not have an effect. In the acetic acid-induced abdominal writhing and croton oil-induced ear edema, analysis of time-course revealed that M-NC showed a response more prolonged than M-F. In the hot-plate test, a thermal test, the time-course analysis indicated a similar increase in the latency response to thermal stimuli of M-NC and M-F, while in the tail-immersion test M-F had an effect at 0.5 h and M-NC at 24 h.

SIGNIFICANCE

Polymeric nanoparticles had antinociceptive, anti-inflammatory and antiedematogenic effects in the formalin and glutamate tests, and prolonged the effect in acetic acid and croton oil tests, but not in thermal tests, supporting the idea that the inflammatory process in tissues facilitates the vectoring of polymeric nanoparticles.

Authors+Show Affiliations

Centro de Ciências Tecnológicas, Centro Universitário Franciscano, CEP 97010-032 Santa Maria, RS, Brazil.Centro de Ciências Tecnológicas, Centro Universitário Franciscano, CEP 97010-032 Santa Maria, RS, Brazil.Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas CEP 96010-900, RS, Brazil. Electronic address: ethelwilhelm@yahoo.com.br.Centro de Ciências Tecnológicas, Centro Universitário Franciscano, CEP 97010-032 Santa Maria, RS, Brazil.Centro de Ciências da Saúde, Universidade Federal de Santa Maria, CEP 97105-900 Santa Maria, RS, Brazil.Centro de Ciências Tecnológicas, Centro Universitário Franciscano, CEP 97010-032 Santa Maria, RS, Brazil; Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas CEP 96010-900, RS, Brazil. Electronic address: cristiane_luchese@yahoo.com.br.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25241126

Citation

Villalba, Benonio T., et al. "Meloxicam-loaded Nanocapsules Have Antinociceptive and Antiedematogenic Effects in Acute Models of Nociception." Life Sciences, vol. 115, no. 1-2, 2014, pp. 36-43.
Villalba BT, Ianiski FR, Wilhelm EA, et al. Meloxicam-loaded nanocapsules have antinociceptive and antiedematogenic effects in acute models of nociception. Life Sci. 2014;115(1-2):36-43.
Villalba, B. T., Ianiski, F. R., Wilhelm, E. A., Fernandes, R. S., Alves, M. P., & Luchese, C. (2014). Meloxicam-loaded nanocapsules have antinociceptive and antiedematogenic effects in acute models of nociception. Life Sciences, 115(1-2), 36-43. https://doi.org/10.1016/j.lfs.2014.09.002
Villalba BT, et al. Meloxicam-loaded Nanocapsules Have Antinociceptive and Antiedematogenic Effects in Acute Models of Nociception. Life Sci. 2014 Oct 12;115(1-2):36-43. PubMed PMID: 25241126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meloxicam-loaded nanocapsules have antinociceptive and antiedematogenic effects in acute models of nociception. AU - Villalba,Benonio T, AU - Ianiski,Francine R, AU - Wilhelm,Ethel A, AU - Fernandes,Renata S, AU - Alves,Marta P, AU - Luchese,Cristiane, Y1 - 2014/09/18/ PY - 2014/05/29/received PY - 2014/08/17/revised PY - 2014/09/05/accepted PY - 2014/9/22/entrez PY - 2014/9/23/pubmed PY - 2014/12/15/medline KW - Antiedematogenic KW - Antinociceptive KW - Meloxicam KW - Nanoparticles KW - Pain SP - 36 EP - 43 JF - Life sciences JO - Life Sci VL - 115 IS - 1-2 N2 - AIMS: The development of new treatments for inflammation and pain continues to be of high interest, since long-acting effect is critical for patients. The present study investigated whether the polymeric nanocapsules, a drug delivery system, have pharmacological effect on acute nociceptive and inflammatory models in mice. MAIN METHODS: Swiss mice (20-25 g) were previously pre-treated with meloxicam-loaded nanocapsules (M-NC) or free meloxicam (M-F) or suspension without drug (B-NC), at a dose of 5 mg/kg (per oral) at different times (0.5-120 h). Antinociceptive and antiedematogenic effects were evaluated by chemical (acetic acid-induced abdominal writhing, nociception and paw edema induced by formalin and glutamate, croton oil-induced ear edema) and thermal (tail immersion and hot-plate) tests. KEY FINDINGS: M-NC reduced the licking time- and paw edema-induced by glutamate and formalin, while M-F did not have an effect. In the acetic acid-induced abdominal writhing and croton oil-induced ear edema, analysis of time-course revealed that M-NC showed a response more prolonged than M-F. In the hot-plate test, a thermal test, the time-course analysis indicated a similar increase in the latency response to thermal stimuli of M-NC and M-F, while in the tail-immersion test M-F had an effect at 0.5 h and M-NC at 24 h. SIGNIFICANCE: Polymeric nanoparticles had antinociceptive, anti-inflammatory and antiedematogenic effects in the formalin and glutamate tests, and prolonged the effect in acetic acid and croton oil tests, but not in thermal tests, supporting the idea that the inflammatory process in tissues facilitates the vectoring of polymeric nanoparticles. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/25241126/Meloxicam_loaded_nanocapsules_have_antinociceptive_and_antiedematogenic_effects_in_acute_models_of_nociception_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(14)00751-6 DB - PRIME DP - Unbound Medicine ER -