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Dietary fatty acids and risk of coronary heart disease in men: the Kuopio Ischemic Heart Disease Risk Factor Study.

Abstract

OBJECTIVE

The epidemiological evidence of the role of dietary saturated fatty acids (SFA) in the development of coronary heart disease (CHD) is inconsistent. We investigated the associations of dietary fatty acids with the risk of CHD and carotid atherosclerosis in men with high SFA intake and high rates of CHD.

APPROACH AND RESULTS

In total, 1981 men from the population-based Kuopio Ischemic Heart Disease Risk Factor Study (KIHD), aged 42 to 60 years and free of CHD at baseline in 1984 to 1989, were investigated. Food consumption was assessed with 4-day food recording. Multivariate nutrient-density models were used to analyze isocaloric replacement of nutrients. CHD events were ascertained from national registries. Carotid atherosclerosis was assessed by ultrasonography of the common carotid artery intima-media thickness in 1015 men. During the average follow-up of 21.4 years, 183 fatal and 382 nonfatal CHD events occurred. SFA or trans fat intakes were not associated with CHD risk. In contrast, monounsaturated fat intake was associated with increased risk and polyunsaturated fat intake with decreased risk of fatal CHD, whether replacing SFA, trans fat, or carbohydrates. The associations with carotid atherosclerosis were broadly similar, whereas the associations with nonfatal CHD were weaker.

CONCLUSIONS

Our results suggest that SFA intake is not an independent risk factor for CHD, even in a population with higher ranges of SFA intake. In contrast, polyunsaturated fat intake was associated with lower risk of fatal CHD, whether replacing SFA, trans fat, or carbohydrates. Further investigation on the effect of monounsaturated fat on the CHD risk is warranted.

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  • Authors+Show Affiliations

    ,

    From the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. jyrki.virtanen@uef.fi.

    ,

    From the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

    ,

    From the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

    From the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Carotid Artery Diseases
    Carotid Intima-Media Thickness
    Coronary Disease
    Diet Records
    Dietary Fats
    Dietary Fats, Unsaturated
    Eating
    Fatty Acids
    Fatty Acids, Monounsaturated
    Fatty Acids, Unsaturated
    Finland
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Models, Cardiovascular
    Multivariate Analysis
    Risk Factors
    Trans Fatty Acids

    Pub Type(s)

    Journal Article
    Observational Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25256234

    Citation

    Virtanen, Jyrki K., et al. "Dietary Fatty Acids and Risk of Coronary Heart Disease in Men: the Kuopio Ischemic Heart Disease Risk Factor Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 12, 2014, pp. 2679-87.
    Virtanen JK, Mursu J, Tuomainen TP, et al. Dietary fatty acids and risk of coronary heart disease in men: the Kuopio Ischemic Heart Disease Risk Factor Study. Arterioscler Thromb Vasc Biol. 2014;34(12):2679-87.
    Virtanen, J. K., Mursu, J., Tuomainen, T. P., & Voutilainen, S. (2014). Dietary fatty acids and risk of coronary heart disease in men: the Kuopio Ischemic Heart Disease Risk Factor Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(12), pp. 2679-87. doi:10.1161/ATVBAHA.114.304082.
    Virtanen JK, et al. Dietary Fatty Acids and Risk of Coronary Heart Disease in Men: the Kuopio Ischemic Heart Disease Risk Factor Study. Arterioscler Thromb Vasc Biol. 2014;34(12):2679-87. PubMed PMID: 25256234.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fatty acids and risk of coronary heart disease in men: the Kuopio Ischemic Heart Disease Risk Factor Study. AU - Virtanen,Jyrki K, AU - Mursu,Jaakko, AU - Tuomainen,Tomi-Pekka, AU - Voutilainen,Sari, Y1 - 2014/09/25/ PY - 2014/9/27/entrez PY - 2014/9/27/pubmed PY - 2015/4/25/medline KW - atherosclerosis KW - coronary disease KW - fatty acids SP - 2679 EP - 87 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 34 IS - 12 N2 - OBJECTIVE: The epidemiological evidence of the role of dietary saturated fatty acids (SFA) in the development of coronary heart disease (CHD) is inconsistent. We investigated the associations of dietary fatty acids with the risk of CHD and carotid atherosclerosis in men with high SFA intake and high rates of CHD. APPROACH AND RESULTS: In total, 1981 men from the population-based Kuopio Ischemic Heart Disease Risk Factor Study (KIHD), aged 42 to 60 years and free of CHD at baseline in 1984 to 1989, were investigated. Food consumption was assessed with 4-day food recording. Multivariate nutrient-density models were used to analyze isocaloric replacement of nutrients. CHD events were ascertained from national registries. Carotid atherosclerosis was assessed by ultrasonography of the common carotid artery intima-media thickness in 1015 men. During the average follow-up of 21.4 years, 183 fatal and 382 nonfatal CHD events occurred. SFA or trans fat intakes were not associated with CHD risk. In contrast, monounsaturated fat intake was associated with increased risk and polyunsaturated fat intake with decreased risk of fatal CHD, whether replacing SFA, trans fat, or carbohydrates. The associations with carotid atherosclerosis were broadly similar, whereas the associations with nonfatal CHD were weaker. CONCLUSIONS: Our results suggest that SFA intake is not an independent risk factor for CHD, even in a population with higher ranges of SFA intake. In contrast, polyunsaturated fat intake was associated with lower risk of fatal CHD, whether replacing SFA, trans fat, or carbohydrates. Further investigation on the effect of monounsaturated fat on the CHD risk is warranted. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/25256234/Dietary_fatty_acids_and_risk_of_coronary_heart_disease_in_men:_the_Kuopio_Ischemic_Heart_Disease_Risk_Factor_Study_ L2 - http://www.ahajournals.org/doi/full/10.1161/ATVBAHA.114.304082?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -