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Prolactin-lowering effect of luteinizing hormone-releasing hormone agonist administration in prolactinoma patients.
J Clin Endocrinol Metab. 1989 Aug; 69(2):444-7.JC

Abstract

We studied the effect of LHRH agonist administration on serum PRL levels in five women with microprolactinomas and two women and a man with intrasellar macroprolactinomas. Each patient received either D-Trp6-LHRH or buserelin for 90 days. Serum PRL levels decreased significantly in the patients with microprolactinomas by 65%, from 156 +/- 93 (+/- SD) to 54 +/- 49 micrograms/L on day 90 (P = 0.011), but it did not decrease in the macroprolactinoma patients. Mean serum LH and FSH decreased by 43% and 62.5%, respectively, in all eight patients. There was no statistically significant correlation between the serum PRL and LH or FSH levels in the microprolactinoma patients. We conclude that LHRH agonists can counteract the hyperprolactinemia produced by microprolactinomas and that the effect probably is not exerted by an action on the gonadotrophs.

Authors+Show Affiliations

Endocrinology Service, Hospital Universitario San Carlos, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2526819

Citation

Rubio, M A., et al. "Prolactin-lowering Effect of Luteinizing Hormone-releasing Hormone Agonist Administration in Prolactinoma Patients." The Journal of Clinical Endocrinology and Metabolism, vol. 69, no. 2, 1989, pp. 444-7.
Rubio MA, Cabranes JA, Schally AV, et al. Prolactin-lowering effect of luteinizing hormone-releasing hormone agonist administration in prolactinoma patients. J Clin Endocrinol Metab. 1989;69(2):444-7.
Rubio, M. A., Cabranes, J. A., Schally, A. V., & Charro, A. L. (1989). Prolactin-lowering effect of luteinizing hormone-releasing hormone agonist administration in prolactinoma patients. The Journal of Clinical Endocrinology and Metabolism, 69(2), 444-7.
Rubio MA, et al. Prolactin-lowering Effect of Luteinizing Hormone-releasing Hormone Agonist Administration in Prolactinoma Patients. J Clin Endocrinol Metab. 1989;69(2):444-7. PubMed PMID: 2526819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolactin-lowering effect of luteinizing hormone-releasing hormone agonist administration in prolactinoma patients. AU - Rubio,M A, AU - Cabranes,J A, AU - Schally,A V, AU - Charro,A L, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez SP - 444 EP - 7 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 69 IS - 2 N2 - We studied the effect of LHRH agonist administration on serum PRL levels in five women with microprolactinomas and two women and a man with intrasellar macroprolactinomas. Each patient received either D-Trp6-LHRH or buserelin for 90 days. Serum PRL levels decreased significantly in the patients with microprolactinomas by 65%, from 156 +/- 93 (+/- SD) to 54 +/- 49 micrograms/L on day 90 (P = 0.011), but it did not decrease in the macroprolactinoma patients. Mean serum LH and FSH decreased by 43% and 62.5%, respectively, in all eight patients. There was no statistically significant correlation between the serum PRL and LH or FSH levels in the microprolactinoma patients. We conclude that LHRH agonists can counteract the hyperprolactinemia produced by microprolactinomas and that the effect probably is not exerted by an action on the gonadotrophs. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/2526819/Prolactin_lowering_effect_of_luteinizing_hormone_releasing_hormone_agonist_administration_in_prolactinoma_patients_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-69-2-444 DB - PRIME DP - Unbound Medicine ER -