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Incidence of fovea plana in normal children.
J AAPOS. 2014 Oct; 18(5):471-5.JA

Abstract

PURPOSE

To characterize the prevalence and features of subclinical foveal hypoplasia detected by optical coherence tomography (OCT) in children.

METHODS

Fast macular OCT scans were performed on normal children with normal vision for the development of a normative OCT-3 database; from this data, eyes with no discernable foveal depression were identified. When possible, the ocular imaging was repeated 3 years later using both OCT-3 and spectral domain OCT (SD-OCT). SD-OCT results were compared to age-matched controls.

RESULTS

Of the 286 normal children (mean age, 8.6 ± 3.1 years) scanned, 9 (mean age, 8 ± 2.9 years; 6 males) were found to have bilateral shallow foveal depression on OCT-3 imaging, including 8 of 154 white children (5.4%) and 1 child of mixed ethnicity (white/black). Children with shallow foveas (n = 9) had larger average foveal thickness (FT) compared to the cohort of controls (n = 277) with a defined fovea (FT = 231.4 ± 8.8 vs 188.8 ± 25.0, resp. [P < 0.0001]). Mean macular volume did not differ from that of controls. SD-OCT performed 3 years later on 5 of the 9 children with shallow foveal depression showed persistence of the inner macular layers over the foveal center, corresponding to grades 1 or 2 of foveal hypoplasia. The FT was increased compared to 5 age-matched controls with a defined fovea (FT = 294.5 ± 5.1 vs 219.75 ± 5.68 μm, resp. [P = 0.029]).

CONCLUSIONS

Up to 3% of children with clinically normal eyes had an anatomically underdeveloped foveal pit bilaterally on OCT.

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Authors+Show Affiliations

Noval S
Duke Eye Center, Durham, North Carolina; Department of Ophthalmology, La Paz University Hospital, IdiPaz, Madrid.
Freedman SF
Duke Eye Center, Durham, North Carolina.
Asrani S
Duke Eye Center, Durham, North Carolina.
El-Dairi MA
Duke Eye Center, Durham, North Carolina. Electronic address: mays.el-dairi@dm.duke.edu.

MeSH

African AmericansChildChild, PreschoolEuropean Continental Ancestry GroupEye Diseases, HereditaryFemaleFollow-Up StudiesFovea CentralisHumansIncidenceMaleNorth CarolinaNystagmus, CongenitalPrevalenceTomography, Optical CoherenceVisual Acuity

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25266830

Citation

Noval, Susana, et al. "Incidence of Fovea Plana in Normal Children." Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus, vol. 18, no. 5, 2014, pp. 471-5.
Noval S, Freedman SF, Asrani S, et al. Incidence of fovea plana in normal children. J AAPOS. 2014;18(5):471-5.
Noval, S., Freedman, S. F., Asrani, S., & El-Dairi, M. A. (2014). Incidence of fovea plana in normal children. Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus, 18(5), 471-5. https://doi.org/10.1016/j.jaapos.2014.07.157
Noval S, et al. Incidence of Fovea Plana in Normal Children. J AAPOS. 2014;18(5):471-5. PubMed PMID: 25266830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of fovea plana in normal children. AU - Noval,Susana, AU - Freedman,Sharon F, AU - Asrani,Sanjay, AU - El-Dairi,Mays A, Y1 - 2014/09/27/ PY - 2013/08/03/received PY - 2014/06/30/revised PY - 2014/07/14/accepted PY - 2014/10/1/entrez PY - 2014/10/1/pubmed PY - 2015/6/26/medline SP - 471 EP - 5 JF - Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus JO - J AAPOS VL - 18 IS - 5 N2 - PURPOSE: To characterize the prevalence and features of subclinical foveal hypoplasia detected by optical coherence tomography (OCT) in children. METHODS: Fast macular OCT scans were performed on normal children with normal vision for the development of a normative OCT-3 database; from this data, eyes with no discernable foveal depression were identified. When possible, the ocular imaging was repeated 3 years later using both OCT-3 and spectral domain OCT (SD-OCT). SD-OCT results were compared to age-matched controls. RESULTS: Of the 286 normal children (mean age, 8.6 ± 3.1 years) scanned, 9 (mean age, 8 ± 2.9 years; 6 males) were found to have bilateral shallow foveal depression on OCT-3 imaging, including 8 of 154 white children (5.4%) and 1 child of mixed ethnicity (white/black). Children with shallow foveas (n = 9) had larger average foveal thickness (FT) compared to the cohort of controls (n = 277) with a defined fovea (FT = 231.4 ± 8.8 vs 188.8 ± 25.0, resp. [P < 0.0001]). Mean macular volume did not differ from that of controls. SD-OCT performed 3 years later on 5 of the 9 children with shallow foveal depression showed persistence of the inner macular layers over the foveal center, corresponding to grades 1 or 2 of foveal hypoplasia. The FT was increased compared to 5 age-matched controls with a defined fovea (FT = 294.5 ± 5.1 vs 219.75 ± 5.68 μm, resp. [P = 0.029]). CONCLUSIONS: Up to 3% of children with clinically normal eyes had an anatomically underdeveloped foveal pit bilaterally on OCT. SN - 1528-3933 UR - https://www.unboundmedicine.com/medline/citation/25266830/Incidence_of_fovea_plana_in_normal_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1091-8531(14)00421-2 DB - PRIME DP - Unbound Medicine ER -