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Differential association of frailty with cognitive decline and sarcopenia in community-dwelling older adults.
J Am Med Dir Assoc. 2015 Feb; 16(2):120-4.JA

Abstract

OBJECTIVES

Frailty in older adults is a serious problem because of various adverse health outcomes in many countries with aging populations, such as Japan. The purpose of this study was to determine whether frailty and pre-frailty are associated with cognitive decline and sarcopenia in community-dwelling older adults.

DESIGN

This is a cross-sectional study.

SETTING

Japan.

PARTICIPANTS

The participants were 273 Japanese community-dwelling older women aged 65 years and older.

MEASUREMENTS

We used the frailty criteria developed by the Cardiovascular Health Study to define physical frailty. We divided the cohort into nonfrail, prefrail, and frail according to frailty scores. Cognitive decline and memory decline were defined by using the Mini-Mental State Examination and Scenery Picture Memory Test, respectively. Sarcopenia was defined according to the diagnostic algorithm recommended by the Asian Working Group for Sarcopenia.

RESULTS

In the multivariate logistic regression analysis by using non-frail participants as the reference, pre-frail elderly individuals were significantly more likely to have sarcopenia than non-frail elderly individuals [odds ratio (OR): 2.77, 95% confidence interval (CI): 1.05-9.26], but not cognitive decline or memory decline. Frail elderly individuals were significantly more likely to have cognitive decline (OR: 5.76, 95% CI: 1.20-27.6), memory decline (OR: 5.53, 95% CI: 1.64-18.7) and sarcopenia (OR: 19.1, 95% CI: 3.73-98.0) than non-frail elderly individuals.

CONCLUSIONS

Sarcopenia was associated with pre-frailty and frailty, whereas cognitive decline was associated only with frailty.

Authors+Show Affiliations

Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Japan Society for the Promotion of Science, Tokyo, Japan. Electronic address: nishiguchi.shu.82s@st.kyoto-u.ac.jp.Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25244957

Citation

Nishiguchi, Shu, et al. "Differential Association of Frailty With Cognitive Decline and Sarcopenia in Community-dwelling Older Adults." Journal of the American Medical Directors Association, vol. 16, no. 2, 2015, pp. 120-4.
Nishiguchi S, Yamada M, Fukutani N, et al. Differential association of frailty with cognitive decline and sarcopenia in community-dwelling older adults. J Am Med Dir Assoc. 2015;16(2):120-4.
Nishiguchi, S., Yamada, M., Fukutani, N., Adachi, D., Tashiro, Y., Hotta, T., Morino, S., Shirooka, H., Nozaki, Y., Hirata, H., Yamaguchi, M., Arai, H., Tsuboyama, T., & Aoyama, T. (2015). Differential association of frailty with cognitive decline and sarcopenia in community-dwelling older adults. Journal of the American Medical Directors Association, 16(2), 120-4. https://doi.org/10.1016/j.jamda.2014.07.010
Nishiguchi S, et al. Differential Association of Frailty With Cognitive Decline and Sarcopenia in Community-dwelling Older Adults. J Am Med Dir Assoc. 2015;16(2):120-4. PubMed PMID: 25244957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential association of frailty with cognitive decline and sarcopenia in community-dwelling older adults. AU - Nishiguchi,Shu, AU - Yamada,Minoru, AU - Fukutani,Naoto, AU - Adachi,Daiki, AU - Tashiro,Yuto, AU - Hotta,Takayuki, AU - Morino,Saori, AU - Shirooka,Hidehiko, AU - Nozaki,Yuma, AU - Hirata,Hinako, AU - Yamaguchi,Moe, AU - Arai,Hidenori, AU - Tsuboyama,Tadao, AU - Aoyama,Tomoki, Y1 - 2014/09/20/ PY - 2014/07/15/received PY - 2014/07/22/accepted PY - 2014/9/24/entrez PY - 2014/9/24/pubmed PY - 2015/11/18/medline KW - Frailty KW - cognitive decline KW - community-dwelling older adults KW - sarcopenia SP - 120 EP - 4 JF - Journal of the American Medical Directors Association JO - J Am Med Dir Assoc VL - 16 IS - 2 N2 - OBJECTIVES: Frailty in older adults is a serious problem because of various adverse health outcomes in many countries with aging populations, such as Japan. The purpose of this study was to determine whether frailty and pre-frailty are associated with cognitive decline and sarcopenia in community-dwelling older adults. DESIGN: This is a cross-sectional study. SETTING: Japan. PARTICIPANTS: The participants were 273 Japanese community-dwelling older women aged 65 years and older. MEASUREMENTS: We used the frailty criteria developed by the Cardiovascular Health Study to define physical frailty. We divided the cohort into nonfrail, prefrail, and frail according to frailty scores. Cognitive decline and memory decline were defined by using the Mini-Mental State Examination and Scenery Picture Memory Test, respectively. Sarcopenia was defined according to the diagnostic algorithm recommended by the Asian Working Group for Sarcopenia. RESULTS: In the multivariate logistic regression analysis by using non-frail participants as the reference, pre-frail elderly individuals were significantly more likely to have sarcopenia than non-frail elderly individuals [odds ratio (OR): 2.77, 95% confidence interval (CI): 1.05-9.26], but not cognitive decline or memory decline. Frail elderly individuals were significantly more likely to have cognitive decline (OR: 5.76, 95% CI: 1.20-27.6), memory decline (OR: 5.53, 95% CI: 1.64-18.7) and sarcopenia (OR: 19.1, 95% CI: 3.73-98.0) than non-frail elderly individuals. CONCLUSIONS: Sarcopenia was associated with pre-frailty and frailty, whereas cognitive decline was associated only with frailty. SN - 1538-9375 UR - https://www.unboundmedicine.com/medline/citation/25244957/Differential_association_of_frailty_with_cognitive_decline_and_sarcopenia_in_community_dwelling_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-8610(14)00469-1 DB - PRIME DP - Unbound Medicine ER -