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Inverse association between coffee consumption and risk of cholecystectomy in women but not in men.
Clin Gastroenterol Hepatol. 2015 Jun; 13(6):1096-1102.e1.CG

Abstract

BACKGROUND & AIMS

There is conflicting epidemiologic evidence on whether coffee consumption reduces the risk of gallstone disease. We examined the association between coffee consumption and risk of cholecystectomy (as a proxy for symptomatic gallstone disease) in a prospective cohort study.

METHODS

We collected data from 30,989 women (born 1914-1948) and 40,936 men (born 1918-1952) from the Swedish Mammography Cohort and the Cohort of Swedish Men. Baseline information on coffee consumption was collected by using a food-frequency questionnaire; subjects were followed up for procedures of cholecystectomy from 1998 through 2011 by linkage to the Swedish Patient Register. Hazard ratios (HRs) were estimated by using Cox proportional hazard models.

RESULTS

During a total follow-up period of 905,933 person-years, we identified 1057 women and 962 men who had undergone a cholecystectomy. After adjustment for potential confounders, the HR of cholecystectomy was 0.58 (95% confidence interval [CI], 0.44-0.78) for women who drank ≥6 cups of coffee/day compared with women who drank <2 cups/day. In contrast, there was no association in men (HR, 0.96; 95% CI, 0.75-1.24). Because of this sex difference, we examined and found evidence of effect modification by menopausal status and use of hormone replacement therapy (HRT) (Pinteraction = .026). An inverse association was observed only in women who were premenopausal (HR, 0.17; 95% CI, 0.05-0.55) or used HRT (HR, 0.44; 95% CI, 0.28-0.70).

CONCLUSIONS

We observed an inverse association between coffee consumption and risk of cholecystectomy in women who were premenopausal or used HRT but not in other women or in men.

Authors+Show Affiliations

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Electronic address: caroline.nordenvall@ki.se.Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25245628

Citation

Nordenvall, Caroline, et al. "Inverse Association Between Coffee Consumption and Risk of Cholecystectomy in Women but Not in Men." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 13, no. 6, 2015, pp. 1096-1102.e1.
Nordenvall C, Oskarsson V, Wolk A. Inverse association between coffee consumption and risk of cholecystectomy in women but not in men. Clin Gastroenterol Hepatol. 2015;13(6):1096-1102.e1.
Nordenvall, C., Oskarsson, V., & Wolk, A. (2015). Inverse association between coffee consumption and risk of cholecystectomy in women but not in men. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 13(6), 1096-e1. https://doi.org/10.1016/j.cgh.2014.09.029
Nordenvall C, Oskarsson V, Wolk A. Inverse Association Between Coffee Consumption and Risk of Cholecystectomy in Women but Not in Men. Clin Gastroenterol Hepatol. 2015;13(6):1096-1102.e1. PubMed PMID: 25245628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inverse association between coffee consumption and risk of cholecystectomy in women but not in men. AU - Nordenvall,Caroline, AU - Oskarsson,Viktor, AU - Wolk,Alicja, Y1 - 2014/09/19/ PY - 2014/07/11/received PY - 2014/08/31/revised PY - 2014/09/03/accepted PY - 2014/9/24/entrez PY - 2014/9/24/pubmed PY - 2016/2/10/medline KW - Diet KW - Gallbladder KW - Surgery KW - Sweden SP - 1096 EP - 1102.e1 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin Gastroenterol Hepatol VL - 13 IS - 6 N2 - BACKGROUND & AIMS: There is conflicting epidemiologic evidence on whether coffee consumption reduces the risk of gallstone disease. We examined the association between coffee consumption and risk of cholecystectomy (as a proxy for symptomatic gallstone disease) in a prospective cohort study. METHODS: We collected data from 30,989 women (born 1914-1948) and 40,936 men (born 1918-1952) from the Swedish Mammography Cohort and the Cohort of Swedish Men. Baseline information on coffee consumption was collected by using a food-frequency questionnaire; subjects were followed up for procedures of cholecystectomy from 1998 through 2011 by linkage to the Swedish Patient Register. Hazard ratios (HRs) were estimated by using Cox proportional hazard models. RESULTS: During a total follow-up period of 905,933 person-years, we identified 1057 women and 962 men who had undergone a cholecystectomy. After adjustment for potential confounders, the HR of cholecystectomy was 0.58 (95% confidence interval [CI], 0.44-0.78) for women who drank ≥6 cups of coffee/day compared with women who drank <2 cups/day. In contrast, there was no association in men (HR, 0.96; 95% CI, 0.75-1.24). Because of this sex difference, we examined and found evidence of effect modification by menopausal status and use of hormone replacement therapy (HRT) (Pinteraction = .026). An inverse association was observed only in women who were premenopausal (HR, 0.17; 95% CI, 0.05-0.55) or used HRT (HR, 0.44; 95% CI, 0.28-0.70). CONCLUSIONS: We observed an inverse association between coffee consumption and risk of cholecystectomy in women who were premenopausal or used HRT but not in other women or in men. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/25245628/Inverse_association_between_coffee_consumption_and_risk_of_cholecystectomy_in_women_but_not_in_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(14)01348-2 DB - PRIME DP - Unbound Medicine ER -