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Genes and the hypothalamic control of metabolism in humans.

Abstract

Heritability of obesity and body weight variation is high. Molecular genetic studies have led to the identification of mutations in a few genes, with a major effect on obesity (major genes and monogenic forms). Analyses of these genes have helped to unravel important pathways and have created a more profound understanding of body weight regulation. For most individuals, a polygenic basis is relevant for the genetic predisposition to obesity. Small effect sizes are conveyed by the polygenic variants. Hence, only if a number of these variants is harboured, a sizeable phenotypic effect is detectable. Most, if not all, of the genes relevant to weight regulation are expressed in the hypothalamus. This underscores the major role of this region of the brain in body weight regulation.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Essen, Essen, Germany. Electronic address: Anke.hinney@uni-due.de.Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Essen, Essen, Germany. Electronic address: anna-lena.volckmar@uni-due.de.Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Essen, Essen, Germany. Electronic address: jochen.antel@uni-due.de.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25256760

Citation

Hinney, Anke, et al. "Genes and the Hypothalamic Control of Metabolism in Humans." Best Practice & Research. Clinical Endocrinology & Metabolism, vol. 28, no. 5, 2014, pp. 635-47.
Hinney A, Volckmar AL, Antel J. Genes and the hypothalamic control of metabolism in humans. Best Pract Res Clin Endocrinol Metab. 2014;28(5):635-47.
Hinney, A., Volckmar, A. L., & Antel, J. (2014). Genes and the hypothalamic control of metabolism in humans. Best Practice & Research. Clinical Endocrinology & Metabolism, 28(5), pp. 635-47. doi:10.1016/j.beem.2014.04.007.
Hinney A, Volckmar AL, Antel J. Genes and the Hypothalamic Control of Metabolism in Humans. Best Pract Res Clin Endocrinol Metab. 2014;28(5):635-47. PubMed PMID: 25256760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genes and the hypothalamic control of metabolism in humans. AU - Hinney,Anke, AU - Volckmar,Anna-Lena, AU - Antel,Jochen, Y1 - 2014/04/26/ PY - 2014/9/27/entrez PY - 2014/9/27/pubmed PY - 2015/6/11/medline KW - heritability KW - major gene KW - monogenic KW - obesity KW - polygenic variants SP - 635 EP - 47 JF - Best practice & research. Clinical endocrinology & metabolism JO - Best Pract. Res. Clin. Endocrinol. Metab. VL - 28 IS - 5 N2 - Heritability of obesity and body weight variation is high. Molecular genetic studies have led to the identification of mutations in a few genes, with a major effect on obesity (major genes and monogenic forms). Analyses of these genes have helped to unravel important pathways and have created a more profound understanding of body weight regulation. For most individuals, a polygenic basis is relevant for the genetic predisposition to obesity. Small effect sizes are conveyed by the polygenic variants. Hence, only if a number of these variants is harboured, a sizeable phenotypic effect is detectable. Most, if not all, of the genes relevant to weight regulation are expressed in the hypothalamus. This underscores the major role of this region of the brain in body weight regulation. SN - 1878-1594 UR - https://www.unboundmedicine.com/medline/citation/25256760/Genes_and_the_hypothalamic_control_of_metabolism_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-690X(14)00059-1 DB - PRIME DP - Unbound Medicine ER -