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Unfavorable inflammatory profile in adults at risk of type 2 diabetes identified by hemoglobin A1c levels according to the American Diabetes Association criteria.
Acta Diabetol. 2015 Apr; 52(2):349-56.AD

Abstract

AIMS

We aimed to evaluate the inflammatory profile of individuals with prediabetes defined by HbA1c levels, according to the new American Diabetes Association criteria, and to determine the ability of HbA1c to identify individuals with subclinical inflammation independently of the contribution of other metabolic parameters such as fasting, 1- or 2-h post-load glucose (PG) levels.

METHODS

High sensitivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), fibrinogen, white blood cells (WBC) count and complement C3 (C3) were assessed, and oral glucose tolerance test (OGTT) was performed in 711 adults.

RESULTS

Subjects were stratified into three groups according to their HbA1c levels. Poor agreement existed between HbA1c and 2-h PG criteria for identification of individuals with prediabetes (κ coefficient = 0.300). As compared with subjects having HbA1c <5.7 % (39 mmol/mol), individuals with prediabetes (HbA1c 5.7-6.4 %, [39-46 mmol/mol]) exhibited a significant increase of the concentration of five inflammatory markers (hsCRP, ESR, fibrinogen, WBC count, C3) as well as of a cluster of inflammatory markers, as measured by an inflammatory score after adjusting for sex, age, smoking, fasting, 1- and 2-h PG levels. In multiple regression models including sex, age, body mass index, smoking habit, fasting, 1- and 2-h PG levels, and HOMA index, HbA1c levels were significant independent contributors to each of the five inflammatory markers examined.

CONCLUSIONS

These data suggest that HbA1c is a reliable marker of glucose homeostasis, and may identify individuals at increased risk of diabetes with unfavorable inflammatory profile independently from fasting and 2-h PG levels.

Authors+Show Affiliations

Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Study
Journal Article

Language

eng

PubMed ID

25246028

Citation

Fiorentino, T V., et al. "Unfavorable Inflammatory Profile in Adults at Risk of Type 2 Diabetes Identified By Hemoglobin A1c Levels According to the American Diabetes Association Criteria." Acta Diabetologica, vol. 52, no. 2, 2015, pp. 349-56.
Fiorentino TV, Hribal ML, Perticone M, et al. Unfavorable inflammatory profile in adults at risk of type 2 diabetes identified by hemoglobin A1c levels according to the American Diabetes Association criteria. Acta Diabetol. 2015;52(2):349-56.
Fiorentino, T. V., Hribal, M. L., Perticone, M., Andreozzi, F., Sciacqua, A., Perticone, F., & Sesti, G. (2015). Unfavorable inflammatory profile in adults at risk of type 2 diabetes identified by hemoglobin A1c levels according to the American Diabetes Association criteria. Acta Diabetologica, 52(2), 349-56. https://doi.org/10.1007/s00592-014-0647-2
Fiorentino TV, et al. Unfavorable Inflammatory Profile in Adults at Risk of Type 2 Diabetes Identified By Hemoglobin A1c Levels According to the American Diabetes Association Criteria. Acta Diabetol. 2015;52(2):349-56. PubMed PMID: 25246028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unfavorable inflammatory profile in adults at risk of type 2 diabetes identified by hemoglobin A1c levels according to the American Diabetes Association criteria. AU - Fiorentino,T V, AU - Hribal,M L, AU - Perticone,M, AU - Andreozzi,F, AU - Sciacqua,A, AU - Perticone,F, AU - Sesti,G, Y1 - 2014/09/23/ PY - 2014/06/19/received PY - 2014/08/31/accepted PY - 2014/9/24/entrez PY - 2014/9/24/pubmed PY - 2016/1/23/medline SP - 349 EP - 56 JF - Acta diabetologica JO - Acta Diabetol VL - 52 IS - 2 N2 - AIMS: We aimed to evaluate the inflammatory profile of individuals with prediabetes defined by HbA1c levels, according to the new American Diabetes Association criteria, and to determine the ability of HbA1c to identify individuals with subclinical inflammation independently of the contribution of other metabolic parameters such as fasting, 1- or 2-h post-load glucose (PG) levels. METHODS: High sensitivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), fibrinogen, white blood cells (WBC) count and complement C3 (C3) were assessed, and oral glucose tolerance test (OGTT) was performed in 711 adults. RESULTS: Subjects were stratified into three groups according to their HbA1c levels. Poor agreement existed between HbA1c and 2-h PG criteria for identification of individuals with prediabetes (κ coefficient = 0.300). As compared with subjects having HbA1c <5.7 % (39 mmol/mol), individuals with prediabetes (HbA1c 5.7-6.4 %, [39-46 mmol/mol]) exhibited a significant increase of the concentration of five inflammatory markers (hsCRP, ESR, fibrinogen, WBC count, C3) as well as of a cluster of inflammatory markers, as measured by an inflammatory score after adjusting for sex, age, smoking, fasting, 1- and 2-h PG levels. In multiple regression models including sex, age, body mass index, smoking habit, fasting, 1- and 2-h PG levels, and HOMA index, HbA1c levels were significant independent contributors to each of the five inflammatory markers examined. CONCLUSIONS: These data suggest that HbA1c is a reliable marker of glucose homeostasis, and may identify individuals at increased risk of diabetes with unfavorable inflammatory profile independently from fasting and 2-h PG levels. SN - 1432-5233 UR - https://www.unboundmedicine.com/medline/citation/25246028/Unfavorable_inflammatory_profile_in_adults_at_risk_of_type_2_diabetes_identified_by_hemoglobin_A1c_levels_according_to_the_American_Diabetes_Association_criteria_ L2 - https://dx.doi.org/10.1007/s00592-014-0647-2 DB - PRIME DP - Unbound Medicine ER -