Tags

Type your tag names separated by a space and hit enter

Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction.
J Appl Physiol (1985). 1989 Apr; 66(4):1685-93.JA

Abstract

In this study we investigated the effect of the selective and potent thromboxane A2 (TxA2) receptor antagonist GR32191 on smooth muscle contraction induced by the TxA2 analogue U46619, prostaglandin (PG) D2, PGF2 alpha, and methacholine (MCh) in guinea pig airways in vitro and the airways response provoked by inhaled PGD2 and MCh in asthmatic subjects in vivo. GR32191 antagonized competitively the contractile responses of all three prostanoids to a similar degree but had no effect on MCh-induced contractions. In asthmatic subjects GR32191, in a single oral dose of 80 mg, did not affect base-line airway caliber or MCh-induced broncho-constriction but caused significant inhibition of PGD2-induced bronchoconstriction, displacing the concentration-response curves to the right by greater than 10-fold. The effect of the same oral dose of GR32191 on allergen-induced immediate bronchoconstriction was subsequently investigated in allergic asthmatic subjects. In individual subjects, GR32191 inhibited to varying degrees the overall bronchoconstrictor response, with the maximum effect occurring between 10 and 30 min after allergen challenge. These studies suggest that prostanoids contribute to the immediate bronchoconstriction induced by inhaled allergen in allergic asthmatics, and that this effect is mediated by stimulation of a thromboxane receptor.

Authors+Show Affiliations

Immunopharmacology Group, Southampton General Hospital, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2525122

Citation

Beasley, R C., et al. "Effect of a Thromboxane Receptor Antagonist On PGD2- and Allergen-induced Bronchoconstriction." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 66, no. 4, 1989, pp. 1685-93.
Beasley RC, Featherstone RL, Church MK, et al. Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. J Appl Physiol (1985). 1989;66(4):1685-93.
Beasley, R. C., Featherstone, R. L., Church, M. K., Rafferty, P., Varley, J. G., Harris, A., Robinson, C., & Holgate, S. T. (1989). Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. Journal of Applied Physiology (Bethesda, Md. : 1985), 66(4), 1685-93.
Beasley RC, et al. Effect of a Thromboxane Receptor Antagonist On PGD2- and Allergen-induced Bronchoconstriction. J Appl Physiol (1985). 1989;66(4):1685-93. PubMed PMID: 2525122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. AU - Beasley,R C, AU - Featherstone,R L, AU - Church,M K, AU - Rafferty,P, AU - Varley,J G, AU - Harris,A, AU - Robinson,C, AU - Holgate,S T, PY - 1989/4/1/pubmed PY - 1989/4/1/medline PY - 1989/4/1/entrez SP - 1685 EP - 93 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 66 IS - 4 N2 - In this study we investigated the effect of the selective and potent thromboxane A2 (TxA2) receptor antagonist GR32191 on smooth muscle contraction induced by the TxA2 analogue U46619, prostaglandin (PG) D2, PGF2 alpha, and methacholine (MCh) in guinea pig airways in vitro and the airways response provoked by inhaled PGD2 and MCh in asthmatic subjects in vivo. GR32191 antagonized competitively the contractile responses of all three prostanoids to a similar degree but had no effect on MCh-induced contractions. In asthmatic subjects GR32191, in a single oral dose of 80 mg, did not affect base-line airway caliber or MCh-induced broncho-constriction but caused significant inhibition of PGD2-induced bronchoconstriction, displacing the concentration-response curves to the right by greater than 10-fold. The effect of the same oral dose of GR32191 on allergen-induced immediate bronchoconstriction was subsequently investigated in allergic asthmatic subjects. In individual subjects, GR32191 inhibited to varying degrees the overall bronchoconstrictor response, with the maximum effect occurring between 10 and 30 min after allergen challenge. These studies suggest that prostanoids contribute to the immediate bronchoconstriction induced by inhaled allergen in allergic asthmatics, and that this effect is mediated by stimulation of a thromboxane receptor. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/2525122/Effect_of_a_thromboxane_receptor_antagonist_on_PGD2__and_allergen_induced_bronchoconstriction_ L2 - https://journals.physiology.org/doi/10.1152/jappl.1989.66.4.1685?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -