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Acute generalized exanthematous pustulosis induced by ceftriaxone use.
Postepy Dermatol Alergol. 2014 Aug; 31(4):269-71.PD

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous rash characterized by the abrupt onset of a generalized pustular rash often accompanied by fever. There is a history of drug use in 90% of the cases. Here we have reported a 15-year-old male patient with sickle cell anemia who developed AGEP after the use of ceftriaxone. Our patient was hospitalized because of vaso-occlusive crisis and on the third day of ceftriaxone treatment, erythematous pustular lesions accompanied with fever were observed on the body and extremities. Resolution of symptoms followed discontinuation of ceftriaxone. Sensitivity to ceftriaxone was shown with a patch test. The AGEP was considered due to clinical and histopathological findings. This is the first pediatric case of AGEP due to ceftriaxone.

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Authors+Show Affiliations

Nacaroglu HT
Department of Pediatric Allergy, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Demet Can Assoc. Prof., MD.
Celegen M
Department of Pediatric Allergy, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Demet Can Assoc. Prof., MD.
Ozek G
Department of Pediatric Hematology, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Canan Vergin Assoc. Prof., MD.
Umac O
Department of Pediatric Hematology, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Canan Vergin Assoc. Prof., MD.
Karkıner CS
Department of Pediatric Allergy, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Demet Can Assoc. Prof., MD.
Yıldırım HT
Department of Pathology, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Gulden Diniz Assoc. Prof., MD.
Can D
Department of Pediatric Allergy, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Demet Can Assoc. Prof., MD.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

25254014

Citation

Nacaroglu, Hikmet Tekin, et al. "Acute Generalized Exanthematous Pustulosis Induced By Ceftriaxone Use." Postepy Dermatologii I Alergologii, vol. 31, no. 4, 2014, pp. 269-71.
Nacaroglu HT, Celegen M, Ozek G, et al. Acute generalized exanthematous pustulosis induced by ceftriaxone use. Postepy Dermatol Alergol. 2014;31(4):269-71.
Nacaroglu, H. T., Celegen, M., Ozek, G., Umac, O., Karkıner, C. S., Yıldırım, H. T., & Can, D. (2014). Acute generalized exanthematous pustulosis induced by ceftriaxone use. Postepy Dermatologii I Alergologii, 31(4), 269-71. https://doi.org/10.5114/pdia.2014.40938
Nacaroglu HT, et al. Acute Generalized Exanthematous Pustulosis Induced By Ceftriaxone Use. Postepy Dermatol Alergol. 2014;31(4):269-71. PubMed PMID: 25254014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute generalized exanthematous pustulosis induced by ceftriaxone use. AU - Nacaroglu,Hikmet Tekin, AU - Celegen,Mehmet, AU - Ozek,Gülcihan, AU - Umac,Ozgur, AU - Karkıner,Canan Sule Unsal, AU - Yıldırım,Hulya Tosun, AU - Can,Demet, Y1 - 2014/09/08/ PY - 2013/08/01/received PY - 2013/09/18/revised PY - 2013/10/20/accepted PY - 2014/9/26/entrez PY - 2014/9/26/pubmed PY - 2014/9/26/medline KW - acute generalized exanthematous pustulosis KW - children KW - drug hypersensitivity SP - 269 EP - 71 JF - Postepy dermatologii i alergologii JO - Postepy Dermatol Alergol VL - 31 IS - 4 N2 - Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous rash characterized by the abrupt onset of a generalized pustular rash often accompanied by fever. There is a history of drug use in 90% of the cases. Here we have reported a 15-year-old male patient with sickle cell anemia who developed AGEP after the use of ceftriaxone. Our patient was hospitalized because of vaso-occlusive crisis and on the third day of ceftriaxone treatment, erythematous pustular lesions accompanied with fever were observed on the body and extremities. Resolution of symptoms followed discontinuation of ceftriaxone. Sensitivity to ceftriaxone was shown with a patch test. The AGEP was considered due to clinical and histopathological findings. This is the first pediatric case of AGEP due to ceftriaxone. SN - 1642-395X UR - https://www.unboundmedicine.com/medline/citation/25254014/Acute_generalized_exanthematous_pustulosis_induced_by_ceftriaxone_use_ DB - PRIME DP - Unbound Medicine ER -