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Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review.
Climacteric. 2015 Apr; 18(2):260-9.C

Abstract

OBJECTIVE

To perform a meta-analysis examining the efficacy of phytoestrogens for the relief of menopausal symptoms.

METHODS

Medline, Cochrane, EMBASE, and Google Scholar databases were searched until September 30, 2013 using the following key words: vasomotor symptoms, menopausal symptoms, phytoestrogens, isoflavones, coumestrol, soy, red clover. Inclusion criteria were (1) randomized controlled trial (RCT), (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral phytoestrogen. Outcome measures included Kupperman index (KI) changes, daily hot flush frequency, and the likelihood of side-effects.

RESULTS

Of 543 potentially relevant studies identified, 15 RCTs meeting the inclusion criteria were included. The mean age of the subjects ranged from 49 to 58.3 and 48 to 60.1 years, respectively, in the placebo and phytoestrogen groups. The number of participants ranged from 30 to 252, and the intervention periods ranged from 3 to 12 months. Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110). Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005). Meta-analysis of the five studies that reported side-effect data showed no significant difference between the two groups (p = 0.175).

CONCLUSION

Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.

Authors+Show Affiliations

Hsin Sheng Junior College of Medical Care and Management , Taoyuan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

25263312

Citation

Chen, M-N, et al. "Efficacy of Phytoestrogens for Menopausal Symptoms: a Meta-analysis and Systematic Review." Climacteric : the Journal of the International Menopause Society, vol. 18, no. 2, 2015, pp. 260-9.
Chen MN, Lin CC, Liu CF. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric. 2015;18(2):260-9.
Chen, M. N., Lin, C. C., & Liu, C. F. (2015). Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric : the Journal of the International Menopause Society, 18(2), 260-9. https://doi.org/10.3109/13697137.2014.966241
Chen MN, Lin CC, Liu CF. Efficacy of Phytoestrogens for Menopausal Symptoms: a Meta-analysis and Systematic Review. Climacteric. 2015;18(2):260-9. PubMed PMID: 25263312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. AU - Chen,M-N, AU - Lin,C-C, AU - Liu,C-F, Y1 - 2014/12/01/ PY - 2014/9/30/entrez PY - 2014/9/30/pubmed PY - 2015/12/15/medline KW - CLIMACTERIC KW - ESTROGEN KW - HOT FLUSH KW - ISOFLAVONE KW - LIGNAN KW - MENOPAUSE KW - META-ANALYSIS SP - 260 EP - 9 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 18 IS - 2 N2 - OBJECTIVE: To perform a meta-analysis examining the efficacy of phytoestrogens for the relief of menopausal symptoms. METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until September 30, 2013 using the following key words: vasomotor symptoms, menopausal symptoms, phytoestrogens, isoflavones, coumestrol, soy, red clover. Inclusion criteria were (1) randomized controlled trial (RCT), (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral phytoestrogen. Outcome measures included Kupperman index (KI) changes, daily hot flush frequency, and the likelihood of side-effects. RESULTS: Of 543 potentially relevant studies identified, 15 RCTs meeting the inclusion criteria were included. The mean age of the subjects ranged from 49 to 58.3 and 48 to 60.1 years, respectively, in the placebo and phytoestrogen groups. The number of participants ranged from 30 to 252, and the intervention periods ranged from 3 to 12 months. Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110). Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005). Meta-analysis of the five studies that reported side-effect data showed no significant difference between the two groups (p = 0.175). CONCLUSION: Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/25263312/Efficacy_of_phytoestrogens_for_menopausal_symptoms:_a_meta_analysis_and_systematic_review_ L2 - https://www.tandfonline.com/doi/full/10.3109/13697137.2014.966241 DB - PRIME DP - Unbound Medicine ER -