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Comparison of Propofol, Etomidate, and Thiopental in Anesthesia for Electroconvulsive Therapy: A Randomized, Double-blind Clinical Trial.
J ECT. 2015 Jun; 31(2):91-7.JE

Abstract

OBJECTIVES

This study aimed to compare the effects of propofol, thiopental, and etomidate, which are routinely used in anesthesia for electroconvulsive therapy (ECT), on the cardiovascular system, seizure variables, recovery, cognitive functions, and response to treatment.

METHODS

Male patients hospitalized at the Seventh Psychiatry Clinics of the Bakırköy Teaching Hospital for Psychiatry, Neurology, and Neurosurgery who were treated with ECT were investigated prospectively. The effects on cardiovascular system parameters (heart rate, blood pressure, and blood oxygenation), seizure variables (duration and intensity of seizure), and recovery variables were recorded at every session, on prespecified time points, and the findings of the first session were used in this evaluation. In addition, clinical responses to treatment were evaluated with tests of cognitive functions before and after a course of ECT. Adverse effects were recorded.

RESULTS

The sociodemographic characteristics of the 3 treatment groups were similar. There were no significant differences among the groups in terms of effects on cardiovascular system variables, seizure variables, and cognitive functions. The clinical response to ECT was good in all groups, without any significant differences.

CONCLUSIONS

Propofol, etomidate, and thiopental are associated with similar safety and efficacy profiles.

Authors+Show Affiliations

From the *ECT Center, and †Bakırköy Teaching Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul; ‡Faruk Sukan Hospital, Konya and §Department of Psychiatry, School of Medicine, Yildirim Beyazit University, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25268043

Citation

Canbek, Ozge, et al. "Comparison of Propofol, Etomidate, and Thiopental in Anesthesia for Electroconvulsive Therapy: a Randomized, Double-blind Clinical Trial." The Journal of ECT, vol. 31, no. 2, 2015, pp. 91-7.
Canbek O, Ipekcıoglu D, Menges OO, et al. Comparison of Propofol, Etomidate, and Thiopental in Anesthesia for Electroconvulsive Therapy: A Randomized, Double-blind Clinical Trial. J ECT. 2015;31(2):91-7.
Canbek, O., Ipekcıoglu, D., Menges, O. O., Atagun, M. I., Karamustafalıoglu, N., Cetinkaya, O. Z., & Ilnem, M. C. (2015). Comparison of Propofol, Etomidate, and Thiopental in Anesthesia for Electroconvulsive Therapy: A Randomized, Double-blind Clinical Trial. The Journal of ECT, 31(2), 91-7. https://doi.org/10.1097/YCT.0000000000000190
Canbek O, et al. Comparison of Propofol, Etomidate, and Thiopental in Anesthesia for Electroconvulsive Therapy: a Randomized, Double-blind Clinical Trial. J ECT. 2015;31(2):91-7. PubMed PMID: 25268043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Propofol, Etomidate, and Thiopental in Anesthesia for Electroconvulsive Therapy: A Randomized, Double-blind Clinical Trial. AU - Canbek,Ozge, AU - Ipekcıoglu,Derya, AU - Menges,Okan Oktay, AU - Atagun,Murat Ilhan, AU - Karamustafalıoglu,Nesrin, AU - Cetinkaya,Ozlem Zekiye, AU - Ilnem,Mehmet Cem, PY - 2014/10/1/entrez PY - 2014/10/1/pubmed PY - 2016/2/18/medline SP - 91 EP - 7 JF - The journal of ECT JO - J ECT VL - 31 IS - 2 N2 - OBJECTIVES: This study aimed to compare the effects of propofol, thiopental, and etomidate, which are routinely used in anesthesia for electroconvulsive therapy (ECT), on the cardiovascular system, seizure variables, recovery, cognitive functions, and response to treatment. METHODS: Male patients hospitalized at the Seventh Psychiatry Clinics of the Bakırköy Teaching Hospital for Psychiatry, Neurology, and Neurosurgery who were treated with ECT were investigated prospectively. The effects on cardiovascular system parameters (heart rate, blood pressure, and blood oxygenation), seizure variables (duration and intensity of seizure), and recovery variables were recorded at every session, on prespecified time points, and the findings of the first session were used in this evaluation. In addition, clinical responses to treatment were evaluated with tests of cognitive functions before and after a course of ECT. Adverse effects were recorded. RESULTS: The sociodemographic characteristics of the 3 treatment groups were similar. There were no significant differences among the groups in terms of effects on cardiovascular system variables, seizure variables, and cognitive functions. The clinical response to ECT was good in all groups, without any significant differences. CONCLUSIONS: Propofol, etomidate, and thiopental are associated with similar safety and efficacy profiles. SN - 1533-4112 UR - https://www.unboundmedicine.com/medline/citation/25268043/Comparison_of_Propofol_Etomidate_and_Thiopental_in_Anesthesia_for_Electroconvulsive_Therapy:_A_Randomized_Double_blind_Clinical_Trial_ L2 - https://doi.org/10.1097/YCT.0000000000000190 DB - PRIME DP - Unbound Medicine ER -