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Sarcopenia as a useful predictor for long-term mortality in cirrhotic patients with ascites.
J Korean Med Sci 2014; 29(9):1253-9JK

Abstract

This study aimed to assess and compare sarcopenia with other prognostic factors for predicting long-term mortality in cirrhotic patients with ascites. Clinical data of 65 among 89 patients with measurement of all parameters were consecutively collected. Sarcopenia was evaluated as right psoas muscle thickness measurement divided by height (PMTH) (mm/m). During a mean follow-up of 20 (range: 1-49) months, 19 (29.2%) of 65 patients died. The values of the area under the receiver operating characteristics curve (AUROC) of Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, MELD-Na, and PMTH for predicting 1-yr mortality were 0.777 (95% CI, 0.635-0.883), 0.769 (95% CI, 0.627-0.877), 0.800 (95% CI, 0.661-0.900), and 0.833 (95% CI, 0.699-0.924), whereas hepatic venous pressure gradient was not significant (AUROC, 0.695; 95% CI. 0.547-0.818, P=0.053). The differences between PMTH and other prognostic variables were not significant (all P>0.05). The best cut-off value of PMTH to predict long-term mortality was 14 mm/m. The mortality rates at 1-yr and 2-yr with PMTH>14 mm/m vs. PMTH≤14 mm/m were 2.6% and 15.2% vs. 41.6% and 66.8%, respectively (P<0.001). The mortality in cirrhotic patients with PMTH≤14 mm/m was higher than those with PMTH>14 mm/m (HR, 5.398; 95% CI, 2.111-13.800, P<0.001). In conclusion, sarcopenia, evaluated by PMTH, is an independent useful predictor for long-term mortality in cirrhotic patients with ascites.

Authors+Show Affiliations

Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University, Guri, Korea.Department of Radiology, Hanyang University Guri Hospital, Hanyang University, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University, Guri, Korea.Department of Radiology, Hanyang University Guri Hospital, Hanyang University, Guri, Korea.Department of Radiology, Hanyang University Guri Hospital, Hanyang University, Guri, Korea.Department of Radiology, Hanyang University Guri Hospital, Hanyang University, Guri, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25246744

Citation

Kim, Tae Yeob, et al. "Sarcopenia as a Useful Predictor for Long-term Mortality in Cirrhotic Patients With Ascites." Journal of Korean Medical Science, vol. 29, no. 9, 2014, pp. 1253-9.
Kim TY, Kim MY, Sohn JH, et al. Sarcopenia as a useful predictor for long-term mortality in cirrhotic patients with ascites. J Korean Med Sci. 2014;29(9):1253-9.
Kim, T. Y., Kim, M. Y., Sohn, J. H., Kim, S. M., Ryu, J. A., Lim, S., & Kim, Y. (2014). Sarcopenia as a useful predictor for long-term mortality in cirrhotic patients with ascites. Journal of Korean Medical Science, 29(9), pp. 1253-9. doi:10.3346/jkms.2014.29.9.1253.
Kim TY, et al. Sarcopenia as a Useful Predictor for Long-term Mortality in Cirrhotic Patients With Ascites. J Korean Med Sci. 2014;29(9):1253-9. PubMed PMID: 25246744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sarcopenia as a useful predictor for long-term mortality in cirrhotic patients with ascites. AU - Kim,Tae Yeob, AU - Kim,Min Yeong, AU - Sohn,Joo Hyun, AU - Kim,Sun Min, AU - Ryu,Jeong Ah, AU - Lim,Sanghyeok, AU - Kim,Youngsoo, Y1 - 2014/09/02/ PY - 2014/05/21/received PY - 2014/07/02/accepted PY - 2014/9/24/entrez PY - 2014/9/24/pubmed PY - 2015/5/27/medline KW - Ascites KW - Liver Cirrhosis KW - Prognosis KW - Psoas Muscle Thickness KW - Sarcopenia SP - 1253 EP - 9 JF - Journal of Korean medical science JO - J. Korean Med. Sci. VL - 29 IS - 9 N2 - This study aimed to assess and compare sarcopenia with other prognostic factors for predicting long-term mortality in cirrhotic patients with ascites. Clinical data of 65 among 89 patients with measurement of all parameters were consecutively collected. Sarcopenia was evaluated as right psoas muscle thickness measurement divided by height (PMTH) (mm/m). During a mean follow-up of 20 (range: 1-49) months, 19 (29.2%) of 65 patients died. The values of the area under the receiver operating characteristics curve (AUROC) of Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, MELD-Na, and PMTH for predicting 1-yr mortality were 0.777 (95% CI, 0.635-0.883), 0.769 (95% CI, 0.627-0.877), 0.800 (95% CI, 0.661-0.900), and 0.833 (95% CI, 0.699-0.924), whereas hepatic venous pressure gradient was not significant (AUROC, 0.695; 95% CI. 0.547-0.818, P=0.053). The differences between PMTH and other prognostic variables were not significant (all P>0.05). The best cut-off value of PMTH to predict long-term mortality was 14 mm/m. The mortality rates at 1-yr and 2-yr with PMTH>14 mm/m vs. PMTH≤14 mm/m were 2.6% and 15.2% vs. 41.6% and 66.8%, respectively (P<0.001). The mortality in cirrhotic patients with PMTH≤14 mm/m was higher than those with PMTH>14 mm/m (HR, 5.398; 95% CI, 2.111-13.800, P<0.001). In conclusion, sarcopenia, evaluated by PMTH, is an independent useful predictor for long-term mortality in cirrhotic patients with ascites. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/25246744/Sarcopenia_as_a_useful_predictor_for_long_term_mortality_in_cirrhotic_patients_with_ascites_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2014.29.9.1253 DB - PRIME DP - Unbound Medicine ER -