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Clinical implications of the hyperdynamic syndrome in cirrhosis.
Eur J Intern Med. 2014 Nov; 25(9):795-802.EJ

Abstract

The hyperdynamic syndrome is a late consequence of portal hypertension in cirrhosis. The principal hemodynamic manifestations of the hyperdynamic syndrome are high cardiac output, and increased heart rate and total blood volume, accompanied by reduced total systemic vascular resistance. Pathophysiology involves a complex of humoral and neural mechanisms that can determine hemodynamic changes, and lead to hyperdynamic circulation. In this review we focus our attention on the manifestations of the hyperdynamic syndrome. Some of these are well described and directly related to portal hypertension (varices, ascites, hepatic encephalopathy, and hepatorenal syndrome), while others, such as hepatopulmonary syndrome, portopulmonary hypertension, and cirrhotic cardiomyopathy, are less known as clinical manifestations related to cirrhosis and, therefore, merit further investigation.

Authors+Show Affiliations

Sezione di Gastroenterologia & Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, DIBIMIS, Università di Palermo, Palermo, Italy.Sezione di Gastroenterologia & Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, DIBIMIS, Università di Palermo, Palermo, Italy.Sezione di Gastroenterologia & Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, DIBIMIS, Università di Palermo, Palermo, Italy.Sezione di Gastroenterologia & Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, DIBIMIS, Università di Palermo, Palermo, Italy.Sezione di Gastroenterologia & Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, DIBIMIS, Università di Palermo, Palermo, Italy.Sezione di Gastroenterologia & Epatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, DIBIMIS, Università di Palermo, Palermo, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25245607

Citation

Licata, Anna, et al. "Clinical Implications of the Hyperdynamic Syndrome in Cirrhosis." European Journal of Internal Medicine, vol. 25, no. 9, 2014, pp. 795-802.
Licata A, Mazzola A, Ingrassia D, et al. Clinical implications of the hyperdynamic syndrome in cirrhosis. Eur J Intern Med. 2014;25(9):795-802.
Licata, A., Mazzola, A., Ingrassia, D., Calvaruso, V., Cammà, C., & Craxì, A. (2014). Clinical implications of the hyperdynamic syndrome in cirrhosis. European Journal of Internal Medicine, 25(9), 795-802. https://doi.org/10.1016/j.ejim.2014.09.004
Licata A, et al. Clinical Implications of the Hyperdynamic Syndrome in Cirrhosis. Eur J Intern Med. 2014;25(9):795-802. PubMed PMID: 25245607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical implications of the hyperdynamic syndrome in cirrhosis. AU - Licata,Anna, AU - Mazzola,Alessandra, AU - Ingrassia,Daniela, AU - Calvaruso,Vincenza, AU - Cammà,Calogero, AU - Craxì,Antonio, Y1 - 2014/09/20/ PY - 2014/05/07/received PY - 2014/09/02/revised PY - 2014/09/04/accepted PY - 2014/9/24/entrez PY - 2014/9/24/pubmed PY - 2015/7/25/medline KW - Ascites KW - CC KW - Cirrhosis KW - HPS KW - HRS KW - Hyperdynamic syndrome SP - 795 EP - 802 JF - European journal of internal medicine JO - Eur J Intern Med VL - 25 IS - 9 N2 - The hyperdynamic syndrome is a late consequence of portal hypertension in cirrhosis. The principal hemodynamic manifestations of the hyperdynamic syndrome are high cardiac output, and increased heart rate and total blood volume, accompanied by reduced total systemic vascular resistance. Pathophysiology involves a complex of humoral and neural mechanisms that can determine hemodynamic changes, and lead to hyperdynamic circulation. In this review we focus our attention on the manifestations of the hyperdynamic syndrome. Some of these are well described and directly related to portal hypertension (varices, ascites, hepatic encephalopathy, and hepatorenal syndrome), while others, such as hepatopulmonary syndrome, portopulmonary hypertension, and cirrhotic cardiomyopathy, are less known as clinical manifestations related to cirrhosis and, therefore, merit further investigation. SN - 1879-0828 UR - https://www.unboundmedicine.com/medline/citation/25245607/Clinical_implications_of_the_hyperdynamic_syndrome_in_cirrhosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0953-6205(14)00249-0 DB - PRIME DP - Unbound Medicine ER -