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Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts.
Chin J Nat Med. 2014 Sep; 12(9):663-71.CJ

Abstract

Paracetamol (PCM) hepatotoxicity is related to reactive oxygen species (ROS) formation and excessive oxidative stress; natural antioxidant compounds have been tested as an alternative therapy. This study evaluated the hepatoprotective activity of an alcoholic extract of Boswellia ovalifoliolata (BO) bark against PCM-induced hepatotoxicity. BO extract also demonstrated antioxidant activity in vitro, as well as scavenger activity against 2, 2-diphenyl-1-picrylhydrazyl. Administration of PCM caused a significant increase in the release of transaminases, alkaline phosphatase, and lactate dehydrogenase in serum. Significant enhancement in hepatic lipid peroxidation and marked depletion in reduced glutathione were observed after parac intoxication with severe alterations in liver histology. BO treatment was able to mitigate hepatic damage induced by acute intoxication of PCM and showed a pronounced protective effect against lipid peroxidation, deviated serum enzymatic variables, and maintained glutathione status toward control. The results clearly demonstrate the hepatoprotective effect of BO against the toxicity induced by PCM.

Authors+Show Affiliations

Department of Pharmacology, A.U. College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh, India 530003.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research (NIPER-Hyderabad), Balanagar, Hyderabad, Andhra Pradesh, India-500037.Department of Pharmacology, A.U. College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh, India 530003.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research (NIPER-Hyderabad), Balanagar, Hyderabad, Andhra Pradesh, India-500037. Electronic address: vgmnaidu@gmail.com.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research (NIPER-Hyderabad), Balanagar, Hyderabad, Andhra Pradesh, India-500037; Pharmacology Division, Indian Institute of Chemical Technology, Habsiguda, Hyderabad, Andhra Pradesh, India-500007. Electronic address: sistla@iict.res.in.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25263977

Citation

Mahesh, Bandari Uma, et al. "Antioxidant and Hepatoprotective Effects of Boswellia Ovalifoliolata Bark Extracts." Chinese Journal of Natural Medicines, vol. 12, no. 9, 2014, pp. 663-71.
Mahesh BU, Shrivastava S, Pragada RR, et al. Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts. Chin J Nat Med. 2014;12(9):663-71.
Mahesh, B. U., Shrivastava, S., Pragada, R. R., Naidu, V. G., & Sistla, R. (2014). Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts. Chinese Journal of Natural Medicines, 12(9), 663-71. https://doi.org/10.1016/S1875-5364(14)60101-1
Mahesh BU, et al. Antioxidant and Hepatoprotective Effects of Boswellia Ovalifoliolata Bark Extracts. Chin J Nat Med. 2014;12(9):663-71. PubMed PMID: 25263977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts. AU - Mahesh,Bandari Uma, AU - Shrivastava,Shweta, AU - Pragada,Rajeswara Rao, AU - Naidu,V G M, AU - Sistla,Ramakrishna, PY - 2013/05/31/received PY - 2014/9/30/entrez PY - 2014/9/30/pubmed PY - 2015/6/3/medline KW - Boswellia ovalifoliolata KW - Hepatoprotection KW - Lipid peroxidation KW - Liver function tests KW - Oxidative stress KW - Paracetamol SP - 663 EP - 71 JF - Chinese journal of natural medicines JO - Chin J Nat Med VL - 12 IS - 9 N2 - Paracetamol (PCM) hepatotoxicity is related to reactive oxygen species (ROS) formation and excessive oxidative stress; natural antioxidant compounds have been tested as an alternative therapy. This study evaluated the hepatoprotective activity of an alcoholic extract of Boswellia ovalifoliolata (BO) bark against PCM-induced hepatotoxicity. BO extract also demonstrated antioxidant activity in vitro, as well as scavenger activity against 2, 2-diphenyl-1-picrylhydrazyl. Administration of PCM caused a significant increase in the release of transaminases, alkaline phosphatase, and lactate dehydrogenase in serum. Significant enhancement in hepatic lipid peroxidation and marked depletion in reduced glutathione were observed after parac intoxication with severe alterations in liver histology. BO treatment was able to mitigate hepatic damage induced by acute intoxication of PCM and showed a pronounced protective effect against lipid peroxidation, deviated serum enzymatic variables, and maintained glutathione status toward control. The results clearly demonstrate the hepatoprotective effect of BO against the toxicity induced by PCM. SN - 1875-5364 UR - https://www.unboundmedicine.com/medline/citation/25263977/Antioxidant_and_hepatoprotective_effects_of_Boswellia_ovalifoliolata_bark_extracts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-5364(14)60101-1 DB - PRIME DP - Unbound Medicine ER -