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Lower urinary tract symptoms are associated with low levels of serum serotonin, high levels of adiponectin and fasting glucose, and benign prostatic enlargement.
Scand J Urol. 2015 Apr; 49(2):155-61.SJ

Abstract

OBJECTIVE

The aim of this study was to test whether lower urinary tract symptoms (LUTS) and urinary incontinence are associated with the metabolic syndrome (MetS). The association between LUTS and benign prostatic enlargement (BPE) was also investigated.

MATERIAL AND METHODS

A cross-sectional, representative risk factor analysis of LUTS, as measured by the International Prostate Symptom Score (IPSS), and urinary incontinence was conducted. Among 950 representative individuals, aged 69-81 years, the association between clinical, anthropometric, endocrine, metabolic and inflammatory factors on the one hand, as both major and minor aspects of MetS, and LUTS and urinary incontinence, on the other hand, was analysed. The prostate gland volume was measured in a subgroup of 155 randomly selected individuals and the association between LUTS and BPE was estimated.

RESULTS

No significant association was found between LUTS or urinary incontinence and the major aspects of the MetS. However, in a multivariate analysis, serum serotonin showed an independent negative correlation with LUTS and with urinary incontinence while fasting serum glucose and serum adiponectin showed a positive correlation with LUTS. Furthermore, in a subgroup of 155 individuals, the prostate gland volume correlated positively with LUTS.

CONCLUSIONS

The study did not show an association between LUTS or urinary incontinence and the major components of the MetS. However, serum serotonin showed an independent negative correlation with LUTS and with urinary incontinence while fasting serum glucose and serum adiponectin showed a positive correlation with LUTS. The data confirm the general knowledge that BPE may be one of the causative factors of LUTS.

Authors+Show Affiliations

Department of Urology, Institute of Clinical Sciences, Sahlgrenska University Hospital , Gothenburg , Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25253423

Citation

Haghsheno, Mohammad-Ali, et al. "Lower Urinary Tract Symptoms Are Associated With Low Levels of Serum Serotonin, High Levels of Adiponectin and Fasting Glucose, and Benign Prostatic Enlargement." Scandinavian Journal of Urology, vol. 49, no. 2, 2015, pp. 155-61.
Haghsheno MA, Mellström D, Peeker R, et al. Lower urinary tract symptoms are associated with low levels of serum serotonin, high levels of adiponectin and fasting glucose, and benign prostatic enlargement. Scand J Urol. 2015;49(2):155-61.
Haghsheno, M. A., Mellström, D., Peeker, R., Hammarsten, J., Lorentzon, M., Sundh, V., Karlsson, M., Ohlsson, C., & Damber, J. E. (2015). Lower urinary tract symptoms are associated with low levels of serum serotonin, high levels of adiponectin and fasting glucose, and benign prostatic enlargement. Scandinavian Journal of Urology, 49(2), 155-61. https://doi.org/10.3109/21681805.2014.936495
Haghsheno MA, et al. Lower Urinary Tract Symptoms Are Associated With Low Levels of Serum Serotonin, High Levels of Adiponectin and Fasting Glucose, and Benign Prostatic Enlargement. Scand J Urol. 2015;49(2):155-61. PubMed PMID: 25253423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lower urinary tract symptoms are associated with low levels of serum serotonin, high levels of adiponectin and fasting glucose, and benign prostatic enlargement. AU - Haghsheno,Mohammad-Ali, AU - Mellström,Dan, AU - Peeker,Ralph, AU - Hammarsten,Jan, AU - Lorentzon,Mattias, AU - Sundh,Valter, AU - Karlsson,Magnus, AU - Ohlsson,Claes, AU - Damber,Jan-Erik, Y1 - 2014/09/25/ PY - 2014/9/26/entrez PY - 2014/9/26/pubmed PY - 2015/12/15/medline KW - benign prostatic enlargement KW - lower urinary tract symptoms KW - serotonin KW - urinary incontinence SP - 155 EP - 61 JF - Scandinavian journal of urology JO - Scand J Urol VL - 49 IS - 2 N2 - OBJECTIVE: The aim of this study was to test whether lower urinary tract symptoms (LUTS) and urinary incontinence are associated with the metabolic syndrome (MetS). The association between LUTS and benign prostatic enlargement (BPE) was also investigated. MATERIAL AND METHODS: A cross-sectional, representative risk factor analysis of LUTS, as measured by the International Prostate Symptom Score (IPSS), and urinary incontinence was conducted. Among 950 representative individuals, aged 69-81 years, the association between clinical, anthropometric, endocrine, metabolic and inflammatory factors on the one hand, as both major and minor aspects of MetS, and LUTS and urinary incontinence, on the other hand, was analysed. The prostate gland volume was measured in a subgroup of 155 randomly selected individuals and the association between LUTS and BPE was estimated. RESULTS: No significant association was found between LUTS or urinary incontinence and the major aspects of the MetS. However, in a multivariate analysis, serum serotonin showed an independent negative correlation with LUTS and with urinary incontinence while fasting serum glucose and serum adiponectin showed a positive correlation with LUTS. Furthermore, in a subgroup of 155 individuals, the prostate gland volume correlated positively with LUTS. CONCLUSIONS: The study did not show an association between LUTS or urinary incontinence and the major components of the MetS. However, serum serotonin showed an independent negative correlation with LUTS and with urinary incontinence while fasting serum glucose and serum adiponectin showed a positive correlation with LUTS. The data confirm the general knowledge that BPE may be one of the causative factors of LUTS. SN - 2168-1813 UR - https://www.unboundmedicine.com/medline/citation/25253423/Lower_urinary_tract_symptoms_are_associated_with_low_levels_of_serum_serotonin_high_levels_of_adiponectin_and_fasting_glucose_and_benign_prostatic_enlargement_ L2 - https://www.tandfonline.com/doi/full/10.3109/21681805.2014.936495 DB - PRIME DP - Unbound Medicine ER -