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Antibacterial potential of Manuka honey against three oral bacteria in vitro.

Abstract

Honey is an ancient natural remedy for the treatment of infected wounds. It has regained attention in the medical profession, as it has recently been reported to have a broad-spectrum inhibitory effect against bacteria. Data concerning Manuka honey of New Zealand origin, which is claimed to provide additional non-peroxide antimicrobial activity (so-called standard NPA) against oral pathogens, is still scarce. Therefore, this study aimed to screen for the antibacterial efficacy of different Manuka honey products against S. mutans (OMZ 918), P. gingivalis (OMZ 925) and A. actinomycetemcomitans (OMZ 299). Chlorhexidine and saline served as positive and negative controls, respectively, whereas a Swiss multifloral honey served as control honey without intrinsic non-peroxide activity. Chlorhexidine showed the highest inhibiting potential against all specimens tested. Manuka honey below an NPA value of 15 showed the least bacterial growth-inhibiting potential, even less – although not significantly so – than multifloral Swiss honey. Manuka honey above an NPA value of 15 showed a significantly higher antibacterial effect compared to the other honeys tested. All Manuka honey preparations were more effective in inhibiting the growth of P. gingivalis and A. actinomycetemcomitans, rather than S. mutans. In conclusion, the study showed an NPA dose-dependent antibacterial efficacy of Manuka honey. Further investigations of this natural product are now open for scrutiny.

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  • Authors+Show Affiliations

    ,

    Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Switzerland.

    , , ,

    Source

    Swiss dental journal 124:9 2014 pg 922-4

    MeSH

    Aggregatibacter actinomycetemcomitans
    Anti-Bacterial Agents
    Chlorhexidine
    Honey
    Humans
    In Vitro Techniques
    Leptospermum
    Microbial Sensitivity Tests
    Mouth
    Porphyromonas gingivalis
    Streptococcus mutans

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    25253413

    Citation

    TY - JOUR T1 - Antibacterial potential of Manuka honey against three oral bacteria in vitro. AU - Schmidlin,PatrickSchmidlin R, AU - English,Helen, AU - Duncan,Warwick, AU - Belibasakis,Georgios N, AU - Thurnheer,Thomas, PY - 2014/9/26/entrez PY - 2014/9/26/pubmed PY - 2016/7/28/medline SP - 922 EP - 4 JF - Swiss dental journal JO - Swiss Dent J VL - 124 IS - 9 N2 - Honey is an ancient natural remedy for the treatment of infected wounds. It has regained attention in the medical profession, as it has recently been reported to have a broad-spectrum inhibitory effect against bacteria. Data concerning Manuka honey of New Zealand origin, which is claimed to provide additional non-peroxide antimicrobial activity (so-called standard NPA) against oral pathogens, is still scarce. Therefore, this study aimed to screen for the antibacterial efficacy of different Manuka honey products against S. mutans (OMZ 918), P. gingivalis (OMZ 925) and A. actinomycetemcomitans (OMZ 299). Chlorhexidine and saline served as positive and negative controls, respectively, whereas a Swiss multifloral honey served as control honey without intrinsic non-peroxide activity. Chlorhexidine showed the highest inhibiting potential against all specimens tested. Manuka honey below an NPA value of 15 showed the least bacterial growth-inhibiting potential, even less – although not significantly so – than multifloral Swiss honey. Manuka honey above an NPA value of 15 showed a significantly higher antibacterial effect compared to the other honeys tested. All Manuka honey preparations were more effective in inhibiting the growth of P. gingivalis and A. actinomycetemcomitans, rather than S. mutans. In conclusion, the study showed an NPA dose-dependent antibacterial efficacy of Manuka honey. Further investigations of this natural product are now open for scrutiny. SN - 2296-6498 UR - https://www.unboundmedicine.com/medline/citation/25253413/Antibacterial_potential_of_Manuka_honey_against_three_oral_bacteria_in_vitro_ L2 - http://www.sso.ch/pubmed.cfm?a=sdj-2014-09-01 ER -