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Evaluation of the pro-inflammatory cytokine tumor necrosis factor-α in adolescents with polycystic ovary syndrome.
J Pediatr Adolesc Gynecol. 2014 Dec; 27(6):356-9.JP

Abstract

BACKGROUND

Patients with polycystic ovary syndrome (PCOS) often suffer from comorbidities associated with chronic inflammation characterized by elevations in pro-inflammatory cytokines. There is limited data on markers of chronic inflammation, in particular Tumor Necrosis Factor-alpha (TNF-α), in adolescents with PCOS.

OBJECTIVES

To compare serum levels of TNF-α in overweight or obese adolescents with PCOS and obese controls. In the PCOS group, to correlate serum TNF-α levels with body mass index (BMI) z-score, severity of hyperandrogenism, degree of insulin resistance, and ovarian ultrasonographic characteristics.

METHODS

We performed a cross-sectional retrospective analysis of clinical and biochemical findings in 23 overweight or obese adolescent females with PCOS (mean BMI z-score 2, mean age 15.2 yrs) and 12 obese age- and sex-matched controls (mean BMI z-score 2, mean age 14.1 y). All subjects were post-menarchal. Serum TNF-α levels were compared between groups. In the PCOS group, cytokine levels were correlated with BMI z-score, androgen levels, fasting insulin and glucose levels as well as ovarian ultrasonographic features.

RESULTS

Both groups were comparable in age, BMI z-score, fasting glucose, and fasting insulin. Mean free testosterone was 9.76 ± 5.13 pg/mL in the PCOS group versus 5 ± 2.02 pg/mL in the control group (P = .0092). Serum TNF-α was 7.4 ± 4 pg/mL in the PCOS group versus 4.8 ± 3.16 pg/mL in the control group (P = .0468). There was no significant correlation between serum TNF-α and BMI z-score, free testosterone, fasting insulin, or fasting glucose. No correlation existed between serum TNF-α and ovarian follicle number, distribution, or volume.

CONCLUSIONS

Serum TNF-α is elevated in overweight/obese adolescents with PCOS. Chronic inflammation in adolescents with PCOS render them at a potential increased risk for the development of atherosclerosis, type 2 diabetes, cancer, infertility, and other comorbidities. Every effort should be made to identify adolescents with PCOS early and initiate aggressive therapy to prevent future complications.

Links

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Authors+Show Affiliations

Pawelczak M
Division of Pediatric Endocrinology, Department of Pediatrics, New York University School of Medicine, New York, New York.
Rosenthal J
Division of Pediatric Endocrinology, Department of Pediatrics, New York University School of Medicine, New York, New York.
Milla S
Department of Radiology, New York University School of Medicine, New York, New York.
Liu YH
Department of Pediatrics, New York University School of Medicine, New York, New York.
Shah B
Division of Pediatric Endocrinology, Department of Pediatrics, New York University School of Medicine, New York, New York. Electronic address: bina.shah@nyumc.org.

MeSH

AdolescentBiomarkersBody Mass IndexCross-Sectional StudiesFemaleHumansHyperandrogenismInflammationInsulinInsulin ResistanceObesityOvarian FolliclePolycystic Ovary SyndromeRetrospective StudiesSeverity of Illness IndexTestosteroneTumor Necrosis Factor-alphaUltrasonography

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25256873

Citation

Pawelczak, Melissa, et al. "Evaluation of the Pro-inflammatory Cytokine Tumor Necrosis Factor-α in Adolescents With Polycystic Ovary Syndrome." Journal of Pediatric and Adolescent Gynecology, vol. 27, no. 6, 2014, pp. 356-9.
Pawelczak M, Rosenthal J, Milla S, et al. Evaluation of the pro-inflammatory cytokine tumor necrosis factor-α in adolescents with polycystic ovary syndrome. J Pediatr Adolesc Gynecol. 2014;27(6):356-9.
Pawelczak, M., Rosenthal, J., Milla, S., Liu, Y. H., & Shah, B. (2014). Evaluation of the pro-inflammatory cytokine tumor necrosis factor-α in adolescents with polycystic ovary syndrome. Journal of Pediatric and Adolescent Gynecology, 27(6), 356-9. https://doi.org/10.1016/j.jpag.2014.01.104
Pawelczak M, et al. Evaluation of the Pro-inflammatory Cytokine Tumor Necrosis Factor-α in Adolescents With Polycystic Ovary Syndrome. J Pediatr Adolesc Gynecol. 2014;27(6):356-9. PubMed PMID: 25256873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the pro-inflammatory cytokine tumor necrosis factor-α in adolescents with polycystic ovary syndrome. AU - Pawelczak,Melissa, AU - Rosenthal,Jamie, AU - Milla,Sarah, AU - Liu,Ying-Hua, AU - Shah,Bina, Y1 - 2014/09/23/ PY - 2013/05/01/received PY - 2014/01/23/revised PY - 2014/01/23/accepted PY - 2014/9/27/entrez PY - 2014/9/27/pubmed PY - 2016/2/24/medline KW - Adolescents KW - Polycystic ovary syndrome KW - Tumor necrosis factor-α (TNF-α) SP - 356 EP - 9 JF - Journal of pediatric and adolescent gynecology JO - J Pediatr Adolesc Gynecol VL - 27 IS - 6 N2 - BACKGROUND: Patients with polycystic ovary syndrome (PCOS) often suffer from comorbidities associated with chronic inflammation characterized by elevations in pro-inflammatory cytokines. There is limited data on markers of chronic inflammation, in particular Tumor Necrosis Factor-alpha (TNF-α), in adolescents with PCOS. OBJECTIVES: To compare serum levels of TNF-α in overweight or obese adolescents with PCOS and obese controls. In the PCOS group, to correlate serum TNF-α levels with body mass index (BMI) z-score, severity of hyperandrogenism, degree of insulin resistance, and ovarian ultrasonographic characteristics. METHODS: We performed a cross-sectional retrospective analysis of clinical and biochemical findings in 23 overweight or obese adolescent females with PCOS (mean BMI z-score 2, mean age 15.2 yrs) and 12 obese age- and sex-matched controls (mean BMI z-score 2, mean age 14.1 y). All subjects were post-menarchal. Serum TNF-α levels were compared between groups. In the PCOS group, cytokine levels were correlated with BMI z-score, androgen levels, fasting insulin and glucose levels as well as ovarian ultrasonographic features. RESULTS: Both groups were comparable in age, BMI z-score, fasting glucose, and fasting insulin. Mean free testosterone was 9.76 ± 5.13 pg/mL in the PCOS group versus 5 ± 2.02 pg/mL in the control group (P = .0092). Serum TNF-α was 7.4 ± 4 pg/mL in the PCOS group versus 4.8 ± 3.16 pg/mL in the control group (P = .0468). There was no significant correlation between serum TNF-α and BMI z-score, free testosterone, fasting insulin, or fasting glucose. No correlation existed between serum TNF-α and ovarian follicle number, distribution, or volume. CONCLUSIONS: Serum TNF-α is elevated in overweight/obese adolescents with PCOS. Chronic inflammation in adolescents with PCOS render them at a potential increased risk for the development of atherosclerosis, type 2 diabetes, cancer, infertility, and other comorbidities. Every effort should be made to identify adolescents with PCOS early and initiate aggressive therapy to prevent future complications. SN - 1873-4332 UR - https://www.unboundmedicine.com/medline/citation/25256873/Evaluation_of_the_pro_inflammatory_cytokine_tumor_necrosis_factor_α_in_adolescents_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -