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[Erythrocyte filterability and relative viscosity in liver cirrhosis and chronic hepatitis].
Clin Ter 1989; 129(4):243-59CT

Abstract

Fifty patients with liver disease, of whom twenty-four had chronic active hepatitis and twenty-three had liver cirrhosis, were studied and compared with thirty-nine age- and sex-matched controls. Whole blood, plasma and their relative viscosities and the main factors capable of influencing these parameters (Ht, fibrinogen, triglycerides, cholesterol, plasma glucose, total proteins and gamma-globulins) were tested. Whole blood filterability time and velocity of red blood cells (VRBC) were also determined. In ten patients deformability of erythrocytes was determined both in whole blood and in suspensions of RBC in buffer at a Ht of 10%. Whole blood filterability time was significantly increased in all subjects with liver disease. Corrected filterability time was increased only in the cirrhotic group associated with a significant decrease of Ht and fibrinogen and a slight increase in gamma globulins and plasma viscosity. Whole blood viscosity was in the normal range while relative viscosity was decreased in all patients. These findings suggest that both shape alterations of red cells (such as echinocytic shape) and modifications of plasma proteins probably lead to a decrease of red cell filtration in cirrhotic patients.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ita

PubMed ID

2527119

Citation

Mares, M, et al. "[Erythrocyte Filterability and Relative Viscosity in Liver Cirrhosis and Chronic Hepatitis]." La Clinica Terapeutica, vol. 129, no. 4, 1989, pp. 243-59.
Mares M, Visentin I, Radossi P, et al. [Erythrocyte filterability and relative viscosity in liver cirrhosis and chronic hepatitis]. Clin Ter. 1989;129(4):243-59.
Mares, M., Visentin, I., Radossi, P., Boeri, G., & Girolami, A. (1989). [Erythrocyte filterability and relative viscosity in liver cirrhosis and chronic hepatitis]. La Clinica Terapeutica, 129(4), pp. 243-59.
Mares M, et al. [Erythrocyte Filterability and Relative Viscosity in Liver Cirrhosis and Chronic Hepatitis]. Clin Ter. 1989 May 31;129(4):243-59. PubMed PMID: 2527119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Erythrocyte filterability and relative viscosity in liver cirrhosis and chronic hepatitis]. AU - Mares,M, AU - Visentin,I, AU - Radossi,P, AU - Boeri,G, AU - Girolami,A, PY - 1989/5/31/pubmed PY - 1989/5/31/medline PY - 1989/5/31/entrez SP - 243 EP - 59 JF - La Clinica terapeutica JO - Clin Ter VL - 129 IS - 4 N2 - Fifty patients with liver disease, of whom twenty-four had chronic active hepatitis and twenty-three had liver cirrhosis, were studied and compared with thirty-nine age- and sex-matched controls. Whole blood, plasma and their relative viscosities and the main factors capable of influencing these parameters (Ht, fibrinogen, triglycerides, cholesterol, plasma glucose, total proteins and gamma-globulins) were tested. Whole blood filterability time and velocity of red blood cells (VRBC) were also determined. In ten patients deformability of erythrocytes was determined both in whole blood and in suspensions of RBC in buffer at a Ht of 10%. Whole blood filterability time was significantly increased in all subjects with liver disease. Corrected filterability time was increased only in the cirrhotic group associated with a significant decrease of Ht and fibrinogen and a slight increase in gamma globulins and plasma viscosity. Whole blood viscosity was in the normal range while relative viscosity was decreased in all patients. These findings suggest that both shape alterations of red cells (such as echinocytic shape) and modifications of plasma proteins probably lead to a decrease of red cell filtration in cirrhotic patients. SN - 0009-9074 UR - https://www.unboundmedicine.com/medline/citation/2527119/[Erythrocyte_filterability_and_relative_viscosity_in_liver_cirrhosis_and_chronic_hepatitis]_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -