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Anthropometric factors and ovarian cancer risk: a systematic review and nonlinear dose-response meta-analysis of prospective studies.
Int J Cancer 2015; 136(8):1888-98IJ

Abstract

In the World Cancer Research Fund/American Institute for Cancer Research report from 2007 the evidence relating body fatness to ovarian cancer risk was considered inconclusive, while the evidence supported a probably causal relationship between adult attained height and increased risk. Several additional cohort studies have since been published, and therefore we conducted an updated meta-analysis of the evidence as part of the Continuous Update Project. We searched PubMed and several other databases up to 20th of August 2014. Summary relative risks (RRs) were calculated using a random effects model. The summary relative risk for a 5-U increment in BMI was 1.07 (95% CI: 1.03-1.11, I(2) = 54%, n = 28 studies). There was evidence of a nonlinear association, pnonlinearity < 0.0001, with risk increasing significantly from BMI∼28 and above. The summary RR per 5 U increase in BMI in early adulthood was 1.12 (95% CI: 1.05-1.20, I(2) = 0%, pheterogeneity = 0.54, n = 6), per 5 kg increase in body weight was 1.03 (95% CI: 1.02-1.05, I(2) = 0%, n = 4) and per 10 cm increase in waist circumference was 1.06 (95% CI: 1.00-1.12, I(2) = 0%, n = 6). No association was found for weight gain, hip circumference or waist-to-hip ratio. The summary RR per 10 cm increase in height was 1.16 (95% CI: 1.11-1.21, I(2) = 32%, n = 16). In conclusion, greater body fatness as measured by body mass index and weight are positively associated risk of ovarian cancer, and in addition, greater height is associated with increased risk. Further studies are needed to clarify whether abdominal fatness and weight gain is associated with risk.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health Imperial College London, London, United Kingdom; Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

25250505

Citation

Aune, Dagfinn, et al. "Anthropometric Factors and Ovarian Cancer Risk: a Systematic Review and Nonlinear Dose-response Meta-analysis of Prospective Studies." International Journal of Cancer, vol. 136, no. 8, 2015, pp. 1888-98.
Aune D, Navarro Rosenblatt DA, Chan DS, et al. Anthropometric factors and ovarian cancer risk: a systematic review and nonlinear dose-response meta-analysis of prospective studies. Int J Cancer. 2015;136(8):1888-98.
Aune, D., Navarro Rosenblatt, D. A., Chan, D. S., Abar, L., Vingeliene, S., Vieira, A. R., ... Norat, T. (2015). Anthropometric factors and ovarian cancer risk: a systematic review and nonlinear dose-response meta-analysis of prospective studies. International Journal of Cancer, 136(8), pp. 1888-98. doi:10.1002/ijc.29207.
Aune D, et al. Anthropometric Factors and Ovarian Cancer Risk: a Systematic Review and Nonlinear Dose-response Meta-analysis of Prospective Studies. Int J Cancer. 2015 Apr 15;136(8):1888-98. PubMed PMID: 25250505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric factors and ovarian cancer risk: a systematic review and nonlinear dose-response meta-analysis of prospective studies. AU - Aune,Dagfinn, AU - Navarro Rosenblatt,Deborah A, AU - Chan,Doris Sau Man, AU - Abar,Leila, AU - Vingeliene,Snieguole, AU - Vieira,Ana Rita, AU - Greenwood,Darren C, AU - Norat,Teresa, Y1 - 2014/09/24/ PY - 2014/04/11/received PY - 2014/08/13/revised PY - 2014/08/19/accepted PY - 2014/9/25/entrez PY - 2014/9/25/pubmed PY - 2015/4/17/medline KW - body mass index KW - height KW - meta-analysis KW - ovarian cancer KW - weight SP - 1888 EP - 98 JF - International journal of cancer JO - Int. J. Cancer VL - 136 IS - 8 N2 - In the World Cancer Research Fund/American Institute for Cancer Research report from 2007 the evidence relating body fatness to ovarian cancer risk was considered inconclusive, while the evidence supported a probably causal relationship between adult attained height and increased risk. Several additional cohort studies have since been published, and therefore we conducted an updated meta-analysis of the evidence as part of the Continuous Update Project. We searched PubMed and several other databases up to 20th of August 2014. Summary relative risks (RRs) were calculated using a random effects model. The summary relative risk for a 5-U increment in BMI was 1.07 (95% CI: 1.03-1.11, I(2) = 54%, n = 28 studies). There was evidence of a nonlinear association, pnonlinearity < 0.0001, with risk increasing significantly from BMI∼28 and above. The summary RR per 5 U increase in BMI in early adulthood was 1.12 (95% CI: 1.05-1.20, I(2) = 0%, pheterogeneity = 0.54, n = 6), per 5 kg increase in body weight was 1.03 (95% CI: 1.02-1.05, I(2) = 0%, n = 4) and per 10 cm increase in waist circumference was 1.06 (95% CI: 1.00-1.12, I(2) = 0%, n = 6). No association was found for weight gain, hip circumference or waist-to-hip ratio. The summary RR per 10 cm increase in height was 1.16 (95% CI: 1.11-1.21, I(2) = 32%, n = 16). In conclusion, greater body fatness as measured by body mass index and weight are positively associated risk of ovarian cancer, and in addition, greater height is associated with increased risk. Further studies are needed to clarify whether abdominal fatness and weight gain is associated with risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/25250505/Anthropometric_factors_and_ovarian_cancer_risk:_a_systematic_review_and_nonlinear_dose_response_meta_analysis_of_prospective_studies_ L2 - https://doi.org/10.1002/ijc.29207 DB - PRIME DP - Unbound Medicine ER -