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Long-term physical activity and risk of age-related cataract: a population-based prospective study of male and female cohorts.

Abstract

OBJECTIVE

To examine the association of total and specific types of physical activity, including walking or bicycling, exercising, work or occupational activity, home or housework, and leisure time inactivity with the risk of age-related cataract in women and men.

DESIGN

Population-based prospective cohort study.

PARTICIPANTS

A total of 52 660 participants (23 853 women and 28 807 men) 45 to 83 years of age from the Swedish Mammography Cohort and the Cohort of Swedish Men.

METHODS

Physical activity was assessed using a self-administered questionnaire at baseline. Cataract diagnosis and extraction were identified through linkage to registers.

MAIN OUTCOME MEASURES

Incident age-related cataract diagnosis and cataract extraction.

RESULTS

During a mean 12.1 years of follow-up (between January 1, 1998, and December 31, 2011; 634 631 person-years), 11 580 incident age-related cataract cases were identified. After adjusting for potential confounders, the highest quartile of total physical activity was statistically significantly associated with 13% decreased risk of cataract compared with the lowest (hazard ratio [HR], 0.87; 95% confidence interval [CI], 0.82-0.92). Walking or bicycling (>60 minutes/day vs. hardly ever; HR, 0.88; 95% CI, 0.82-0.95) and work or occupational activity (heavy manual labor vs. mostly sitting; HR, 0.84; 95% CI, 0.78-0.91) also were associated with decreased risk of cataract. Exercise training and home or housework were not associated with cataract risk. Leisure time inactivity was associated with increased risk of cataract (>6 vs. <1 hours/day; HR, 1.27; 95% CI, 1.07-1.50). The HR for high long-term total physical activity compared with low levels both at 30 years of age and at baseline was 0.76 (95% CI, 0.69-0.85).

CONCLUSIONS

Our findings indicate that high total physical activity, especially in the long term, and such specific types of physical activity as walking or bicycling and work or occupational activity, may be associated with decreased risk of age-related cataract. Conversely, high inactivity levels may be associated with increased risk of cataract.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: Jinjin.Zheng@ki.se.

    ,

    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

    ,

    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, Sweden.

    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

    Source

    Ophthalmology 122:2 2015 Feb pg 274-80

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Cataract
    Cohort Studies
    Exercise
    Female
    Humans
    Male
    Middle Aged
    Prospective Studies
    Registries
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25270274

    Citation

    Zheng Selin, Jinjin, et al. "Long-term Physical Activity and Risk of Age-related Cataract: a Population-based Prospective Study of Male and Female cohorts." Ophthalmology, vol. 122, no. 2, 2015, pp. 274-80.
    Zheng Selin J, Orsini N, Ejdervik Lindblad B, et al. Long-term physical activity and risk of age-related cataract: a population-based prospective study of male and female cohorts. Ophthalmology. 2015;122(2):274-80.
    Zheng Selin, J., Orsini, N., Ejdervik Lindblad, B., & Wolk, A. (2015). Long-term physical activity and risk of age-related cataract: a population-based prospective study of male and female cohorts. Ophthalmology, 122(2), pp. 274-80. doi:10.1016/j.ophtha.2014.08.023.
    Zheng Selin J, et al. Long-term Physical Activity and Risk of Age-related Cataract: a Population-based Prospective Study of Male and Female cohorts. Ophthalmology. 2015;122(2):274-80. PubMed PMID: 25270274.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Long-term physical activity and risk of age-related cataract: a population-based prospective study of male and female cohorts. AU - Zheng Selin,Jinjin, AU - Orsini,Nicola, AU - Ejdervik Lindblad,Birgitta, AU - Wolk,Alicja, Y1 - 2014/09/27/ PY - 2014/02/28/received PY - 2014/05/15/revised PY - 2014/08/12/accepted PY - 2014/10/2/entrez PY - 2014/10/2/pubmed PY - 2015/4/15/medline SP - 274 EP - 80 JF - Ophthalmology JO - Ophthalmology VL - 122 IS - 2 N2 - OBJECTIVE: To examine the association of total and specific types of physical activity, including walking or bicycling, exercising, work or occupational activity, home or housework, and leisure time inactivity with the risk of age-related cataract in women and men. DESIGN: Population-based prospective cohort study. PARTICIPANTS: A total of 52 660 participants (23 853 women and 28 807 men) 45 to 83 years of age from the Swedish Mammography Cohort and the Cohort of Swedish Men. METHODS: Physical activity was assessed using a self-administered questionnaire at baseline. Cataract diagnosis and extraction were identified through linkage to registers. MAIN OUTCOME MEASURES: Incident age-related cataract diagnosis and cataract extraction. RESULTS: During a mean 12.1 years of follow-up (between January 1, 1998, and December 31, 2011; 634 631 person-years), 11 580 incident age-related cataract cases were identified. After adjusting for potential confounders, the highest quartile of total physical activity was statistically significantly associated with 13% decreased risk of cataract compared with the lowest (hazard ratio [HR], 0.87; 95% confidence interval [CI], 0.82-0.92). Walking or bicycling (>60 minutes/day vs. hardly ever; HR, 0.88; 95% CI, 0.82-0.95) and work or occupational activity (heavy manual labor vs. mostly sitting; HR, 0.84; 95% CI, 0.78-0.91) also were associated with decreased risk of cataract. Exercise training and home or housework were not associated with cataract risk. Leisure time inactivity was associated with increased risk of cataract (>6 vs. <1 hours/day; HR, 1.27; 95% CI, 1.07-1.50). The HR for high long-term total physical activity compared with low levels both at 30 years of age and at baseline was 0.76 (95% CI, 0.69-0.85). CONCLUSIONS: Our findings indicate that high total physical activity, especially in the long term, and such specific types of physical activity as walking or bicycling and work or occupational activity, may be associated with decreased risk of age-related cataract. Conversely, high inactivity levels may be associated with increased risk of cataract. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/25270274/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(14)00761-1 DB - PRIME DP - Unbound Medicine ER -