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Association between Helicobacter pylori infection and stroke: a meta-analysis of prospective observational studies.
J Stroke Cerebrovasc Dis. 2014 Oct; 23(9):2233-9.JS

Abstract

BACKGROUND

Some studies have suggested an association between Helicobacter pylori infection and the risk of stroke, but the relationship remains controversial. The aim of this study was to obtain a more comprehensive estimate of H. pylori on the risk of stroke by performing a meta-analysis.

METHODS

A computerized search of PubMed, EMBASE, and the Cochrane library (including CENTRAL) up to February 2014 was performed to identify eligible studies. Prospective studies reported that a multivariate-adjusted estimate for the association between H. pylori and stroke were included. A random-effects model was used to calculate the overall combined risk.

RESULTS

Ten prospective observational studies (6 cohort studies, 4 nested case-control, or case-cohort studies within cohort studies) were included in the meta-analysis. The overall combined odds ratio for H. infection and stroke was .96 (95% confidence interval, .78-1.14). Similar results were yielded in patients with cytotoxin-associated gene-A seropositive strains. The combined estimates were robust across sensitivity analyses and had no observed publication bias.

CONCLUSIONS

In conclusion, our formal meta-analysis indicated no strong association between H. pylori infection and stroke, neither in those with cytotoxin-associated gene-A-positive infection. We believe that future epidemiologic studies of H. pylori and stroke are unlikely to be fruitful.

Authors+Show Affiliations

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.Department of Neurology, The Second Affiliated Hospital of Nanchang University, Guangzhou, People's Republic of China.Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China. Electronic address: lunonghua@163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

25263434

Citation

Yu, Min, et al. "Association Between Helicobacter Pylori Infection and Stroke: a Meta-analysis of Prospective Observational Studies." Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, vol. 23, no. 9, 2014, pp. 2233-9.
Yu M, Zhang Y, Yang Z, et al. Association between Helicobacter pylori infection and stroke: a meta-analysis of prospective observational studies. J Stroke Cerebrovasc Dis. 2014;23(9):2233-9.
Yu, M., Zhang, Y., Yang, Z., Ding, J., Xie, C., & Lu, N. (2014). Association between Helicobacter pylori infection and stroke: a meta-analysis of prospective observational studies. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, 23(9), 2233-9. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.020
Yu M, et al. Association Between Helicobacter Pylori Infection and Stroke: a Meta-analysis of Prospective Observational Studies. J Stroke Cerebrovasc Dis. 2014;23(9):2233-9. PubMed PMID: 25263434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Helicobacter pylori infection and stroke: a meta-analysis of prospective observational studies. AU - Yu,Min, AU - Zhang,Yangbo, AU - Yang,Zhen, AU - Ding,Jiangwu, AU - Xie,Chuan, AU - Lu,Nonghua, PY - 2014/03/12/received PY - 2014/04/03/accepted PY - 2014/9/30/entrez PY - 2014/9/30/pubmed PY - 2015/6/6/medline KW - Helicobacter pylori KW - meta-analysis KW - prospective study KW - stroke SP - 2233 EP - 9 JF - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JO - J Stroke Cerebrovasc Dis VL - 23 IS - 9 N2 - BACKGROUND: Some studies have suggested an association between Helicobacter pylori infection and the risk of stroke, but the relationship remains controversial. The aim of this study was to obtain a more comprehensive estimate of H. pylori on the risk of stroke by performing a meta-analysis. METHODS: A computerized search of PubMed, EMBASE, and the Cochrane library (including CENTRAL) up to February 2014 was performed to identify eligible studies. Prospective studies reported that a multivariate-adjusted estimate for the association between H. pylori and stroke were included. A random-effects model was used to calculate the overall combined risk. RESULTS: Ten prospective observational studies (6 cohort studies, 4 nested case-control, or case-cohort studies within cohort studies) were included in the meta-analysis. The overall combined odds ratio for H. infection and stroke was .96 (95% confidence interval, .78-1.14). Similar results were yielded in patients with cytotoxin-associated gene-A seropositive strains. The combined estimates were robust across sensitivity analyses and had no observed publication bias. CONCLUSIONS: In conclusion, our formal meta-analysis indicated no strong association between H. pylori infection and stroke, neither in those with cytotoxin-associated gene-A-positive infection. We believe that future epidemiologic studies of H. pylori and stroke are unlikely to be fruitful. SN - 1532-8511 UR - https://www.unboundmedicine.com/medline/citation/25263434/Association_between_Helicobacter_pylori_infection_and_stroke:_a_meta_analysis_of_prospective_observational_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1052-3057(14)00206-7 DB - PRIME DP - Unbound Medicine ER -