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Hypocholesterolemic effects of Lactobacillus reuteri LR6 in rats fed on high-cholesterol diet.
Int J Food Sci Nutr 2015; 66(1):71-5IJ

Abstract

The bacterium Lactobacillus reuteri LR6, an isolate from breast-fed human infant feces, was tested positive for bile tolerance and bile salt hydrolase activity. It was also evaluated as a potential probiotic with cholesterol-lowering effect in vivo. In this study, 32 male Albino rats were divided into four groups consisting of eight mice per group. For 60 d, group I was fed with normal synthetic diet, group II was fed with cholesterol-enriched diet only, group III was fed with cholesterol-enriched diet supplemented with skimmed milk, and group IV was fed with cholesterol-enriched diet supplemented with L. reuteri LR6-fermented skimmed milk (10(8) cfu/mL). Blood samples were taken to study lipid profile on 0th, 15th, 30th and 60th day. Compared with the control group, the values for total cholesterol (TC), triglyceride (TG), and LDL were reduced significantly in group fed with L. reuteri LR6 but for HDL this difference was not significant. The results indicated that L. reuteri LR6 might be effective as a probiotic with cholesterol-lowering activities.

Authors+Show Affiliations

Microbial Metabolites Laboratory, Dairy Microbiology Division, National Dairy Research Institute , Karnal, Haryana , India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25265203

Citation

Singh, Tejinder Pal, et al. "Hypocholesterolemic Effects of Lactobacillus Reuteri LR6 in Rats Fed On High-cholesterol Diet." International Journal of Food Sciences and Nutrition, vol. 66, no. 1, 2015, pp. 71-5.
Singh TP, Malik RK, Katkamwar SG, et al. Hypocholesterolemic effects of Lactobacillus reuteri LR6 in rats fed on high-cholesterol diet. Int J Food Sci Nutr. 2015;66(1):71-5.
Singh, T. P., Malik, R. K., Katkamwar, S. G., & Kaur, G. (2015). Hypocholesterolemic effects of Lactobacillus reuteri LR6 in rats fed on high-cholesterol diet. International Journal of Food Sciences and Nutrition, 66(1), pp. 71-5. doi:10.3109/09637486.2014.953450.
Singh TP, et al. Hypocholesterolemic Effects of Lactobacillus Reuteri LR6 in Rats Fed On High-cholesterol Diet. Int J Food Sci Nutr. 2015;66(1):71-5. PubMed PMID: 25265203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypocholesterolemic effects of Lactobacillus reuteri LR6 in rats fed on high-cholesterol diet. AU - Singh,Tejinder Pal, AU - Malik,Ravinder Kumar, AU - Katkamwar,Snehal G, AU - Kaur,Gurpreet, Y1 - 2014/09/29/ PY - 2014/9/30/entrez PY - 2014/9/30/pubmed PY - 2015/10/7/medline KW - Bile salt hydrolase KW - Lactobacillus reuteri, probiotic KW - cholesterol-lowering effect KW - hypocholesterolemia SP - 71 EP - 5 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 66 IS - 1 N2 - The bacterium Lactobacillus reuteri LR6, an isolate from breast-fed human infant feces, was tested positive for bile tolerance and bile salt hydrolase activity. It was also evaluated as a potential probiotic with cholesterol-lowering effect in vivo. In this study, 32 male Albino rats were divided into four groups consisting of eight mice per group. For 60 d, group I was fed with normal synthetic diet, group II was fed with cholesterol-enriched diet only, group III was fed with cholesterol-enriched diet supplemented with skimmed milk, and group IV was fed with cholesterol-enriched diet supplemented with L. reuteri LR6-fermented skimmed milk (10(8) cfu/mL). Blood samples were taken to study lipid profile on 0th, 15th, 30th and 60th day. Compared with the control group, the values for total cholesterol (TC), triglyceride (TG), and LDL were reduced significantly in group fed with L. reuteri LR6 but for HDL this difference was not significant. The results indicated that L. reuteri LR6 might be effective as a probiotic with cholesterol-lowering activities. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/25265203/Hypocholesterolemic_effects_of_Lactobacillus_reuteri_LR6_in_rats_fed_on_high_cholesterol_diet_ L2 - http://www.tandfonline.com/doi/full/10.3109/09637486.2014.953450 DB - PRIME DP - Unbound Medicine ER -