Tags

Type your tag names separated by a space and hit enter

Ruthenium(II)-catalyzed direct addition of indole/pyrrole C2-H bonds to alkynes.
J Org Chem. 2014 Oct 17; 79(20):9472-80.JO

Abstract

A ruthenium-catalyzed C2-hydroindolation of alkynes has been achieved. This protocol provides a rapid and concise access to kinds of 2-alkenyl-substituted N-(2-pyridyl)indoles in which the pyridyl moiety can be easily removed to afford free (N-H) indoles under mild conditions. Various arenes and alkynes, including electron-deficient and electron-rich internal alkynes and terminal alkynes, allow for this transformation.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Liang L
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510641, China.
Fu S
No affiliation info available
Lin D
No affiliation info available
Zhang XQ
No affiliation info available
Deng Y
No affiliation info available
Jiang H
No affiliation info available
Zeng W
No affiliation info available

MeSH

AlkynesCatalysisHydrogen BondingIndolesMolecular StructurePyrrolesRuthenium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25251735

Citation

Liang, Libo, et al. "Ruthenium(II)-catalyzed Direct Addition of Indole/pyrrole C2-H Bonds to Alkynes." The Journal of Organic Chemistry, vol. 79, no. 20, 2014, pp. 9472-80.
Liang L, Fu S, Lin D, et al. Ruthenium(II)-catalyzed direct addition of indole/pyrrole C2-H bonds to alkynes. J Org Chem. 2014;79(20):9472-80.
Liang, L., Fu, S., Lin, D., Zhang, X. Q., Deng, Y., Jiang, H., & Zeng, W. (2014). Ruthenium(II)-catalyzed direct addition of indole/pyrrole C2-H bonds to alkynes. The Journal of Organic Chemistry, 79(20), 9472-80. https://doi.org/10.1021/jo501460h
Liang L, et al. Ruthenium(II)-catalyzed Direct Addition of Indole/pyrrole C2-H Bonds to Alkynes. J Org Chem. 2014 Oct 17;79(20):9472-80. PubMed PMID: 25251735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ruthenium(II)-catalyzed direct addition of indole/pyrrole C2-H bonds to alkynes. AU - Liang,Libo, AU - Fu,Shaomin, AU - Lin,Dongen, AU - Zhang,Xiao-Qi, AU - Deng,Yuanfu, AU - Jiang,Huanfeng, AU - Zeng,Wei, Y1 - 2014/10/07/ PY - 2014/9/25/entrez PY - 2014/9/25/pubmed PY - 2015/5/15/medline SP - 9472 EP - 80 JF - The Journal of organic chemistry JO - J Org Chem VL - 79 IS - 20 N2 - A ruthenium-catalyzed C2-hydroindolation of alkynes has been achieved. This protocol provides a rapid and concise access to kinds of 2-alkenyl-substituted N-(2-pyridyl)indoles in which the pyridyl moiety can be easily removed to afford free (N-H) indoles under mild conditions. Various arenes and alkynes, including electron-deficient and electron-rich internal alkynes and terminal alkynes, allow for this transformation. SN - 1520-6904 UR - https://www.unboundmedicine.com/medline/citation/25251735/Ruthenium_II__catalyzed_direct_addition_of_indole/pyrrole_C2_H_bonds_to_alkynes_ DB - PRIME DP - Unbound Medicine ER -