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Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases.
Clin Immunol. 2014 Dec; 155(2):209-12.CI

Abstract

Coenzyme Q10 (CoQ10) deficiency can manifest diversely, from isolated myopathy to multisystem involvement. Immune dysregulation has not been reported as a feature of the disease. We report a four-year old girl with failure to thrive, recurrent infections, developmental delay with hypotonia, and CoQ10 deficiency with impaired immune function, which improved after CoQ10 and immunoglobulin replacement therapy. Immune dysfunction in CoQ10 deficiency should be considered and treated appropriately.

Authors+Show Affiliations

Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA. Electronic address: sfarough@bwh.harvard.edu.Department of Genetics, Brigham and Women's Hospital, Children's Hospital, Boston, MA, USA.Department of Pediatric Neurology, Massachusetts General Hospital, Boston, MA, USA.Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.Department of Pediatric Neurology, Massachusetts General Hospital, Boston, MA, USA.Pediatric Immunodeficiency Program, Massachusetts General Hospital for Children, Boston, USA. Electronic address: jewalter@mgh.harvard.edu.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25264263

Citation

Farough, S, et al. "Coenzyme Q10 and Immunity: a Case Report and New Implications for Treatment of Recurrent Infections in Metabolic Diseases." Clinical Immunology (Orlando, Fla.), vol. 155, no. 2, 2014, pp. 209-12.
Farough S, Karaa A, Walker MA, et al. Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases. Clin Immunol. 2014;155(2):209-12.
Farough, S., Karaa, A., Walker, M. A., Slate, N., Dasu, T., Verbsky, J., Fusunyan, R., Canapari, C., Kinane, T. B., Van Cleave, J., Sweetser, D. A., Sims, K. B., & Walter, J. E. (2014). Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases. Clinical Immunology (Orlando, Fla.), 155(2), 209-12. https://doi.org/10.1016/j.clim.2014.09.010
Farough S, et al. Coenzyme Q10 and Immunity: a Case Report and New Implications for Treatment of Recurrent Infections in Metabolic Diseases. Clin Immunol. 2014;155(2):209-12. PubMed PMID: 25264263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases. AU - Farough,S, AU - Karaa,A, AU - Walker,M A, AU - Slate,N, AU - Dasu,T, AU - Verbsky,J, AU - Fusunyan,R, AU - Canapari,C, AU - Kinane,T B, AU - Van Cleave,J, AU - Sweetser,D A, AU - Sims,K B, AU - Walter,J E, Y1 - 2014/09/28/ PY - 2014/02/24/received PY - 2014/09/14/revised PY - 2014/09/17/accepted PY - 2014/9/30/entrez PY - 2014/9/30/pubmed PY - 2015/2/20/medline KW - Coenzyme Q(10;) KW - Immune deficiency KW - Mitochondria; KW - Recurrent infections; SP - 209 EP - 12 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 155 IS - 2 N2 - Coenzyme Q10 (CoQ10) deficiency can manifest diversely, from isolated myopathy to multisystem involvement. Immune dysregulation has not been reported as a feature of the disease. We report a four-year old girl with failure to thrive, recurrent infections, developmental delay with hypotonia, and CoQ10 deficiency with impaired immune function, which improved after CoQ10 and immunoglobulin replacement therapy. Immune dysfunction in CoQ10 deficiency should be considered and treated appropriately. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/25264263/Coenzyme_Q10_and_immunity:_A_case_report_and_new_implications_for_treatment_of_recurrent_infections_in_metabolic_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(14)00221-6 DB - PRIME DP - Unbound Medicine ER -