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Serum homocysteine levels, oxidative stress and cardiovascular risk in non-alcoholic steatohepatitis.
Eur J Intern Med. 2014 Oct; 25(8):762-7.EJ

Abstract

INTRODUCTION

Hyperhomocysteinemia is considered an independent risk factor for cardiovascular disease. Oxidative stress is one of the major pathogenic mechanisms in non-alcoholic fatty liver disease and atherosclerosis.

AIM

Our study aimed to evaluate serum homocysteine levels and oxidative stress in patients with biopsy-proven non-alcoholic steatohepatitis and possible association with cardiovascular risk measured by carotid artery intima-media thickness (c-IMT).

PATIENTS AND METHODS

50 patients with non-alcoholic steatohepatitis and 30 healthy controls, age and gender matched, were recruited. Lipid profile, liver biochemical markers, serum homocysteine, vitamins B6 and B12, folic acid, glutathione (reduced and total), erythrocyte superoxide dismutase, whole blood glutathione peroxidase, malondialdehyde and carotid intima-media thickness were assayed.

RESULTS

Patients had an altered lipid profile and liver biochemical markers; carotid intima-media thickness and serum homocysteine levels were significantly higher compared to controls, but there were no differences in folate, B12 and B6 vitamins levels. Patients had significantly lower levels of glutathione peroxidase activity, total and reduced glutathione and higher levels of malondialdehyde, but unchanged superoxide dismutase activity compared to control group. Also, serum homocysteine level showed significant positive correlation with waist circumference, body mass index, free cholesterol, triglycerides, LDL-cholesterol, amino transferases and negative correlation with reduced and total glutathione, superoxide dismutase and γ-GT.

CONCLUSION

Non-alcoholic steatohepatitis is an independent cardiovascular risk factor, associated with elevated homocysteine levels, oxidative stress and c-IMT. c-IMT could be used as an indicator of early atherosclerotic changes initiated by dyslipidemia and oxidative stress, while higher level of homocysteine might be an effect of liver damage.

Authors+Show Affiliations

5th Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.Department of Medical Genetics, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Electronic address: nora_dronca@yahoo.com.Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.5th Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.5th Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.5th Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.Department of Medical Biochemistry, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.5th Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.5th Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25262992

Citation

Leach, Nicoleta V., et al. "Serum Homocysteine Levels, Oxidative Stress and Cardiovascular Risk in Non-alcoholic Steatohepatitis." European Journal of Internal Medicine, vol. 25, no. 8, 2014, pp. 762-7.
Leach NV, Dronca E, Vesa SC, et al. Serum homocysteine levels, oxidative stress and cardiovascular risk in non-alcoholic steatohepatitis. Eur J Intern Med. 2014;25(8):762-7.
Leach, N. V., Dronca, E., Vesa, S. C., Sampelean, D. P., Craciun, E. C., Lupsor, M., Crisan, D., Tarau, R., Rusu, R., Para, I., & Grigorescu, M. (2014). Serum homocysteine levels, oxidative stress and cardiovascular risk in non-alcoholic steatohepatitis. European Journal of Internal Medicine, 25(8), 762-7. https://doi.org/10.1016/j.ejim.2014.09.007
Leach NV, et al. Serum Homocysteine Levels, Oxidative Stress and Cardiovascular Risk in Non-alcoholic Steatohepatitis. Eur J Intern Med. 2014;25(8):762-7. PubMed PMID: 25262992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum homocysteine levels, oxidative stress and cardiovascular risk in non-alcoholic steatohepatitis. AU - Leach,Nicoleta V, AU - Dronca,Eleonora, AU - Vesa,Stefan C, AU - Sampelean,Dorel P, AU - Craciun,Elena C, AU - Lupsor,Monica, AU - Crisan,Dana, AU - Tarau,Roxana, AU - Rusu,Razvan, AU - Para,Ioana, AU - Grigorescu,Mircea, Y1 - 2014/09/26/ PY - 2014/06/06/received PY - 2014/08/09/revised PY - 2014/09/08/accepted PY - 2014/9/30/entrez PY - 2014/9/30/pubmed PY - 2015/7/21/medline KW - Cardiovascular risk KW - Carotid artery intima-media thickness KW - Homocysteine KW - Non-alcoholic steatohepatitis KW - Oxidative stress SP - 762 EP - 7 JF - European journal of internal medicine JO - Eur J Intern Med VL - 25 IS - 8 N2 - INTRODUCTION: Hyperhomocysteinemia is considered an independent risk factor for cardiovascular disease. Oxidative stress is one of the major pathogenic mechanisms in non-alcoholic fatty liver disease and atherosclerosis. AIM: Our study aimed to evaluate serum homocysteine levels and oxidative stress in patients with biopsy-proven non-alcoholic steatohepatitis and possible association with cardiovascular risk measured by carotid artery intima-media thickness (c-IMT). PATIENTS AND METHODS: 50 patients with non-alcoholic steatohepatitis and 30 healthy controls, age and gender matched, were recruited. Lipid profile, liver biochemical markers, serum homocysteine, vitamins B6 and B12, folic acid, glutathione (reduced and total), erythrocyte superoxide dismutase, whole blood glutathione peroxidase, malondialdehyde and carotid intima-media thickness were assayed. RESULTS: Patients had an altered lipid profile and liver biochemical markers; carotid intima-media thickness and serum homocysteine levels were significantly higher compared to controls, but there were no differences in folate, B12 and B6 vitamins levels. Patients had significantly lower levels of glutathione peroxidase activity, total and reduced glutathione and higher levels of malondialdehyde, but unchanged superoxide dismutase activity compared to control group. Also, serum homocysteine level showed significant positive correlation with waist circumference, body mass index, free cholesterol, triglycerides, LDL-cholesterol, amino transferases and negative correlation with reduced and total glutathione, superoxide dismutase and γ-GT. CONCLUSION: Non-alcoholic steatohepatitis is an independent cardiovascular risk factor, associated with elevated homocysteine levels, oxidative stress and c-IMT. c-IMT could be used as an indicator of early atherosclerotic changes initiated by dyslipidemia and oxidative stress, while higher level of homocysteine might be an effect of liver damage. SN - 1879-0828 UR - https://www.unboundmedicine.com/medline/citation/25262992/Serum_homocysteine_levels_oxidative_stress_and_cardiovascular_risk_in_non_alcoholic_steatohepatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0953-6205(14)00252-0 DB - PRIME DP - Unbound Medicine ER -