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Post-infectious bronchiolitis obliterans in children: a review of 42 cases.
BMC Pediatr 2014; 14:238BPed

Abstract

BACKGROUND

This study aimed to describe the clinical characteristics, radiological features and outcomes of 42 children with post-infectious bronchiolitis obliterans (PIBO).

METHODS

Forty-two children diagnosed with PIBO were prospectively studied at the First Hospital of Jilin University in northern China between January, 2008 and January, 2013. Their clinical characteristics, lung high resolution computed tomography (HRCT) findings and pulmonary function tests were reported.

RESULTS

In children with PIBO, adenovirus was the most common etiologic agent (21/42), followed by Mycoplasma pneumoniae (M. pneumoniae). All of the patients presented with repeated wheezing and tachypnea. In addition, 22 patients required intensive management, while six patients required home oxygen therapy. HRCT findings were consistent with the PIBO diagnosis in all of the patients. Pulmonary function testing was useful in evaluating therapeutic responses. Systemic steroids combined with azithromycin were effective for PIBO treatment.

CONCLUSIONS

Severe adenovirus bronchiolitis and M. pneumoniae infections have a higher risk of development for PIBO. HRCT and pulmonary function testing are useful in the diagnosis of PIBO. The degree of airway obstruction did not differ significantly between adenovirus and M. pneumoniae. A combination of steroids and azithromycin offers some benefit in treating these patients.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDepartment of Pediatrics, The First Hospital of Jilin University, Changchun 130021, PR China. hflyn2011@sina.com.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25252824

Citation

Li, Ya-Nan, et al. "Post-infectious Bronchiolitis Obliterans in Children: a Review of 42 Cases." BMC Pediatrics, vol. 14, 2014, p. 238.
Li YN, Liu L, Qiao HM, et al. Post-infectious bronchiolitis obliterans in children: a review of 42 cases. BMC Pediatr. 2014;14:238.
Li, Y. N., Liu, L., Qiao, H. M., Cheng, H., & Cheng, H. J. (2014). Post-infectious bronchiolitis obliterans in children: a review of 42 cases. BMC Pediatrics, 14, p. 238. doi:10.1186/1471-2431-14-238.
Li YN, et al. Post-infectious Bronchiolitis Obliterans in Children: a Review of 42 Cases. BMC Pediatr. 2014 Sep 25;14:238. PubMed PMID: 25252824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-infectious bronchiolitis obliterans in children: a review of 42 cases. AU - Li,Ya-Nan, AU - Liu,Li, AU - Qiao,Hong-Mei, AU - Cheng,Hang, AU - Cheng,Huan-Ji, Y1 - 2014/09/25/ PY - 2014/08/29/received PY - 2014/09/17/accepted PY - 2014/9/26/entrez PY - 2014/9/26/pubmed PY - 2015/4/18/medline SP - 238 EP - 238 JF - BMC pediatrics JO - BMC Pediatr VL - 14 N2 - BACKGROUND: This study aimed to describe the clinical characteristics, radiological features and outcomes of 42 children with post-infectious bronchiolitis obliterans (PIBO). METHODS: Forty-two children diagnosed with PIBO were prospectively studied at the First Hospital of Jilin University in northern China between January, 2008 and January, 2013. Their clinical characteristics, lung high resolution computed tomography (HRCT) findings and pulmonary function tests were reported. RESULTS: In children with PIBO, adenovirus was the most common etiologic agent (21/42), followed by Mycoplasma pneumoniae (M. pneumoniae). All of the patients presented with repeated wheezing and tachypnea. In addition, 22 patients required intensive management, while six patients required home oxygen therapy. HRCT findings were consistent with the PIBO diagnosis in all of the patients. Pulmonary function testing was useful in evaluating therapeutic responses. Systemic steroids combined with azithromycin were effective for PIBO treatment. CONCLUSIONS: Severe adenovirus bronchiolitis and M. pneumoniae infections have a higher risk of development for PIBO. HRCT and pulmonary function testing are useful in the diagnosis of PIBO. The degree of airway obstruction did not differ significantly between adenovirus and M. pneumoniae. A combination of steroids and azithromycin offers some benefit in treating these patients. SN - 1471-2431 UR - https://www.unboundmedicine.com/medline/citation/25252824/Post_infectious_bronchiolitis_obliterans_in_children:_a_review_of_42_cases_ L2 - https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-14-238 DB - PRIME DP - Unbound Medicine ER -